Mathieu GUERAIN

Maître de Conférences Université de Lille, FST-Dép Physique

Bat P6 bureau 213
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: 03 20 43 69 90
Fax: +33 (0)3 20 43 40 84
Courriel : Envoyer un mel à Mathieu GUERAIN
Identifiant ORCID : 0000-0002-7254-9014

Equipe: Matériaux moléculaires et thérapeutiques

Recherche

Résolution Structurale, Transformation polymorphiques sous broyage, Grands Instruments

Enseignement

Matériaux

Energie et Environnement

Capteurs et Chaines de Mesures

Thèses soutenues

• Anthony DUPONT, Investigations cinétiques des transformations de phase des matériaux pharmaceutiques sous broyage. Thèse soutenue en 2022. Co-direction: Jean-François WILLART.

Derniers dépôts dans dans LillOA (Lille Open Archive)

Publications

14. M. Guerain, N. T. Correia, L.-V. Roca Paixao, H. Chevreau, F. Affouard, Using synchrotron high-resolution powder X-ray diffraction for the structure determination of a new cocrystal formed by two active principle ingredients, Acta Crystallographica Section C Structural Chemistry 80;2, 37-42 (2024), [doi: 10.1107/s2053229624000639, LillOA]
13. L.-V. Roca Paixao, N. T. Correia, F. Danede, M. Guerain, F. Affouard, Carbamazepine/Tartaric Acid Cocrystalline Forms: When Stoichiometry and Synthesis Method Matter, Crystal Growth & Design 23;3, 1355-1369 (2023), [doi: 10.1021/acs.cgd.2c00859, LillOA]
12. M. Guerain, P. Palmas, A. Lecardeur, Structural evolution of HMX during processing operations, Journal of Energetic Materials 1-13 (2023), [doi: 10.1080/07370652.2023.2267558, LillOA]
11. A. Dupont, M. Guerain, F. Danede, J.-F. willart, Evidence of transient amorphization during the polymorphic transformation of sorbitol induced by milling, International Journal of Pharmaceutics 121929 (2022), [doi: 10.1016/j.ijpharm.2022.121929, LillOA]
10. E. Dudognon, F. Danede, M. Guerain, Milling-induced Phase Transformations, Underlying Mechanisms and Resulting Physical States in an Enantiotropic System: the Case of Bezafibrate, Crystal Growth & Design 22;1, 363-378 (2022), [doi: 10.1021/acs.cgd.1c00997, LillOA]
9. M. Guerain, F. Affouard, C. Henaff, C. Dejoie, F. Danede, J. Siepmann, F. Siepmann, J.-F. Willart, Structure determination of riboflavin by synchrotron high-resolution powder X-ray diffraction, Acta Crystallographica Section C Structural Chemistry 77;12, 800-806 (2021), [doi: 10.1107/s2053229621012171, LillOA]
8. M. Guerain, Y. Guinet, N. T. Correia, L. Paccou, F. Danede, A. Hedoux, Polymorphism and stability of ibuprofen/nicotinamide cocrystal: The effect of the crystalline synthesis method, International Journal of Pharmaceutics 584, 119454 (2020), [doi: 10.1016/j.ijpharm.2020.119454, LillOA]
7. M. Guerain, A Review on High Pressure Experiments for Study of Crystallographic Behavior and Polymorphism of Pharmaceutical Materials, Journal of Pharmaceutical Sciences 109;9, 2640-2653 (2020), [doi: 10.1016/j.xphs.2020.05.021, LillOA]
6. A. Dupont, M. Guerain, F. Danede, L. Paccou, Y. Guinet, A. Hedoux, J.-F. willart, Kinetics and mechanism of polymorphic transformation of sorbitol under mechanical milling, International Journal of Pharmaceutics 590, 119902 (2020), [doi: 10.1016/j.ijpharm.2020.119902, LillOA]
5. M. Guerain, P. Derollez, L.-V. Roca Paixao, C. Dejoie, N. T. Correia, F. Affouard, Structure determination of Carbamazepine/DL-TA co-crystal by synchrotron powder X-ray diffraction, Acta Crystallographica Section C Structural Chemistry 76, (2020), [LillOA]
4. F. Ngono, G.J. Cuello, M. Jimenez-Ruiz, J.-F. Willart, M. Guerain, A.R. Wildes, A. Stunault, M. Hamoudi, F. Affouard, Morphological and structural properties of amorphous lactulose studied by scanning electron microscopy, polarised neutron scattering, and molecular dynamics simulations, Molecular Pharmaceutics 17, 10-20 (2020), [doi: 10.1021/acs.molpharmaceut.9b00767, LillOA]
3. M. Latreche, J.-F. willart, M. Guerain, A. Hedoux, F. Danede, Using Milling to Explore Physical States: The Amorphous and Polymorphic Forms of Sulindac, Journal of Pharmaceutical Sciences 108;8, 2635-2642 (2019), [doi: 10.1016/j.xphs.2019.03.017, LillOA]
2. M. Latreche, J.-F. willart, M. Guerain, F. Danede, A. Hedoux, Interest of molecular/crystalline dispersions for the determination of solubility curves of drugs into polymers, International Journal of Pharmaceutics 118626 (2019), [doi: 10.1016/j.ijpharm.2019.118626, LillOA]
1. A. Mahieu, J.-F. willart, M. Guerain, P. Derollez, F. Danede, M. Descamps, Structure determination of phase II of the antifungal drug griseofulvin by powder X-ray diffraction, Acta Crystallographica Section C Structural Chemistry 74, 321-324 (2018), [doi: 10.1107/S2053229618001845, LillOA]

