UMET - Liste des publications de Alain HEDOUX

Chapitres d'ouvrage

1. A. Hedoux, Raman Spectroscopy in Disordered Molecular Compounds: Application to Pharmaceuticals, in Disordered Pharmaceutical Materials [M. Descamps (eds)], Wiley-VCH pp. 361-392 (2016) [LillOA]

Publications dans des revues internationales

• 2025
  66. M. Khalaji, L. Paccou, Y. Guinet, A. Hedoux, M. Khalaji, Low-frequency Raman signatures of transient polyamorphic situation in linezolid: A competition between conformational polymorphs, Journal of Chemical Physics 162;7, 074501-9 (2025), [doi: 10.1063/5.0253999, LillOA]
• 2024
  65. Y. Abdalla, L. McCoubrey, F. Ferraro, L. Sonnleitner, Y. Guinet, F. Siepmann, A. Hedoux, J. Siepmann, A. Basit, M. Orlu, D. Shorthouse, Machine learning of Raman spectra predicts drug release from polysaccharide coatings for targeted colonic delivery, Journal of Controlled Release 374, 103-111 (2024), [doi: 10.1016/j.jconrel.2024.08.010, LillOA]
  64. M. Khalaji, M.K. Dudek, L. Paccou, F. Danede, Y. Guinet, A. Hedoux, Description of an original molecular ordering process into a disordered crystalline form: the atypical low-temperature transformation of the disordered form III of linezolid, Physical Chemistry Chemical Physics 26;30, 20709-20716 (2024), [doi: 10.1039/D4CP02104E, LillOA]
• 2023
  63. Y. Guinet, L. Paccou, A. Hedoux, Low-Frequency Raman Spectroscopy: An Exceptional Tool for Exploring Metastability Driven States Induced by Dehydration, Pharmaceutics 15;7, 1955 (2023), [doi: 10.3390/pharmaceutics15071955, LillOA]
  62. Y. Guinet, L. Paccou, A. Hedoux, Co-Amorphous Versus Deep Eutectic Solvents Formulations for Transdermal Administration, Pharmaceutics 15;10, 1710 (2023), [doi: 10.3390/pharmaceutics15061710, LillOA]
  61. Y. Guinet, L. Paccou, A. Hedoux, Analysis of Co-Crystallization Mechanism of Theophylline and Citric Acid from Raman Investigations in Pseudo Polymorphic Forms Obtained by Different Synthesis Methods, Molecules 28;4, 1605 (2023), [doi: 10.3390/molecules28041605, LillOA]
  60. Y. Guinet, L. Paccou, A. Hedoux, Mechanism for Stabilizing an Amorphous Drug Using Amino Acids within Co-Amorphous Blends, Pharmaceutics 15;2, 337 (2023), [doi: 10.3390/pharmaceutics15020337, LillOA]
  59. B. Moutamenni, N. Tabary, A. Mussi, J. Dhainaut, C. Ciotonea, A. Fadel, L. Paccou, Y. Guinet, A. Hedoux, Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery, Pharmaceutics 15;2, 390 (2023), [doi: 10.3390/pharmaceutics15020390, LillOA]
• 2022
  58. Y. Guinet, L. Paccou, F. Danede, P. Derollez, A. Hedoux, Identification of incommensurability in L-leucine: can lattice instabilities be considered as general phenomena in hydrophobic amino acids?, Physical Chemistry Chemical Physics 24, 27023-27030 (2022), [doi: 10.1039/d2cp00989g, LillOA]
  57. K. Wu, S. Feng, A. Hedoux, E. Shalaev, Water structure in glycerol: Spectroscopic and computer simulation investigation of hydrogen bonding and water clustering, Journal of Molecular Liquids 355, 118916 (2022), [doi: 10.1016/j.molliq.2022.118916, LillOA]
  56. Y. Guinet, L. Paccou, F. Danede, A. Hedoux, Revisiting the phase transition sequence in L-methionine: Description of the disordering mechanism in an essential amino acid, Journal of Chemical Physics 156;3, 034501 (2022), [doi: 10.1063/5.0077743, LillOA]
