Florence DANEDE

Ingénieur en techniques des sciences des matériaux/caractérisation Université de Lille

Bâtiment P5 - 227
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33 (0)3 20 43 47 08
Fax: +33 (0)3 20 43 40 84
Courriel : Envoyer un mel à Florence DANEDE
Identifiant ORCID : 0000-0001-5139-9187

Equipe: Matériaux moléculaires et thérapeutiques

Activité

Diffraction des rayons X sur poudre Analyses thermiques (DSC, DSC modulée, ATG) Préparation des échantillons Personne Compétente en Radioprotection

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ATG Q500 (TA Instruments)

Equipe : Matériaux moléculaires et thérapeutiques.

Correspondant : Florence DANEDE.

Caractérisation des pertes de solvants et dégradations dans les matériaux moléculaires
Gamme de température : de 30°C à 550°C

 

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Diffractomètre à Rayons X sur poudres, X'Pert Pro (Panalytical)

Equipe : Matériaux moléculaires et thérapeutiques.

Plateforme : Plateau d’analyses par diffraction des Rayons X.

Correspondants : Mathieu GUERAIN, Florence DANEDE.

Etude de l'organisation structurale de matériaux moléculaires : états  vitreux et transformations de phases induites par des contraintes externes (variations de température, broyage, vieillissement, ...)
Caractéristiques techniques

• Tube au cuivre
• Mesures en transmission sur échantillons conditionnés en capillaires avec la possibilité de varier la température de l'ambiante à 300°C ( four Huber)
• Mesures en réflexion sur plaquettes avec la possibilité de varier la température de -150°C à 400°C (chambre Anton Paar TTK 450)

 

Responsabilité d'instruments

Derniers dépôts dans dans LillOA (Lille Open Archive)

