UMET - Liste des publications de Jean-François WILLART

Book contributions

3. M. Descamps, E. Dudognon, J.-F. willart, The amorphous state, in Polymorphism in the Pharmaceutical Industry Solid Form and Drug Development [R. Hilfiker, M. von Raumer (eds)], Wiley-VCH pp. p. 189-240 (2019) [LillOA]
2. M. Descamps, E. Dudognon, J.-F. willart, The Amorphous State, in Polymorphism in the Pharmaceutical Industry, Wiley-VCH Verlag GmbH & Co. KGaA pp. 189-239 (2018) [LillOA]
1. M. Descamps, J.-F. willart, Some facets of molecular disorder in crystalline and amorphous pharmaceutical, in Disordered Pharmaceutical materials [M. Descamps (eds)], Wiley-VCH pp. 1-56 (2016) [LillOA]

Publications in international research journals

• 2024
  69. Y. Bedulho das Lages, N. Milanino, J. Verin, J.-F. Willart, F. Danede, C. Vincent, P. Bawuah, J. Zeitler, F. Siepmann, J. Siepmann, EVA implants for controlled drug delivery to the inner ear, International Journal of Pharmaceutics: X 8, 100271 (2024), [doi: 10.1016/j.ijpx.2024.100271, LillOA]
  68. D. Strojewski, S. Lalik, F. Danede, N. Górska, A. Deptuch, M. Marzec, J.-F. Willart, A. Krupa, Bosentan monohydrate and sildenafil base as two companions in enabling formulations, International journal of pharmaceutics 661, 124312 (2024), [doi: 10.1016/j.ijpharm.2024.124312, LillOA]
  67. F. Ramos, J.-F. Willart, C. Neut, K. Agossa, J. Siepmann, F. Siepmann, In-situ forming PLGA implants: Towards less toxic solvents., International Journal of Pharmaceutics: X 657, 124121 (2024), [doi: 10.1016/j.ijpharm.2024.124121, LillOA]
  66. L.-A. Lefol, P. Bawuah, J.A. Zeitler, J. Verin, F. Danede, J.-F. Willart, F. Siepmann, J. Siepmann, Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel., International Journal of Pharmaceutics: X 6, 100220 (2024), [doi: 10.1016/j.ijpx.2023.100220, LillOA]
• 2023
  65. A. Krupa, F. Danede, D. Majda, A. Węgrzyn, D. Strojewski, I. Kondera, J.-F. willart, High energy ball milling vs. nano spray drying in the development of supersaturated systems loaded with bosentan, European Journal of Pharmaceutics and Biopharmaceutics 188, 137-146 (2023), [doi: 10.1016/j.ejpb.2023.05.014, LillOA]
  64. S. Wachowiak, F. Danede, J.-F. Willart, F. Siepmann, J. Siepmann, M. Hamoudi, PLGA implants for controlled dexamethasone delivery: Impact of the polymer chemistry, Journal of Drug Delivery Science and Technology 86, 104648 (2023), [doi: 10.1016/j.jddst.2023.104648, LillOA]
  63. M. Latreche, J.-F. willart, Analysis of the Dissolution Mechanism of Drugs into Polymers: The Case of the PVP/Sulindac System, Pharmaceutics 15;5, 1505 (2023), [doi: 10.3390/pharmaceutics15051505, LillOA]
  62. C. Henaff, J. Siepmann, F. Siepmann, F. Danede, M.-N. Avettand-Fènoël, J. Verin, A. Fadel, J.-F. Willart, Exploration of the physical states of riboflavin (free base) by mechanical milling, International journal of pharmaceutics 645, 123416 (2023), [doi: 10.1016/j.ijpharm.2023.123416, LillOA]
  61. T. Rongthong, A. Qnouch, M. Maue Gehrke, L. Paccou, P. Oliveira, F. Danede, J. Verin, C. Vincent, J.-F. Willart, F. Siepmann, J. Siepmann, Silicone matrices for controlled dexamethasone release: toward a better understanding of the underlying mass transport mechanisms., Regenerative Biomaterials 10, rbad008 (2023), [doi: 10.1093/rb/rbad008, LillOA]
• 2022
