UMET - Liste des publications de Alain HEDOUX
Chapitres d'ouvrage
- A. Hedoux, Raman Spectroscopy in Disordered Molecular Compounds: Application to Pharmaceuticals, in Disordered Pharmaceutical Materials [M. Descamps (eds)], Wiley-VCH pp. 361-392 (2016) [LillOA]
Publications dans des revues internationales
- 2025
- M. Khalaji, L. Paccou, Y. Guinet, A. Hedoux, M. Khalaji, Low-frequency Raman signatures of transient polyamorphic situation in linezolid: A competition between conformational polymorphs, Journal of Chemical Physics 162;7, 074501-9 (2025), [doi: 10.1063/5.0253999, LillOA]
- 2024
- Y. Abdalla, L. McCoubrey, F. Ferraro, L. Sonnleitner, Y. Guinet, F. Siepmann, A. Hedoux, J. Siepmann, A. Basit, M. Orlu, D. Shorthouse, Machine learning of Raman spectra predicts drug release from polysaccharide coatings for targeted colonic delivery, Journal of Controlled Release 374, 103-111 (2024), [doi: 10.1016/j.jconrel.2024.08.010, LillOA]
- M. Khalaji, M.K. Dudek, L. Paccou, F. Danede, Y. Guinet, A. Hedoux, Description of an original molecular ordering process into a disordered crystalline form: the atypical low-temperature transformation of the disordered form III of linezolid, Physical Chemistry Chemical Physics 26;30, 20709-20716 (2024), [doi: 10.1039/D4CP02104E, LillOA]
- 2023
- Y. Guinet, L. Paccou, A. Hedoux, Low-Frequency Raman Spectroscopy: An Exceptional Tool for Exploring Metastability Driven States Induced by Dehydration, Pharmaceutics 15;7, 1955 (2023), [doi: 10.3390/pharmaceutics15071955, LillOA]
- Y. Guinet, L. Paccou, A. Hedoux, Co-Amorphous Versus Deep Eutectic Solvents Formulations for Transdermal Administration, Pharmaceutics 15;10, 1710 (2023), [doi: 10.3390/pharmaceutics15061710, LillOA]
- Y. Guinet, L. Paccou, A. Hedoux, Analysis of Co-Crystallization Mechanism of Theophylline and Citric Acid from Raman Investigations in Pseudo Polymorphic Forms Obtained by Different Synthesis Methods, Molecules 28;4, 1605 (2023), [doi: 10.3390/molecules28041605, LillOA]
- Y. Guinet, L. Paccou, A. Hedoux, Mechanism for Stabilizing an Amorphous Drug Using Amino Acids within Co-Amorphous Blends, Pharmaceutics 15;2, 337 (2023), [doi: 10.3390/pharmaceutics15020337, LillOA]
- B. Moutamenni, N. Tabary, A. Mussi, J. Dhainaut, C. Ciotonea, A. Fadel, L. Paccou, Y. Guinet, A. Hedoux, Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery, Pharmaceutics 15;2, 390 (2023), [doi: 10.3390/pharmaceutics15020390, LillOA]
- 2022
- Y. Guinet, L. Paccou, F. Danede, P. Derollez, A. Hedoux, Identification of incommensurability in L-leucine: can lattice instabilities be considered as general phenomena in hydrophobic amino acids?, Physical Chemistry Chemical Physics 24, 27023-27030 (2022), [doi: 10.1039/d2cp00989g, LillOA]
- K. Wu, S. Feng, A. Hedoux, E. Shalaev, Water structure in glycerol: Spectroscopic and computer simulation investigation of hydrogen bonding and water clustering, Journal of Molecular Liquids 355, 118916 (2022), [doi: 10.1016/j.molliq.2022.118916, LillOA]
- Y. Guinet, L. Paccou, F. Danede, A. Hedoux, Revisiting the phase transition sequence in L-methionine: Description of the disordering mechanism in an essential amino acid, Journal of Chemical Physics 156;3, 034501 (2022), [doi: 10.1063/5.0077743, LillOA]