Publications

21. N. Zupan, I. Yous, F. Danede, J. Verin, M. Kouach, C. Foulon, E. Dudognon, S. Florin Muschert, Impact of Hot-Melt Extrusion on Glibenclamide's Physical and Chemical States and Dissolution Behavior: Case Studies with Three Polymer Blend Matrices., Pharmaceutics 16;8, 1071 (2024), [doi: 10.3390/pharmaceutics16081071, LillOA]
20. Y. Bedulho das Lages, N. Milanino, J. Verin, J.-F. Willart, F. Danede, C. Vincent, P. Bawuah, J. Zeitler, F. Siepmann, J. Siepmann, EVA implants for controlled drug delivery to the inner ear, International Journal of Pharmaceutics: X 8, 100271 (2024), [doi: 10.1016/j.ijpx.2024.100271, LillOA]
19. D. Strojewski, S. Lalik, F. Danede, N. Górska, A. Deptuch, M. Marzec, J.-F. Willart, A. Krupa, Bosentan monohydrate and sildenafil base as two companions in enabling formulations, International journal of pharmaceutics 661, 124312 (2024), [doi: 10.1016/j.ijpharm.2024.124312, LillOA]
18. M. Khalaji, M.K. Dudek, L. Paccou, F. Danede, Y. Guinet, A. Hedoux, Description of an original molecular ordering process into a disordered crystalline form: the atypical low-temperature transformation of the disordered form III of linezolid, Physical Chemistry Chemical Physics 26;30, 20709-20716 (2024), [doi: 10.1039/D4CP02104E, LillOA]
17. L.-A. Lefol, P. Bawuah, J.A. Zeitler, J. Verin, F. Danede, J.-F. Willart, F. Siepmann, J. Siepmann, Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel., International Journal of Pharmaceutics: X 6, 100220 (2024), [doi: 10.1016/j.ijpx.2023.100220, LillOA]
16. T. Cordeiro, I. Matos, F. Danede, J.C. Sotomayor, I.M. Fonseca, M.C. Corvo, M. Dionísio, M.T. Viciosa, F. Affouard, N. T. Correia, Evidence of Strong Guest–Host Interactions in Simvastatin Loaded in Mesoporous Silica MCM-41, Pharmaceutics 15;5, 1320 (2023), [doi: 10.3390/pharmaceutics15051320, LillOA]
15. L.-V. Roca Paixao, N. T. Correia, F. Danede, M. Guerain, F. Affouard, Carbamazepine/Tartaric Acid Cocrystalline Forms: When Stoichiometry and Synthesis Method Matter, Crystal Growth & Design 23;3, 1355-1369 (2023), [doi: 10.1021/acs.cgd.2c00859, LillOA]
14. A. Barrera, C. Binet, F. Danede, J.-F. Tahon, B. Ouddane, F. Dubois, P. Supiot, C. Foissac, U. Maschke, Chemical Characterization and Thermal Analysis of Recovered Liquid Crystals, Crystals 13;7, 1064 (2023), [doi: 10.3390/cryst13071064, LillOA]
13. A. Krupa, F. Danede, D. Majda, A. Węgrzyn, D. Strojewski, I. Kondera, J.-F. Willart, High energy ball milling vs. nano spray drying in the development of supersaturated systems loaded with bosentan, European Journal of Pharmaceutics and Biopharmaceutics 188, 137-146 (2023), [doi: 10.1016/j.ejpb.2023.05.014, LillOA]
12. S. Wachowiak, F. Danede, J.-F. Willart, F. Siepmann, J. Siepmann, M. Hamoudi, PLGA implants for controlled dexamethasone delivery: Impact of the polymer chemistry, Journal of Drug Delivery Science and Technology 86, 104648 (2023), [doi: 10.1016/j.jddst.2023.104648, LillOA]
11. C. Henaff, J. Siepmann, F. Siepmann, F. Danede, M.-N. Avettand-Fènoël, J. Verin, A. Fadel, J.-F. Willart, Exploration of the physical states of riboflavin (free base) by mechanical milling, International journal of pharmaceutics 645, 123416 (2023), [doi: 10.1016/j.ijpharm.2023.123416, LillOA]
10. T. Rongthong, A. Qnouch, M. Maue Gehrke, L. Paccou, P. Oliveira, F. Danede, J. Verin, C. Vincent, J.-F. Willart, F. Siepmann, J. Siepmann, Silicone matrices for controlled dexamethasone release: toward a better understanding of the underlying mass transport mechanisms., Regenerative Biomaterials 10, rbad008 (2023), [doi: 10.1093/rb/rbad008, LillOA]
9. L.-V. Roca Paixao, N. T. Correia, F. Danede, M.T. Viciosa, A.L. Morritt, Y.Z. Khimyak, F. Affouard, Nature of the Structural and Dynamical Disorder in Organic Cocrystals with a True Nanometric Size Channel-Like Architecture, Crystal Growth & Design 23;1, 120-133 (2023), [doi: 10.1021/acs.cgd.2c00815, LillOA]
8. T. Rongthong, A. Qnouch, M.M. Gehrke, F. Danede, J.-F. Willart, P.F.M. De Oliveira, L. Paccou, G. Tourrel, P. Stahl, J. Verin, P. Toulemonde, C. Vincent, F. Siepmann, J. Siepmann, Long term behavior of dexamethasone-loaded cochlear implants: In vitro & in vivo, International Journal of Pharmaceutics: X 4, 100141 (2022), [doi: 10.1016/j.ijpx.2022.100141, LillOA]
7. Y. Guinet, L. Paccou, F. Danede, P. Derollez, A. Hedoux, Identification of incommensurability in L-leucine: can lattice instabilities be considered as general phenomena in hydrophobic amino acids?, Physical Chemistry Chemical Physics 24, 27023-27030 (2022), [doi: 10.1039/d2cp00989g, LillOA]
6. C. Bassand, L. Benabed, J. Verin, F. Danede, L. Lefol, J.-F. willart, F. Siepmann, J. Siepmann, L. Benabed, Hot melt extruded PLGA implants loaded with ibuprofen: How heat exposure alters the physical drug state, Journal of Drug Delivery Science and Technology 73, 103432 (2022), [doi: 10.1016/j.jddst.2022.103432, LillOA]
5. J.-F. willart, S. Ouerghemmi, N. Descamps, P. Heijboer, L. Paccou, F. Danede, M. Descamps, The melting of glucose, International Journal of Pharmaceutics 626, 122185 (2022), [doi: 10.1016/j.ijpharm.2022.122185, LillOA]
4. A. Krupa, F. Danede, A. Węgrzyn, D. Majda, J.-F. willart, Thinking of bosentan repurposing – A study on dehydration and amorphization, International Journal of Pharmaceutics 622, 121846 (2022), [doi: 10.1016/j.ijpharm.2022.121846, LillOA]
3. A. Dupont, M. Guerain, F. Danede, J.-F. willart, Evidence of transient amorphization during the polymorphic transformation of sorbitol induced by milling, International Journal of Pharmaceutics 121929 (2022), [doi: 10.1016/j.ijpharm.2022.121929, LillOA]
2. Y. Benzine, F. Siepmann, C. Neut, F. Danede, J.-F. willart, J. Siepmann, y. karrout, Injection-molded capsule bodies and caps based on polymer blends for controlled drug delivery, European Journal of Pharmaceutics and Biopharmaceutics 168, 1-14 (2021), [doi: 10.1016/j.ejpb.2021.08.007, LillOA]
1. P. d’Orey, T. Cordeiro, M.A.O. Lourenço, I. Matos, F. Danede, J.C. Sotomayor, I.M. Fonseca, P. Ferreira, N. T. Correia, M. Dionísio, How Molecular Mobility, Physical State, and Drug Distribution Influence the Naproxen Release Profile from Different Mesoporous Silica Matrices, Molecular Pharmaceutics 18;3, 898-914 (2021), [doi: 10.1021/acs.molpharmaceut.0c00908, LillOA]