  55. B. Moutamenni, N. Tabary, L. Paccou, Y. Guinet, A. Hedoux, MAL: High performance method for loading hydrophobic molecular materials into MCM-41 mesoporous silica – Analysis of confined L-tryptophan by Raman spectroscopy, Journal of Molecular Structure 1254, 132383 (2022), [doi: 10.1016/j.molstruc.2022.132383, LillOA]
• 2021
  54. T. Starciuc, Y. Guinet, A. Hedoux, E. Shalaev, Water content thresholds in glycerol/water system: Low- and high-wavenumber Raman spectroscopy study, Journal of Molecular Liquids 321, 114678 (2021), [doi: 10.1016/j.molliq.2020.114678, LillOA]
  53. N. Schaeffer, D.O. Abranches, L.P. Silva, M.A. Martins, P.J. Carvalho, O. Russina, A. Triolo, L. Paccou, Y. Guinet, A. Hedoux, J.A. Coutinho, Non-Ideality in Thymol + Menthol Type V Deep Eutectic Solvents, ACS Sustainable Chemistry & Engineering 9;5, 2203-2211 (2021), [doi: 10.1021/acssuschemeng.0c07874, LillOA]
  52. Y. Guinet, L. Paccou, F. Danede, A. Hedoux, Confinement of molecular materials using a solid-state loading method: a route for exploring new physical states and their subsequent transformation highlighted by caffeine confined to SBA-15 pores, RSC Advances 11;55, 34564-34571 (2021), [doi: 10.1039/D1RA05757J, LillOA]
  51. B. Malfait, L. Paccou, N. T. Correia, Y. Guinet, A. Hedoux, Identification of an amorphous-amorphous two-step transformation in indomethacin embedded within mesoporous silica, Microporous and Mesoporous Materials 328, 111502 (2021), [doi: 10.1016/j.micromeso.2021.111502, LillOA]
• 2020
  50. M. Guerain, Y. Guinet, N. T. Correia, L. Paccou, F. Danede, A. Hedoux, Polymorphism and stability of ibuprofen/nicotinamide cocrystal: The effect of the crystalline synthesis method, International Journal of Pharmaceutics 584, 119454 (2020), [doi: 10.1016/j.ijpharm.2020.119454, LillOA]
  49. Y. Guinet, L. Paccou, A. Hedoux, A detailed description of the devitrification mechanism of D-mannitol, Physical Chemistry Chemical Physics 22, 5011-5017 (2020), [doi: 10.1039/c9cp05287a, LillOA]
  48. Y. Guinet, L. Paccou, A. Hedoux, Analysis of xylitol – citric acid system forming deep eutectic solvent: Application for dissolving poorly water-soluble drugs. A combination of calorimetric and Raman investigations, Journal of Molecular Liquids 318, 114317 (2020), [doi: 10.1016/j.molliq.2020.114317, LillOA]
  47. B. Malfait, N. T. Correia, C. Ciotonea, J. Dhainaut, J.-P. Dacquin, s. royer, N. Tabary, Y. Guinet, A. Hedoux, Manipulating the physical states of confined ibuprofen in SBA-15 based drug delivery systems obtained by solid-state loading: Impact of the loading degree, The Journal of Chemical Physics 153;15, 154506 (2020), [doi: 10.1063/5.0020992, LillOA]
  46. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, F. Danede, A. Hedoux, Contribution of low-frequency Raman spectroscopy to determine the solubility curves of drugs in polymers: The case of paracetamol/PVP, European Journal of Pharmaceutics and Biopharmaceutics 154, 222-227 (2020), [doi: 10.1016/j.ejpb.2020.07.012, LillOA]
  45. A. Dupont, M. Guerain, F. Danede, L. Paccou, Y. Guinet, A. Hedoux, J.-F. willart, Kinetics and mechanism of polymorphic transformation of sorbitol under mechanical milling, International Journal of Pharmaceutics 590, 119902 (2020), [doi: 10.1016/j.ijpharm.2020.119902, LillOA]