- B. Moutamenni, N. Tabary, L. Paccou, Y. Guinet, A. Hedoux, MAL: High performance method for loading hydrophobic molecular materials into MCM-41 mesoporous silica – Analysis of confined L-tryptophan by Raman spectroscopy, Journal of Molecular Structure 1254, 132383 (2022), [doi: 10.1016/j.molstruc.2022.132383, LillOA]
- 2021
- T. Starciuc, Y. Guinet, A. Hedoux, E. Shalaev, Water content thresholds in glycerol/water system: Low- and high-wavenumber Raman spectroscopy study, Journal of Molecular Liquids 321, 114678 (2021), [doi: 10.1016/j.molliq.2020.114678, LillOA]
- N. Schaeffer, D.O. Abranches, L.P. Silva, M.A. Martins, P.J. Carvalho, O. Russina, A. Triolo, L. Paccou, Y. Guinet, A. Hedoux, J.A. Coutinho, Non-Ideality in Thymol + Menthol Type V Deep Eutectic Solvents, ACS Sustainable Chemistry & Engineering 9;5, 2203-2211 (2021), [doi: 10.1021/acssuschemeng.0c07874, LillOA]
- Y. Guinet, L. Paccou, F. Danede, A. Hedoux, Confinement of molecular materials using a solid-state loading method: a route for exploring new physical states and their subsequent transformation highlighted by caffeine confined to SBA-15 pores, RSC Advances 11;55, 34564-34571 (2021), [doi: 10.1039/D1RA05757J, LillOA]
- B. Malfait, L. Paccou, N. T. Correia, Y. Guinet, A. Hedoux, Identification of an amorphous-amorphous two-step transformation in indomethacin embedded within mesoporous silica, Microporous and Mesoporous Materials 328, 111502 (2021), [doi: 10.1016/j.micromeso.2021.111502, LillOA]
- 2020
- M. Guerain, Y. Guinet, N. T. Correia, L. Paccou, F. Danede, A. Hedoux, Polymorphism and stability of ibuprofen/nicotinamide cocrystal: The effect of the crystalline synthesis method, International Journal of Pharmaceutics 584, 119454 (2020), [doi: 10.1016/j.ijpharm.2020.119454, LillOA]
- Y. Guinet, L. Paccou, A. Hedoux, A detailed description of the devitrification mechanism of D-mannitol, Physical Chemistry Chemical Physics 22, 5011-5017 (2020), [doi: 10.1039/c9cp05287a, LillOA]
- Y. Guinet, L. Paccou, A. Hedoux, Analysis of xylitol – citric acid system forming deep eutectic solvent: Application for dissolving poorly water-soluble drugs. A combination of calorimetric and Raman investigations, Journal of Molecular Liquids 318, 114317 (2020), [doi: 10.1016/j.molliq.2020.114317, LillOA]
- B. Malfait, N. T. Correia, C. Ciotonea, J. Dhainaut, J.-P. Dacquin, s. royer, N. Tabary, Y. Guinet, A. Hedoux, Manipulating the physical states of confined ibuprofen in SBA-15 based drug delivery systems obtained by solid-state loading: Impact of the loading degree, The Journal of Chemical Physics 153;15, 154506 (2020), [doi: 10.1063/5.0020992, LillOA]
- M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, F. Danede, A. Hedoux, Contribution of low-frequency Raman spectroscopy to determine the solubility curves of drugs in polymers: The case of paracetamol/PVP, European Journal of Pharmaceutics and Biopharmaceutics 154, 222-227 (2020), [doi: 10.1016/j.ejpb.2020.07.012, LillOA]
- A. Dupont, M. Guerain, F. Danede, L. Paccou, Y. Guinet, A. Hedoux, J.-F. willart, Kinetics and mechanism of polymorphic transformation of sorbitol under mechanical milling, International Journal of Pharmaceutics 590, 119902 (2020), [doi: 10.1016/j.ijpharm.2020.119902, LillOA]