  60. T. Rongthong, A. Qnouch, M.M. Gehrke, F. Danede, J.-F. Willart, P.F.M. De Oliveira, L. Paccou, G. Tourrel, P. Stahl, J. Verin, P. Toulemonde, C. Vincent, F. Siepmann, J. Siepmann, Long term behavior of dexamethasone-loaded cochlear implants: In vitro & in vivo, International Journal of Pharmaceutics: X 4, 100141 (2022), [doi: 10.1016/j.ijpx.2022.100141, LillOA]
  59. C. Bassand, L. Benabed, J. Verin, F. Danede, L. Lefol, J.-F. willart, F. Siepmann, J. Siepmann, L. Benabed, Hot melt extruded PLGA implants loaded with ibuprofen: How heat exposure alters the physical drug state, Journal of Drug Delivery Science and Technology 73, 103432 (2022), [doi: 10.1016/j.jddst.2022.103432, LillOA]
  58. J.-F. willart, S. Ouerghemmi, N. Descamps, P. Heijboer, L. Paccou, F. Danede, M. Descamps, The melting of glucose, International Journal of Pharmaceutics 626, 122185 (2022), [doi: 10.1016/j.ijpharm.2022.122185, LillOA]
  57. A. Krupa, F. Danede, A. Węgrzyn, D. Majda, J.-F. willart, Thinking of bosentan repurposing – A study on dehydration and amorphization, International Journal of Pharmaceutics 622, 121846 (2022), [doi: 10.1016/j.ijpharm.2022.121846, LillOA]
  56. A. Dupont, M. Guerain, F. Danede, J.-F. willart, Evidence of transient amorphization during the polymorphic transformation of sorbitol induced by milling, International Journal of Pharmaceutics 121929 (2022), [doi: 10.1016/j.ijpharm.2022.121929, LillOA]
• 2021
  55. Y. Benzine, F. Siepmann, C. Neut, F. Danede, J.-F. willart, J. Siepmann, y. karrout, Injection-molded capsule bodies and caps based on polymer blends for controlled drug delivery, European Journal of Pharmaceutics and Biopharmaceutics 168, 1-14 (2021), [doi: 10.1016/j.ejpb.2021.08.007, LillOA]
  54. M. Guerain, F. Affouard, C. Henaff, C. Dejoie, F. Danede, J. Siepmann, F. Siepmann, J.-F. Willart, Structure determination of riboflavin by synchrotron high-resolution powder X-ray diffraction, Acta Crystallographica Section C Structural Chemistry 77;12, 800-806 (2021), [doi: 10.1107/s2053229621012171, LillOA]
  53. A. Qnouch, V. Solarczyk, J. Verin, G. Tourrel, P. Stahl, F. Danede, J.-F. Willart, P.-E. Lemesre, C. Vincent, J. Siepmann, F. Siepmann, Dexamethasone-loaded cochlear implants: How to provide a desired “burst release”, International Journal of Pharmaceutics: X 100088 (2021), [doi: 10.1016/j.ijpx.2021.100088, LillOA]
• 2020
  52. O. Cantin, F. Siepmann, J.-F. Willart, F. Danede, J. Siepmann, Y. Karrout, PEO hot melt extrudates for controlled drug delivery: Importance of the type of drug and loading, Journal of Drug Delivery Science and Technology 102238 (2020), [doi: 10.1016/j.jddst.2020.102238, LillOA]
  51. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, F. Danede, A. Hedoux, Contribution of low-frequency Raman spectroscopy to determine the solubility curves of drugs in polymers: The case of paracetamol/PVP, European Journal of Pharmaceutics and Biopharmaceutics 154, 222-227 (2020), [doi: 10.1016/j.ejpb.2020.07.012, LillOA]
  50. A. Dupont, M. Guerain, F. Danede, L. Paccou, Y. Guinet, A. Hedoux, J.-F. willart, Kinetics and mechanism of polymorphic transformation of sorbitol under mechanical milling, International Journal of Pharmaceutics 590, 119902 (2020), [doi: 10.1016/j.ijpharm.2020.119902, LillOA]