• 2019
  44. T. Starciuc, B. Malfait, F. Danede, L. Paccou, Y. Guinet, N. T. Correia, A. Hedoux, Trehalose or sucrose; which of the two should be used for stabilizing proteins in the solid state? A dilemma investigated by in-situ micro-Raman and dielectric relaxation spectroscopies during and after freeze-drying, Journal of Pharmaceutical Sciences 109;1, 496-504 (2019), [doi: 10.1016/j.xphs.2019.10.055, LillOA]
  43. M. Latreche, J.-F. willart, M. Guerain, A. Hedoux, F. Danede, Using Milling to Explore Physical States: The Amorphous and Polymorphic Forms of Sulindac, Journal of Pharmaceutical Sciences 108;8, 2635-2642 (2019), [doi: 10.1016/j.xphs.2019.03.017, LillOA]
  42. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, A. Hedoux, Polymorphism versus devitrification mechanism: Low-wavenumber Raman investigations in sulindac, International Journal of Pharmaceutics 567, 118476 (2019), [doi: 10.1016/j.ijpharm.2019.118476, LillOA]
  41. M. Latreche, J.-F. willart, M. Guerain, F. Danede, A. Hedoux, Interest of molecular/crystalline dispersions for the determination of solubility curves of drugs into polymers, International Journal of Pharmaceutics 118626 (2019), [doi: 10.1016/j.ijpharm.2019.118626, LillOA]
  40. B. Malfait, N. T. Correia, A. Mussi, L. Paccou, Y. Guinet, A. Hedoux, Solid-state loading of organic molecular materials within mesoporous silica matrix: Application to ibuprofen, Microporous and Mesoporous Materials 277, 203-207 (2019), [doi: 10.1016/j.micromeso.2018.10.022, LillOA]
  39. T. Starciuc, N. Tabary, L. Paccou, L. Duponchel, Y. Guinet, B. Martel, A. Hedoux, A detailed analysis of the influence of β-cyclodextrin derivates on the thermal denaturation of lysozyme, International Journal of Pharmaceutics 554, 1-13 (2019), [doi: 10.1016/j.ijpharm.2018.10.060, LillOA]
• 2018
  38. S. Nasser, A. Hedoux, A. Giuliani, C. Le Floch-Fouéré, V. Santé-Lhoutellier, I. De Waele, G. Delaplace, Investigation of secondary structure evolution of micellar casein powder upon aging by FTIR and SRCD: consequences on solubility, Journal of the science of food and agriculture 98, 2243-2250 (2018), [doi: 10.1002/jsfa.8711, LillOA]
  37. Y. Karrout, F. Siepmann, Y. Benzine, L. Paccou, Y. Guinet, A. Hedoux, J. Siepmann, When drugs plasticize film coatings: Unusual formulation effects observed with metoprolol and Eudragit RS, International journal of pharmaceutics 539;1-2, 39-49 (2018), [doi: 10.1016/j.ijpharm.2018.01.014, LillOA]
  36. S. Nasser, P. Peres De Sa Peixoto Jr, A. Moreau, T. Croguennec, F. Bray, C. Rolando, F. Tessier, A. Hedoux, G. Delaplace, Storage of Micellar Casein Powders with and without Lactose: Consequences on Color, Solubility, and Chemical Modifications, Journal of agricultural and food chemistry 66, 39 (2018), [doi: 10.1021/acs.jafc.7b06147, LillOA]
• 2017
  35. S. Nasser, A. Moreau, R. Jeantet, A. Hedoux, G. Delaplace, Influence of storage conditions on the functional properties of micellar casein powder, Food and Bioproducts Processing 106, 181-192 (2017), [LillOA]