- 2019
- T. Starciuc, B. Malfait, F. Danede, L. Paccou, Y. Guinet, N. T. Correia, A. Hedoux, Trehalose or sucrose; which of the two should be used for stabilizing proteins in the solid state? A dilemma investigated by in-situ micro-Raman and dielectric relaxation spectroscopies during and after freeze-drying, Journal of Pharmaceutical Sciences 109;1, 496-504 (2019), [doi: 10.1016/j.xphs.2019.10.055, LillOA]
- M. Latreche, J.-F. willart, M. Guerain, A. Hedoux, F. Danede, Using Milling to Explore Physical States: The Amorphous and Polymorphic Forms of Sulindac, Journal of Pharmaceutical Sciences 108;8, 2635-2642 (2019), [doi: 10.1016/j.xphs.2019.03.017, LillOA]
- M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, A. Hedoux, Polymorphism versus devitrification mechanism: Low-wavenumber Raman investigations in sulindac, International Journal of Pharmaceutics 567, 118476 (2019), [doi: 10.1016/j.ijpharm.2019.118476, LillOA]
- M. Latreche, J.-F. willart, M. Guerain, F. Danede, A. Hedoux, Interest of molecular/crystalline dispersions for the determination of solubility curves of drugs into polymers, International Journal of Pharmaceutics 118626 (2019), [doi: 10.1016/j.ijpharm.2019.118626, LillOA]
- B. Malfait, N. T. Correia, A. Mussi, L. Paccou, Y. Guinet, A. Hedoux, Solid-state loading of organic molecular materials within mesoporous silica matrix: Application to ibuprofen, Microporous and Mesoporous Materials 277, 203-207 (2019), [doi: 10.1016/j.micromeso.2018.10.022, LillOA]
- T. Starciuc, N. Tabary, L. Paccou, L. Duponchel, Y. Guinet, B. Martel, A. Hedoux, A detailed analysis of the influence of β-cyclodextrin derivates on the thermal denaturation of lysozyme, International Journal of Pharmaceutics 554, 1-13 (2019), [doi: 10.1016/j.ijpharm.2018.10.060, LillOA]
- 2018
- S. Nasser, A. Hedoux, A. Giuliani, C. Le Floch-Fouéré, V. Santé-Lhoutellier, I. De Waele, G. Delaplace, Investigation of secondary structure evolution of micellar casein powder upon aging by FTIR and SRCD: consequences on solubility, Journal of the science of food and agriculture 98, 2243-2250 (2018), [doi: 10.1002/jsfa.8711, LillOA]
- Y. Karrout, F. Siepmann, Y. Benzine, L. Paccou, Y. Guinet, A. Hedoux, J. Siepmann, When drugs plasticize film coatings: Unusual formulation effects observed with metoprolol and Eudragit RS, International journal of pharmaceutics 539;1-2, 39-49 (2018), [doi: 10.1016/j.ijpharm.2018.01.014, LillOA]
- S. Nasser, P. Peres De Sa Peixoto Jr, A. Moreau, T. Croguennec, F. Bray, C. Rolando, F. Tessier, A. Hedoux, G. Delaplace, Storage of Micellar Casein Powders with and without Lactose: Consequences on Color, Solubility, and Chemical Modifications, Journal of agricultural and food chemistry 66, 39 (2018), [doi: 10.1021/acs.jafc.7b06147, LillOA]
- 2017
- S. Nasser, A. Moreau, R. Jeantet, A. Hedoux, G. Delaplace, Influence of storage conditions on the functional properties of micellar casein powder, Food and Bioproducts Processing 106, 181-192 (2017), [LillOA]