  49. F. Ngono, G.J. Cuello, M. Jimenez-Ruiz, J.-F. Willart, M. Guerain, A.R. Wildes, A. Stunault, M. Hamoudi, F. Affouard, Morphological and structural properties of amorphous lactulose studied by scanning electron microscopy, polarised neutron scattering, and molecular dynamics simulations, Molecular Pharmaceutics 17, 10-20 (2020), [doi: 10.1021/acs.molpharmaceut.9b00767, LillOA]
  48. F. Ngono, J.-F. Willart, G.J. Cuello, M. Jimenez-Ruiz, M. Hamoudi, F. Affouard, Impact of amorphisation methods on the physico-chemical properties of amorphous lactulose, Molecular Pharmaceutics 17, 1-9 (2020), [doi: 10.1021/acs.molpharmaceut.9b00740, LillOA]
• 2019
  47. M. Latreche, J.-F. willart, M. Guerain, A. Hedoux, F. Danede, Using Milling to Explore Physical States: The Amorphous and Polymorphic Forms of Sulindac, Journal of Pharmaceutical Sciences 108;8, 2635-2642 (2019), [doi: 10.1016/j.xphs.2019.03.017, LillOA]
  46. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, A. Hedoux, Polymorphism versus devitrification mechanism: Low-wavenumber Raman investigations in sulindac, International Journal of Pharmaceutics 567, 118476 (2019), [doi: 10.1016/j.ijpharm.2019.118476, LillOA]
  45. M. Latreche, J.-F. willart, M. Guerain, F. Danede, A. Hedoux, Interest of molecular/crystalline dispersions for the determination of solubility curves of drugs into polymers, International Journal of Pharmaceutics 118626 (2019), [doi: 10.1016/j.ijpharm.2019.118626, LillOA]
  44. F. Tamani, C. Bassand, M. Hamoudi, F. Danede, J.-F. Willart, F. Siepmann, J. Siepmann, Mechanistic explanation of the (up to) 3 release phases of PLGA microparticles: Diprophylline dispersions, International Journal of Pharmaceutics 118819 (2019), [doi: 10.1016/j.ijpharm.2019.118819, LillOA]
  43. F. Tamani, M. Hamoudi, F. Danede, J.-F. Willart, F. Siepmann, J. Siepmann, Towards a better understanding of the release mechanisms of caffeine from PLGA microparticles, Journal of Applied Polymer Science 48710 (2019), [doi: 10.1002/app.48710, LillOA]
  42. Y. Benzine, F. Siepmann, C. Neut, F. Danede, J.-F. Willart, J. Siepmann, Y. Karrout, Hot melt extruded polysaccharide blends for controlled drug delivery, Journal of Drug Delivery Science and Technology 54, 101317 (2019), [doi: 10.1016/j.jddst.2019.101317, LillOA]
  41. F. Ngono Mebenga, J.-F. willart, G.J. Cuello, M. Jimenez-Ruiz, F. Affouard, Lactulose: a model system to investigate solid state amorphization induced by milling, Journal of Pharmaceutical Sciences 108, 880-887 (2019), [doi: 10.1016/j.xphs.2018.09.013, LillOA]
• 2018
  40. P.F.M. Oliveira, J.-F. willart, J. Siepmann, F. Siepmann, M. Descamps, Using Milling To Explore Physical States: The Amorphous and Polymorphic Forms of Dexamethasone, Crystal Growth & Design 18, 1748-1757 (2018), [doi: 10.1021/acs.cgd.7b01664, LillOA]
  39. M. Descamps, J.-F. willart, Scaling laws and size effects for amorphous crystallization kinetics: Constraints imposed by nucleation and growth specificities, International journal of pharmaceutics 542, 186-195 (2018), [doi: 10.1016/j.ijpharm.2018.03.001, LillOA]
  38. A. Mahieu, J.-F. willart, M. Guerain, P. Derollez, F. Danede, M. Descamps, Structure determination of phase II of the antifungal drug griseofulvin by powder X-ray diffraction, Acta Crystallographica Section C Structural Chemistry 74, 321-324 (2018), [doi: 10.1107/S2053229618001845, LillOA]
  37. E. Elisei, J.-F. willart, F. Danede, J. Siepmann, F. Siepmann, M. Descamps, Crystalline Polymorphism Emerging From a Milling-Induced Amorphous Form: The Case of Chlorhexidine Dihydrochloride, Journal of Pharmaceutical Sciences 107, 121-126 (2018), [doi: 10.1016/j.xphs.2017.07.003, LillOA]