  34. T. Starciuc, Y. Guinet, L. Paccou, A. Hedoux, Influence of a Small Amount of Glycerol on the Trehalose Bioprotective Action Analyzed In Situ During Freeze-Drying of Lyzozyme Formulations by Micro-Raman Spectroscopy, Journal of Pharmaceutical Sciences 106, 2988-2997 (2017), [doi: 10.1016/j.xphs.2017.05.040, LillOA]
  33. S. Nasser, R. Jeantet, P. Peres De Sa Peixoto Jr, G. Ronse, N. Nuns, F. Pourpoint, J. Burgain, C. Gaiani, A. Hedoux, G. Delaplace, Microstructure evolution of micellar casein powder upon ageing: Consequences on rehydration dynamics, Journal of Food Engineering 206, 57-66 (2017), [doi: 10.1016/j.jfoodeng.2017.03.004, LillOA]
  32. A.V. Frontzek (neé Svanidze), J.P. Embs, L. Paccou, Y. Guinet, A. Hedoux, Low-Frequency Dynamics of BSA Complementarily Studied by Raman and Inelastic Neutron Spectroscopy, The Journal of Physical Chemistry B (2017), [doi: 10.1021/acs.jpcb.7b01395, LillOA]
  31. Y. Guinet, L. Paccou, F. Danede, P. Derollez, A. Hedoux, Structural description of the marketed form of valsartan: A crystalline mesophase characterized by nanocrystals and conformational disorder, International journal of pharmaceutics (2017), [doi: 10.1016/j.ijpharm.2017.04.067, LillOA]
  30. A. Hedoux, Y. Guinet, L. Carpentier, L. Paccou, P. Derollez, S.A. Brandán, Structural and vibrational characterization of sugar arabinitol structures employing micro-Raman spectra and DFT calculations, Journal of Molecular Structure 1138, 118-128 (2017), [doi: 10.1016/j.molstruc.2017.03.015, LillOA]
• 2016
  29. Y. Guinet, L. Carpentier, L. Paccou, P. Derollez, A. Hedoux, Analysis of stochastic crystallization in micron-sized droplets of undercooled liquid l-arabitol, Carbohydrate research 435, 76-82 (2016), [doi: 10.1016/j.carres.2016.09.012, LillOA]
  28. Y. Guinet, L. Paccou, F. Danede, J.-F. willart, P. Derollez, A. Hedoux, Comparison of amorphous states prepared by melt-quenching and cryomilling polymorphs of carbamazepine, International journal of pharmaceutics 509, 305-313 (2016), [doi: 10.1016/j.ijpharm.2016.05.050, LillOA]
  27. A. Hedoux, Recent developments in the Raman and infrared investigations of amorphous pharmaceuticals and protein formulations: A review, Advanced Drug Delivery Reviews 100, 133-146 (2016), [doi: 10.1016/j.addr.2015.11.021, LillOA]
  26. L. Paccou, Y. Guinet, A. Hedoux, A. Frontzek, Study of the phase transition in lysozyme crystals by Raman spectroscopy, Biochimica et Biophysica Acta (BBA) - General Subjects 1860, 412-423 (2016), [doi: 10.1016/j.bbagen.2015.10.020, LillOA]
  25. J. Junthip, N. Tabary, F. Chai, L. Leclercq, M. Maton, F. Cazaux, C. Neut, L. Paccou, Y. Guinet, J.-N. Staelens, M. Bria, D. Landy, A. Hedoux, N. Blanchemain, B. Martel, Layer-by-layer coating of textile with two oppositely charged cyclodextrin polyelectrolytes for extended drug delivery, Journal of biomedical materials research. Part A 104, 1408-1424 (2016), [doi: 10.1002/jbm.a.35674, LillOA]
• 2015
  24. A. Hedoux, L. Paccou, P. Derollez, Y. Guinet, Dehydration mechanism of caffeine hydrate and structural description of driven metastable anhydrates analyzed by micro Raman spectroscopy, International journal of pharmaceutics 486, 331-338 (2015), [doi: 10.1016/j.ijpharm.2015.04.001, LillOA]
• 2014