- T. Starciuc, Y. Guinet, L. Paccou, A. Hedoux, Influence of a Small Amount of Glycerol on the Trehalose Bioprotective Action Analyzed In Situ During Freeze-Drying of Lyzozyme Formulations by Micro-Raman Spectroscopy, Journal of Pharmaceutical Sciences 106, 2988-2997 (2017), [doi: 10.1016/j.xphs.2017.05.040, LillOA]
- S. Nasser, R. Jeantet, P. Peres De Sa Peixoto Jr, G. Ronse, N. Nuns, F. Pourpoint, J. Burgain, C. Gaiani, A. Hedoux, G. Delaplace, Microstructure evolution of micellar casein powder upon ageing: Consequences on rehydration dynamics, Journal of Food Engineering 206, 57-66 (2017), [doi: 10.1016/j.jfoodeng.2017.03.004, LillOA]
- A.V. Frontzek (neé Svanidze), J.P. Embs, L. Paccou, Y. Guinet, A. Hedoux, Low-Frequency Dynamics of BSA Complementarily Studied by Raman and Inelastic Neutron Spectroscopy, The Journal of Physical Chemistry B (2017), [doi: 10.1021/acs.jpcb.7b01395, LillOA]
- Y. Guinet, L. Paccou, F. Danede, P. Derollez, A. Hedoux, Structural description of the marketed form of valsartan: A crystalline mesophase characterized by nanocrystals and conformational disorder, International journal of pharmaceutics (2017), [doi: 10.1016/j.ijpharm.2017.04.067, LillOA]
- A. Hedoux, Y. Guinet, L. Carpentier, L. Paccou, P. Derollez, S.A. Brandán, Structural and vibrational characterization of sugar arabinitol structures employing micro-Raman spectra and DFT calculations, Journal of Molecular Structure 1138, 118-128 (2017), [doi: 10.1016/j.molstruc.2017.03.015, LillOA]
- 2016
- Y. Guinet, L. Carpentier, L. Paccou, P. Derollez, A. Hedoux, Analysis of stochastic crystallization in micron-sized droplets of undercooled liquid l-arabitol, Carbohydrate research 435, 76-82 (2016), [doi: 10.1016/j.carres.2016.09.012, LillOA]
- Y. Guinet, L. Paccou, F. Danede, J.-F. willart, P. Derollez, A. Hedoux, Comparison of amorphous states prepared by melt-quenching and cryomilling polymorphs of carbamazepine, International journal of pharmaceutics 509, 305-313 (2016), [doi: 10.1016/j.ijpharm.2016.05.050, LillOA]
- A. Hedoux, Recent developments in the Raman and infrared investigations of amorphous pharmaceuticals and protein formulations: A review, Advanced Drug Delivery Reviews 100, 133-146 (2016), [doi: 10.1016/j.addr.2015.11.021, LillOA]
- L. Paccou, Y. Guinet, A. Hedoux, A. Frontzek, Study of the phase transition in lysozyme crystals by Raman spectroscopy, Biochimica et Biophysica Acta (BBA) - General Subjects 1860, 412-423 (2016), [doi: 10.1016/j.bbagen.2015.10.020, LillOA]
- J. Junthip, N. Tabary, F. Chai, L. Leclercq, M. Maton, F. Cazaux, C. Neut, L. Paccou, Y. Guinet, J.-N. Staelens, M. Bria, D. Landy, A. Hedoux, N. Blanchemain, B. Martel, Layer-by-layer coating of textile with two oppositely charged cyclodextrin polyelectrolytes for extended drug delivery, Journal of biomedical materials research. Part A 104, 1408-1424 (2016), [doi: 10.1002/jbm.a.35674, LillOA]
- 2015
- A. Hedoux, L. Paccou, P. Derollez, Y. Guinet, Dehydration mechanism of caffeine hydrate and structural description of driven metastable anhydrates analyzed by micro Raman spectroscopy, International journal of pharmaceutics 486, 331-338 (2015), [doi: 10.1016/j.ijpharm.2015.04.001, LillOA]
- 2014