• 2017
  36. J.-F. willart, E. Dudognon, A. Mahieu, M.D. Eddleston, W. Jones, M. Descamps, The role of cracks in the crystal nucleation process of amorphous griseofulvin, The European Physical Journal Special Topics 226, 837-847 (2017), [doi: 10.1140/epjst/e2016-60358-y, LillOA]
  35. P. Martinetto, P. Bordet, M. Descamps, E. Dudognon, W. Pagnoux, J.-F. Willart, Structural Transformations of d -Mannitol Induced by in Situ Milling Using Real Time Powder Synchrotron Radiation Diffraction, Crystal Growth & Design 17, 6111-6122 (2017), [doi: 10.1021/acs.cgd.7b01283, LillOA]
  34. M. Hamoudi-Ben Yelles, V. Tran Tan, F. Danede, J.-F. Willart, J. Siepmann, PLGA implants: How Poloxamer/PEO addition slows down or accelerates polymer degradation and drug release, Journal of controlled release 253, 19-29 (2017), [doi: 10.1016/j.jconrel.2017.03.009, LillOA]
• 2016
  33. P. Bordet, A. Bytchkov, M. Descamps, E. Dudognon, E. Elkaïm, P. Martinetto, W. Pagnoux, A. Poulain, J.-F. willart, Solid State Amorphization of β-Trehalose: A Structural Investigation Using Synchrotron Powder Diffraction and PDF Analysis, Crystal Growth & Design 16, 4547-4558 (2016), [doi: 10.1021/acs.cgd.6b00660, LillOA]
  32. H. Gasmi, F. Siepmann, M. Hamoudi, F. Danede, J. Verin, J.-F. willart, J. Siepmann, Towards a better understanding of the different release phases from PLGA microparticles: Dexamethasone-loaded systems, International journal of pharmaceutics 514, 189-199 (2016), [doi: 10.1016/j.ijpharm.2016.08.032, LillOA]
  31. O. Cantin, F. Siepmann, F. Danede, J.-F. Willart, Y. Karrout, J. Siepmann, PEO hot melt extrudates for controlled drug delivery: Importance of the molecular weight, Journal of Drug Delivery Science and Technology 36, 130-140 (2016), [doi: 10.1016/j.jddst.2016.09.003, LillOA]
  30. M. Gehrke, J. Sircoglou, D. Gnansia, G. Tourrel, J.-F. willart, F. Danede, E. Lacante, C. Vincent, F. Siepmann, J. Siepmann, Ear Cubes for local controlled drug delivery to the inner ear, International journal of pharmaceutics 509, 85-94 (2016), [doi: 10.1016/j.ijpharm.2016.04.003, LillOA]
  29. A. Krupa, M. Descamps, J.-F. willart, R. Jachowicz, F. Danede, High energy ball milling and supercritical carbon dioxide impregnation as co-processing methods to improve dissolution of tadalafil, European Journal of Pharmaceutical Sciences 95, 130-137 (2016), [doi: 10.1016/j.ejps.2016.05.007, LillOA]
  28. A. Krupa, M. Descamps, J.-F. willart, B. Strach, E. Wyska, R. Jachowicz, F. Danede, High-Energy Ball Milling as Green Process To Vitrify Tadalafil and Improve Bioavailability, Molecular Pharmaceutics 13, 3891-3902 (2016), [doi: 10.1021/acs.molpharmaceut.6b00688, LillOA]
  27. Y. Guinet, L. Paccou, F. Danede, J.-F. willart, P. Derollez, A. Hedoux, Comparison of amorphous states prepared by melt-quenching and cryomilling polymorphs of carbamazepine, International journal of pharmaceutics 509, 305-313 (2016), [doi: 10.1016/j.ijpharm.2016.05.050, LillOA]
  26. M. Descamps, J.-F. willart, Perspectives on the amorphisation/milling relationship in pharmaceutical materials, Advanced Drug Delivery Reviews 100, 51-66 (2016), [doi: 10.1016/j.addr.2016.01.011, LillOA]