  23. G. Bellavia, L. Paccou, Y. Guinet, A. Hedoux, How Does Glycerol Enhance the Bioprotective Properties of Trehalose? Insight from Protein-Solvent Dynamics, The Journal of Physical Chemistry B 118, 8928-8934 (2014), [doi: 10.1021/jp500673b, LillOA]
  22. A. Hedoux, L. Paccou, Y. Guinet, Relationship between β-relaxation and structural stability of lysozyme: Microscopic insight on thermostabilization mechanism by trehalose from Raman spectroscopy experiments, The Journal of Chemical Physics 140, 225102 (2014), [doi: 10.1063/1.4882058, LillOA]
• 2013
  21. A. Hedoux, L. Paccou, S. Achir, Y. Guinet, Mechanism of protein stabilization by trehalose during freeze-drying analyzed by in situ micro-raman spectroscopy, Journal of Pharmaceutical Sciences 102, 2484-2494 (2013), [doi: 10.1002/jps.23638, LillOA]
  20. A. Hedoux, Y. Guinet, L. Paccou, P. Derollez, F. Danede, Vibrational and structural properties of amorphous n-butanol: A complementary Raman spectroscopy and X-ray diffraction study, The Journal of Chemical Physics 138, 214506 (2013), [doi: 10.1063/1.4808159, LillOA]
  19. G. Bellavia, L. Paccou, S. Achir, Y. Guinet, J. Siepmann, A. Hedoux, Analysis of Bulk and Hydration Water During Thermal Lysozyme Denaturation Using Raman Scattering, Food Biophysics 8, 170-176 (2013), [doi: 10.1007/s11483-013-9294-3, LillOA]
  18. P. Derollez, A. Hedoux, Y. Guinet, F. Danede, L. Paccou, Structure determination of the crystalline phase ofn-butanol by powder X-ray diffraction and study of intermolecular associations by Raman spectroscopy, Acta Crystallographica Section B Structural Science Crystal Engineering and Materials 69, 195-202 (2013), [doi: 10.1107/S0108768113004849, LillOA]
  17. A. Lerbret, A. Hedoux, B. Annighöfer, M.-C. Bellissent-Funel, Influence of pressure on the low-frequency vibrational modes of lysozyme and water: A complementary inelastic neutron scattering and molecular dynamics simulation study, Proteins. Structure, Function, and Bioinformatics 81, 326-340 (2013), [doi: 10.1002/prot.24189, LillOA]
  16. A. Hedoux, Y. Guinet, L. Paccou, F. Danede, P. Derollez, Polymorphic transformation of anhydrous caffeine upon grinding and hydrostatic pressurizing analyzed by low-frequency raman spectroscopy, Journal of Pharmaceutical Sciences 102, 162-170 (2013), [doi: 10.1002/jps.23346, LillOA]
• 2012
  15. P. Blanpain-Avet, A. Hedoux, Y. Guinet, L. Paccou, J. Petit, T. Six, G. Delaplace, Analysis by Raman spectroscopy of the conformational structure of whey proteins constituting fouling deposits during the processing in a heat exchanger, Journal of Food Engineering 110, 86-94 (2012), [doi: 10.1016/j.jfoodeng.2011.12.005, LillOA]
  14. A. Lerbret, F. Affouard, A. Hedoux, S. Krenzlin, J. Siepmann, M.-C. Bellissent-Funel, M. Descamps, How Strongly Does Trehalose Interact with Lysozyme in the Solid State? Insights from Molecular Dynamics Simulation and Inelastic Neutron Scattering, The Journal of Physical Chemistry B 116, 11103-11116 (2012), [doi: 10.1021/jp3058096, LillOA]
  13. P. Derollez, Y. Guinet, F. Affouard, F. Danede, L. Carpentier, A. Hedoux, Structure determination ofL-arabinitol by powder X-ray diffraction, Acta Crystallographica Section B Structural Science 68, 407-411 (2012), [doi: 10.1107/S0108768112019994, LillOA]