- G. Bellavia, L. Paccou, Y. Guinet, A. Hedoux, How Does Glycerol Enhance the Bioprotective Properties of Trehalose? Insight from Protein-Solvent Dynamics, The Journal of Physical Chemistry B 118, 8928-8934 (2014), [doi: 10.1021/jp500673b, LillOA]
- A. Hedoux, L. Paccou, Y. Guinet, Relationship between β-relaxation and structural stability of lysozyme: Microscopic insight on thermostabilization mechanism by trehalose from Raman spectroscopy experiments, The Journal of Chemical Physics 140, 225102 (2014), [doi: 10.1063/1.4882058, LillOA]
- 2013
- A. Hedoux, L. Paccou, S. Achir, Y. Guinet, Mechanism of protein stabilization by trehalose during freeze-drying analyzed by in situ micro-raman spectroscopy, Journal of Pharmaceutical Sciences 102, 2484-2494 (2013), [doi: 10.1002/jps.23638, LillOA]
- A. Hedoux, Y. Guinet, L. Paccou, P. Derollez, F. Danede, Vibrational and structural properties of amorphous n-butanol: A complementary Raman spectroscopy and X-ray diffraction study, The Journal of Chemical Physics 138, 214506 (2013), [doi: 10.1063/1.4808159, LillOA]
- G. Bellavia, L. Paccou, S. Achir, Y. Guinet, J. Siepmann, A. Hedoux, Analysis of Bulk and Hydration Water During Thermal Lysozyme Denaturation Using Raman Scattering, Food Biophysics 8, 170-176 (2013), [doi: 10.1007/s11483-013-9294-3, LillOA]
- P. Derollez, A. Hedoux, Y. Guinet, F. Danede, L. Paccou, Structure determination of the crystalline phase ofn-butanol by powder X-ray diffraction and study of intermolecular associations by Raman spectroscopy, Acta Crystallographica Section B Structural Science Crystal Engineering and Materials 69, 195-202 (2013), [doi: 10.1107/S0108768113004849, LillOA]
- A. Lerbret, A. Hedoux, B. Annighöfer, M.-C. Bellissent-Funel, Influence of pressure on the low-frequency vibrational modes of lysozyme and water: A complementary inelastic neutron scattering and molecular dynamics simulation study, Proteins. Structure, Function, and Bioinformatics 81, 326-340 (2013), [doi: 10.1002/prot.24189, LillOA]
- A. Hedoux, Y. Guinet, L. Paccou, F. Danede, P. Derollez, Polymorphic transformation of anhydrous caffeine upon grinding and hydrostatic pressurizing analyzed by low-frequency raman spectroscopy, Journal of Pharmaceutical Sciences 102, 162-170 (2013), [doi: 10.1002/jps.23346, LillOA]
- 2012
- P. Blanpain-Avet, A. Hedoux, Y. Guinet, L. Paccou, J. Petit, T. Six, G. Delaplace, Analysis by Raman spectroscopy of the conformational structure of whey proteins constituting fouling deposits during the processing in a heat exchanger, Journal of Food Engineering 110, 86-94 (2012), [doi: 10.1016/j.jfoodeng.2011.12.005, LillOA]
- A. Lerbret, F. Affouard, A. Hedoux, S. Krenzlin, J. Siepmann, M.-C. Bellissent-Funel, M. Descamps, How Strongly Does Trehalose Interact with Lysozyme in the Solid State? Insights from Molecular Dynamics Simulation and Inelastic Neutron Scattering, The Journal of Physical Chemistry B 116, 11103-11116 (2012), [doi: 10.1021/jp3058096, LillOA]
- P. Derollez, Y. Guinet, F. Affouard, F. Danede, L. Carpentier, A. Hedoux, Structure determination ofL-arabinitol by powder X-ray diffraction, Acta Crystallographica Section B Structural Science 68, 407-411 (2012), [doi: 10.1107/S0108768112019994, LillOA]