  25. N. Tabary, M.J. Garcia Fernandez, F. Danede, M. Descamps, B. Martel, J.-F. willart, Determination of the glass transition temperature of cyclodextrin polymers, Carbohydrate polymers 148, 172-180 (2016), [doi: 10.1016/j.carbpol.2016.04.032, LillOA]
• 2015
  24. M. Descamps, A. Aumelas, S. Desprez, J.-F. willart, The amorphous state of pharmaceuticals obtained or transformed by milling: Sub-Tg features and rejuvenation, Journal of Non-Crystalline Solids 407, 72-80 (2015), [doi: 10.1016/j.jnoncrysol.2014.08.055, LillOA]
  23. H. Gasmi, J.-F. willart, F. Danede, M. Hamoudi, J. Siepmann, F. Siepmann, Importance of PLGA microparticle swelling for the control of prilocaine release, Journal of Drug Delivery Science and Technology 30, 123-132 (2015), [doi: 10.1016/j.jddst.2015.10.009, LillOA]
  22. M. Nieto-Bobadilla, F. Siepmann, M. Djouina, L. Dubuquoy, N. Tesse, J.-F. willart, L. Dubreuil, J. Siepmann, C. Neut, Controlled delivery of a new broad spectrum antibacterial agent against colitis: In vitro and in vivo performance, European journal of pharmaceutics and biopharmaceutics 96, 152-161 (2015), [doi: 10.1016/j.ejpb.2015.07.012, LillOA]
  21. A.-K. Vynckier, H. Lin, J. Zeitler, J.-F. willart, E. Bongaers, J. Voorspoels, J. Remon, C. Vervaet, Calendering as a direct shaping tool for the continuous production of fixed-dose combination products via co-extrusion, European journal of pharmaceutics and biopharmaceutics 96, 125-131 (2015), [doi: 10.1016/j.ejpb.2015.07.023, LillOA]
  20. E. Gué, S. Florin Muschert, J.-F. Willart, F. Danede, M. Descamps, E. Delcourt-Debruyne, J. Siepmann, Accelerated fenofibrate release from spray-dried microparticles based on polymer blends, Journal of Drug Delivery Science and Technology 24, 185-190 (2015), [doi: 10.1016/S1773-2247(14)50030-5, LillOA]
  19. Y. Jallouli, J.-F. willart, F. Siepmann, M. Descamps, F. Danede, J. Siepmann, Preparation of polymeric fenofibrate formulations with accelerated drug release: Solvent evaporation versus co-grinding, Journal of Drug Delivery Science and Technology 30, 397-407 (2015), [doi: 10.1016/j.jddst.2015.07.013, LillOA]
  18. E. Elisei, M. Filibian, P. Carretta, S. Colombo Serra, F. Tedoldi, J.-F. willart, M. Descamps, A. Cesàro, Dynamic nuclear polarization of a glassy matrix prepared by solid state mechanochemical amorphization of crystalline substances, Chemical Communications 51, 2080-2083 (2015), [doi: 10.1039/C4CC08348B, LillOA]
• 2014
  17. E. Gue, S. Florin Muschert, J.-F. Willart, F. Danede, E. Delcourt-Debruyne, M. Descamps, J. Siepmann, Accelerated ketoprofen release from spray-dried polymeric particles: importance of phase transitions and excipient distribution, Drug development and industrial pharmacy 41, 838-850 (2014), [doi: 10.3109/03639045.2014.908902, LillOA]
• 2013
  16. A. Mahieu, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, A new protocol to determine the solubility of drugs into polymer matrixes, Molecular Pharmaceutics 10, 560-566 (2013), [doi: 10.1021/mp3002254, LillOA]
  15. A. Mahieu, J.-F. willart, E. Dudognon, M.D. Eddleston, W. Jones, F. Danede, M. Descamps, On the polymorphism of griseofulvin: Identification of two additional polymorphs, Journal of Pharmaceutical Sciences 102, 462-468 (2013), [doi: 10.1002/jps.23349, LillOA]
  14. N. Dujardin, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, Mechanism of Solid State Amorphization of Glucose upon Milling, The Journal of Physical Chemistry B 117, 1437-1443 (2013), [doi: 10.1021/jp3069267, LillOA]