  12. A. Hedoux, L. Paccou, S. Achir, Y. Guinet, In situ monitoring of proteins during lyophilization using micro-raman spectroscopy: A description of structural changes induced by dehydration, Journal of Pharmaceutical Sciences 101, 2316-2326 (2012), [doi: 10.1002/jps.23172, LillOA]
  11. A. Hedoux, J.-A. Seo, Y. Guinet, L. Paccou, Analysis of cold denaturation mechanism of β-lactoglobulin and comparison with thermal denaturation from Raman spectroscopy investigations, Journal of Raman Spectroscopy 43, 16-23 (2012), [doi: 10.1002/jrs.3009, LillOA]
• 2011
  10. A. Hedoux, Y. Guinet, P. Derollez, E. Dudognon, N. T. Correia, Raman spectroscopy of racemic ibuprofen: Evidence of molecular disorder in phase II, International Journal of Pharmaceutics 421, 45-52 (2011), [doi: 10.1016/j.ijpharm.2011.09.015, LillOA]
  9. N. Dujardin, E. Dudognon, J.-F. willart, A. Hedoux, Y. Guinet, L. Paccou, M. Descamps, Solid state mutarotation of glucose, J. Phys. Chem. B 115, 1698-1705 (2011), [doi: 10.1021/jp109382j, LillOA]
  8. A. Hedoux, Y. Guinet, L. Paccou, Analysis of the Mechanism of Lysozyme Pressure Denaturation from Raman Spectroscopy Investigations, and Comparison with Thermal Denaturation, The Journal of Physical Chemistry B 115, 6740-6748 (2011), [doi: 10.1021/jp2014836, LillOA]
  7. S. Hubert, S. Briancon, A. Hedoux, Y. Guinet, L. Paccou, H. Fessi, F. Puel, Process induced transformations during tablet manufacturing: Phase transition analysis of caffeine using DSC and low frequency micro-Raman spectroscopy, International journal of pharmaceutics 420, 76-83 (2011), [doi: 10.1016/j.ijpharm.2011.08.028, LillOA]
  6. A. Hedoux, A.-A. Decroix, Y. Guinet, L. Paccou, P. Derollez, M. Descamps, Low- and High-Frequency Raman Investigations on Caffeine: Polymorphism, Disorder and Phase Transformation, The Journal of Physical Chemistry B 115, 5746-5753 (2011), [doi: 10.1021/jp112074w, LillOA]
  5. A. Hedoux, Y. Guinet, M. Descamps, The contribution of Raman spectroscopy to the analysis of phase transformations in pharmaceutical compounds, International journal of pharmaceutics 417, 17-31 (2011), [doi: 10.1016/j.ijpharm.2011.01.031, LillOA]
  4. A. Lerbret, F. Affouard, P. Bordat, A. Hedoux, Y. Guinet, M. Descamps, Slowing down of water dynamics in disaccharide aqueous solutions, Journal of Non-Crystalline Solids 357;2, 695-699 (2011), [doi: 10.1016/j.jnoncrysol.2010.05.092, LillOA]
• 2010
  3. A. Hedoux, S. Krenzlin, L. Paccou, Y. Guinet, M.-P. Leterme-Flament, J. Siepmann, Influence of urea and guanidine hydrochloride on lysozyme stability and thermal denaturation; a correlation between activity, protein dynamics and conformational changes, Physical Chemistry Chemical Physics 40, 13189 (2010), [doi: 10.1039/C0CP00602E, LillOA]
  2. J.-A. Seo, A. Hedoux, Y. Guinet, L. Paccou, F. Affouard, A. Lerbret, M. Descamps, Thermal Denaturation of Beta-Lactoglobulin and Stabilization Mechanism by Trehalose Analyzed from Raman Spectroscopy Investigations, Journal of Physical Chemistry B 114, 6675 (2010), [doi: 10.1021/jp1006022, LillOA]
• 2006
  1. J.F. Willart, A. Hedoux, Y. Guinet, F. Danede, L. Paccou, F. Capet, M. Descamps, Metastability release of the form alpha of trehalose by isothermal solid state vitrification, Journal of Physical Chemistry B 110, 11040-11043 (2006), [doi: 10.1021/jp061784r, LillOA]