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Communications

10. A. Krupa, F. Danede, A. Węgrzyn, J.-F. Willart, How to enhance the solubility of bosentan?, Poster, 13th Central European Symposium on Pharmaceutical Technology, Gdansk, Pologne, Mai 2025 [LillOA]
9. A. Krupa, F. Danede, I. Kondera, A. Węgrzyn, J.-F. Willart, The co-milled molecular alloys bosnetan / copovidone as a green way to create supersaturation in the git, Poster, AAPS PharmSci 360, Philadelphia, Etats-Unis d'Amérique, Mai 2025 [LillOA]
8. D. Strojewski, S. Lalik, F. Danede, M. Marzec, J.-F. Willart, A. Krupa, Design of co-amorphous fixed-dose combinations of bosentan and sildenafil base, Poster, 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Vienne (Austria), Autriche, Mai 2025 [LillOA]
7. Y. Bedulho Das Lages, N. Milanino, J. Verin, J.-F. Willart, F. Danede, C. Vincent, P. Bawuah, J. Zeitler, F. Siepmann, J. Siepmann, EVA implants for controlled drug delivery to the inner ear, Poster, 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Vienne (Austria), Autriche, Mai 2025 [LillOA]
6. L.-V. Roca Paixao, N. T. Correia, F. Danede, M.T. Viciosa, A. Morritt, Y.Z. Khimyak, F. Affouard, Nature of the disorder in organic cocrystals of pharmaceutical interest with a channel-like architecture, Conférence invitée, 9th International Discussion Meeting on Relaxations in Complex Systems (9 IDMRCS), Chiba, Japon, Aou 2023 [LillOA]
5. E. Dudognon, F. Danede, M. Guerain, Mécanismes des transformations de phases induites par broyage: cas d'un système moléculaire organique énantiotrope, Communication dans un congrès sans actes, Matériaux 2022, Lille, France, Oct 2022 [LillOA]
4. L.-V. Roca Paixao, F. Danede, N. T. Correia, F. Affouard, WHEN RESIDUAL WATER INFLUENCES THE COCRYSTALLIZATION OUTPUT: THE CARBAMAZEPINE AND TARTARIC ACID CASE, Communication dans un congrès sans actes, Journées SolvATE 2021, Lille, France, Déc 2021 [LillOA]
3. N. T. Correia, T. Cordeiro, F. Affouard, I. Matos, F. Danede, J. Sotomayor, M. Corvo, I. Fonseca, M. Dionísio, M.T. Viciosa, Simvastatine confinée dans MCM-41 : désordre dynamique, organisations/interactions moléculaires et leurs implications sur la vitesse de dissolution et le profil de libération, Poster, Conference Internationale "Matériaux 2022", Lille, France, Oct 2022 [LillOA]
2. N. T. Correia, L.-V. Roca Paixao, F. Danede, M.T. Viciosa, A.L. Morritt, Y.Z. Khimyak, F. Affouard, Dynamic Disorder in a Nano-Sized Channel-Shaped Pharmaceutical Cocrystal Architecture, Conférence invitée, 11th Conference on Broadband Dielectric Spectroscopy and its applications, San Sebastian, Espagne, Sep 2022 [LillOA]
1. L.-V. Roca Paixao, F. Danede, M. Guerain, N. T. Correia, F. Affouard, Affinity Prediction And Synthesis Of Carbamazepine-based Cocrystals, Poster, 17th European Conference on Solid State Chemistry (ECSSC17), Villeneuve d'Ascq, France, Sep 2019 [LillOA]

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