- A. Hedoux, L. Paccou, S. Achir, Y. Guinet, In situ monitoring of proteins during lyophilization using micro-raman spectroscopy: A description of structural changes induced by dehydration, Journal of Pharmaceutical Sciences 101, 2316-2326 (2012), [doi: 10.1002/jps.23172, LillOA]
- A. Hedoux, J.-A. Seo, Y. Guinet, L. Paccou, Analysis of cold denaturation mechanism of β-lactoglobulin and comparison with thermal denaturation from Raman spectroscopy investigations, Journal of Raman Spectroscopy 43, 16-23 (2012), [doi: 10.1002/jrs.3009, LillOA]
- 2011
- A. Hedoux, Y. Guinet, P. Derollez, E. Dudognon, N. T. Correia, Raman spectroscopy of racemic ibuprofen: Evidence of molecular disorder in phase II, International Journal of Pharmaceutics 421, 45-52 (2011), [doi: 10.1016/j.ijpharm.2011.09.015, LillOA]
- N. Dujardin, E. Dudognon, J.-F. willart, A. Hedoux, Y. Guinet, L. Paccou, M. Descamps, Solid state mutarotation of glucose, J. Phys. Chem. B 115, 1698-1705 (2011), [doi: 10.1021/jp109382j, LillOA]
- A. Hedoux, Y. Guinet, L. Paccou, Analysis of the Mechanism of Lysozyme Pressure Denaturation from Raman Spectroscopy Investigations, and Comparison with Thermal Denaturation, The Journal of Physical Chemistry B 115, 6740-6748 (2011), [doi: 10.1021/jp2014836, LillOA]
- A. Hedoux, A.-A. Decroix, Y. Guinet, L. Paccou, P. Derollez, M. Descamps, Low- and High-Frequency Raman Investigations on Caffeine: Polymorphism, Disorder and Phase Transformation, The Journal of Physical Chemistry B 115, 5746-5753 (2011), [doi: 10.1021/jp112074w, LillOA]
- S. Hubert, S. Briancon, A. Hedoux, Y. Guinet, L. Paccou, H. Fessi, F. Puel, Process induced transformations during tablet manufacturing: Phase transition analysis of caffeine using DSC and low frequency micro-Raman spectroscopy, International journal of pharmaceutics 420, 76-83 (2011), [doi: 10.1016/j.ijpharm.2011.08.028, LillOA]
- A. Hedoux, Y. Guinet, M. Descamps, The contribution of Raman spectroscopy to the analysis of phase transformations in pharmaceutical compounds, International journal of pharmaceutics 417, 17-31 (2011), [doi: 10.1016/j.ijpharm.2011.01.031, LillOA]
- A. Lerbret, F. Affouard, P. Bordat, A. Hedoux, Y. Guinet, M. Descamps, Slowing down of water dynamics in disaccharide aqueous solutions, Journal of Non-Crystalline Solids 357;2, 695-699 (2011), [doi: 10.1016/j.jnoncrysol.2010.05.092, LillOA]
- 2010
- A. Hedoux, S. Krenzlin, L. Paccou, Y. Guinet, M.-P. Leterme-Flament, J. Siepmann, Influence of urea and guanidine hydrochloride on lysozyme stability and thermal denaturation; a correlation between activity, protein dynamics and conformational changes, Physical Chemistry Chemical Physics 40, 13189 (2010), [doi: 10.1039/C0CP00602E, LillOA]
- J.-A. Seo, A. Hedoux, Y. Guinet, L. Paccou, F. Affouard, A. Lerbret, M. Descamps, Thermal Denaturation of Beta-Lactoglobulin and Stabilization Mechanism by Trehalose Analyzed from Raman Spectroscopy Investigations, Journal of Physical Chemistry B 114, 6675 (2010), [doi: 10.1021/jp1006022, LillOA]
- 2006
- J.F. Willart, A. Hedoux, Y. Guinet, F. Danede, L. Paccou, F. Capet, M. Descamps, Metastability release of the form alpha of trehalose by isothermal solid state vitrification, Journal of Physical Chemistry B 110, 11040-11043 (2006), [doi: 10.1021/jp061784r, LillOA]