Communications

7. A. Dupont, M. Guerain, J.-F. Willart, Cinétique de transformation de phase de produits pharmaceutiques sous broyage, Poster, Conférence International Matériaux 2022, Lille, France, Nov 2024 [LillOA]
6. A. Dupont, M. Guerain, J.-F. Willart, Effet de la température sur les cinétiques d'amorphisation des matériaux moléculaires par broyage mécanique, Poster, Conférence International Matériaux 2022, Lille, France, Nov 2024 [LillOA]
5. E. Dudognon, F. Danede, M. Guerain, Mécanismes des transformations de phases induites par broyage: cas d'un système moléculaire organique énantiotrope, Communication dans un congrès sans actes, Matériaux 2022, Lille, France, Oct 2022 [LillOA]
4. L.-V. Roca Paixao, F. Danede, M. Guerain, N. T. Correia, F. Affouard, Affinity Prediction And Synthesis Of Carbamazepine-based Cocrystals, Poster, 17th European Conference on Solid State Chemistry (ECSSC17), Villeneuve d'Ascq, France, Sep 2019 [LillOA]
3. M. Guerain, P. Derollez, C. Dejoie, N. T. Correia, F. Danede, F. Affouard, L. Paccou, Y. Guinet, A. Hedoux, C. Dejoie, Analyse structurale de matériaux moléculaires thérapeutiques cocristallisés par diffraction des rayons X, Communication dans un congrès sans actes, Rayons X et Matière 2019, Nancy, France, Nov 2019 [LillOA]
2. L.-V. Roca Paixao, F. Danede, M. Guerain, N. T. Correia, F. Affouard, Coformers predictions, synthesis and characterization of pharmaceutical cocrystals, Communication dans un congrès sans actes, 13th International Workshop of the Crystal Growth of Organic Material (CGOM13), Seoul, Corée du Sud, Aou 2018 [LillOA]
1. L.-V. Roca Paixao, F. Danede, M. Guerain, N. T. Correia, F. Affouard, SYNTHESE ET CARACTERISATION DE CO-CRISTAUX INTERET PHARMACEUTIQUE, Poster, Rayons X et matière, Villeneuve d'Ascq, France, Nov 2017 [LillOA]