  13. E. Gué, J.-F. Willart, S. Florin Muschert, F. Danede, E. Delcourt, M. Descamps, J. Siepmann, Accelerated ketoprofen release from polymeric matrices: Importance of the homogeneity/heterogeneity of excipient distribution, International journal of pharmaceutics 457, 298-307 (2013), [doi: 10.1016/j.ijpharm.2013.09.023, LillOA]
  12. J.-F. willart, M. Durand, L.-E. Briggner, A. Marx, F. Danede, M. Descamps, Solid-state amorphization of linaprazan by mechanical milling and evidence of polymorphism, Journal of Pharmaceutical Sciences 102, 2214-2220 (2013), [doi: 10.1002/jps.23573, LillOA]
• 2012
  11. O. Syll, B. Richard, J.-F. willart, M. Descamps, P. Schuck, G. Delaplace, R. Jeantet, Rehydration behaviour and ageing of dairy powders assessed by calorimetric measurements, Innovative Food Science & Emerging Technologies 14, 139-145 (2012), [doi: 10.1016/j.ifset.2012.01.001, LillOA]
  10. J.-F. willart, L. Carpentier, F. Danede, M. Descamps, Solid-state vitrification of crystalline griseofulvin by mechanical milling, Journal of Pharmaceutical Sciences 101, 1570-1577 (2012), [doi: 10.1002/jps.23041, LillOA]
• 2011
  9. N. Tabary, A. Mahieu, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, m. Bacquet, B. Martel, Characterization of the hidden glass transition of amorphous cyclomaltoheptaose, Carbohydrate research 346, 2193-2199 (2011), [doi: 10.1016/j.carres.2011.07.010, LillOA]
  8. N. Dujardin, E. Dudognon, J.-F. willart, A. Hedoux, Y. Guinet, L. Paccou, M. Descamps, Solid state mutarotation of glucose, J. Phys. Chem. B 115, 1698-1705 (2011), [doi: 10.1021/jp109382j, LillOA]
  7. V. Caron, J.-F. willart, R. Lefort, P. Derollez, F. Danede, M. Descamps, Solid state amorphization kinetic of alpha lactose upon mechanical milling, Carbohydrate research 346, 2622-2628 (2011), [doi: 10.1016/j.carres.2011.09.004, LillOA]
  6. F. Kreye, F. Siepmann, A. Zimmer, J.-F. willart, M. Descamps, J. Siepmann, Controlled release implants based on cast lipid blends, European Journal of Pharmaceutical Sciences 43, 78 (2011), [doi: 10.1016/j.ejps.2011.03.013, LillOA]
  5. F. Kreye, F. Siepmann, J.-F. willart, M. Descamps, J. Siepmann, Drug release mechanisms of cast lipid implants, European journal of pharmaceutics and biopharmaceutics 78, 394-400 (2011), [doi: 10.1016/j.ejpb.2011.02.011, LillOA]
  4. F. Kreye, F. Siepmann, A. Zimmer, J.-F. willart, M. Descamps, J. Siepmann, Cast lipid implants for controlled drug delivery: Importance of the tempering conditions, Journal of Pharmaceutical Sciences 100, 3471-3481 (2011), [doi: 10.1002/jps.22574, LillOA]
• 2010
  3. N. Dujardin, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, First obtaining of glass solutions and phase diagram of glucose with fully tunable anomeric concentration, Journal of Pharmaceutical Sciences 99, 1476 - 1483 (2010), [doi: 10.1002/jps.21900, LillOA]
  2. J.-F. willart, N. Dujardin, E. Dudognon, F. Danede, M. Descamps, Amorphization of sugar hydrates upon milling, Carbohydrate research 345, 1613 (2010), [doi: 10.1016/j.carres.2010.04.014, LillOA]
  1. D. Klose, F. Siepmann, J.-F. willart, M. Descamps, J. Siepmann, Drug release from PLGA-based microparticles: Effects of the "microparticle / bulk fluid" ratio, International journal of pharmaceutics 383, 123-131 (2010), [doi: 10.1016/j.ijpharm.2009.09.012, LillOA]