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Unité Matériaux et Transformations
CNRS UMR 8207 - Université de Lille

 
Jean-François WILLART
Directeur de recherche CNRS
Bâtiment P5 - 229
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33(0)3 20 43 68 34
Fax: +33 (0)3 20 43 40 84
Courriel Envoyer un mel à  Jean-François WILLART: Envoyer un mel à Jean-François WILLART
Identifiant ORCID 0000-0002-7911-3918
: 0000-0002-7911-3918

Recherche

Thème général : Etude des propriétés physiques des matériaux moléculaires hors équilibre: verres et transition vitreuse, métastabilité, cinétiques de transformations de phases. Thème spécifique actuel : amorphisation et transformations polymorphiques à l’état solide induites par broyage mécanique. Applications aux matériaux thérapeutiques et aux problématiques de la formulation pharmaceutique.

Thèses soutenues

Brevets

  1. 2017 - B. Martel, N. Blanchemain, M. P. Flament, J. F. Willart, N. Tabary, M. J. Garcia-Fernandez: Utilisation de fractions solubles, insolubles d'un polymère de cyclodextrine ou de leurs mélanges comme excipient dans un comprimé.
    Brevet français FR3040883 déposé le 14/09/2015 Numéro de publication internationale : WO2017/046506 A1

Derniers dépôts dans dans LillOA (Lille Open Archive)

Publications

  1. L.-A. Lefol, P. Bawuah, J.A. Zeitler, J. Verin, F. Danede, J.-F. Willart, F. Siepmann, J. Siepmann, Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel., International Journal of Pharmaceutics: X 6, 100220 (2024), [doi: 10.1016/j.ijpx.2023.100220, LillOA]
  2. A. Krupa, F. Danede, D. Majda, A. Węgrzyn, D. Strojewski, I. Kondera, J.-F. willart, High energy ball milling vs. nano spray drying in the development of supersaturated systems loaded with bosentan, European Journal of Pharmaceutics and Biopharmaceutics 188, 137-146 (2023), [doi: 10.1016/j.ejpb.2023.05.014, LillOA]
  3. S. Wachowiak, F. Danede, J.-F. willart, F. Siepmann, J. Siepmann, M. Hamoudi, PLGA implants for controlled dexamethasone delivery: Impact of the polymer chemistry, Journal of Drug Delivery Science and Technology 86, 104648 (2023), [doi: 10.1016/j.jddst.2023.104648, LillOA]
  4. M. Latreche, J.-F. willart, Analysis of the Dissolution Mechanism of Drugs into Polymers: The Case of the PVP/Sulindac System, Pharmaceutics 15;5, 1505 (2023), [doi: 10.3390/pharmaceutics15051505, LillOA]
  5. C. Henaff, J. Siepmann, F. Siepmann, F. Danede, M.-N. Avettand-Fènoël, J. VERIN, A. Fadel, J.-F. willart, Exploration of the physical states of riboflavin (free base) by mechanical milling, International journal of pharmaceutics 645, 123416 (2023), [doi: 10.1016/j.ijpharm.2023.123416, LillOA]
  6. T. Rongthong, A. Qnouch, M. Maue Gehrke, L. Paccou, P. Oliveira, F. Danede, J. VERIN, C. Vincent, J.-F. willart, F. Siepmann, J. Siepmann, Silicone matrices for controlled dexamethasone release: toward a better understanding of the underlying mass transport mechanisms., Regenerative Biomaterials 10, rbad008 (2023), [doi: 10.1093/rb/rbad008, LillOA]
  7. T. Rongthong, A. Qnouch, M.M. Gehrke, F. Danede, J.-F. willart, P.F.M. De Oliveira, L. Paccou, G. Tourrel, P. Stahl, J. VERIN, P. Toulemonde, C. Vincent, F. Siepmann, J. Siepmann, Long term behavior of dexamethasone-loaded cochlear implants: In vitro & in vivo, International Journal of Pharmaceutics: X 4, 100141 (2022), [doi: 10.1016/j.ijpx.2022.100141, LillOA]
  8. C. Bassand, L. Benabed, J. Verin, F. Danede, L. Lefol, J.-F. willart, F. Siepmann, J. Siepmann, L. Benabed, Hot melt extruded PLGA implants loaded with ibuprofen: How heat exposure alters the physical drug state, Journal of Drug Delivery Science and Technology 73, 103432 (2022), [doi: 10.1016/j.jddst.2022.103432, LillOA]
  9. J.-F. willart, S. Ouerghemmi, N. Descamps, P. Heijboer, L. Paccou, F. Danede, M. Descamps, The melting of glucose, International Journal of Pharmaceutics 626, 122185 (2022), [doi: 10.1016/j.ijpharm.2022.122185, LillOA]
  10. A. Krupa, F. Danede, A. Węgrzyn, D. Majda, J.-F. willart, Thinking of bosentan repurposing – A study on dehydration and amorphization, International Journal of Pharmaceutics 622, 121846 (2022), [doi: 10.1016/j.ijpharm.2022.121846, LillOA]
  11. A. Dupont, M. Guerain, F. Danede, J.-F. willart, Evidence of transient amorphization during the polymorphic transformation of sorbitol induced by milling, International Journal of Pharmaceutics 121929 (2022), [doi: 10.1016/j.ijpharm.2022.121929, LillOA]
  12. Y. Benzine, F. Siepmann, C. Neut, F. Danede, J.-F. willart, J. Siepmann, y. karrout, Injection-molded capsule bodies and caps based on polymer blends for controlled drug delivery, European Journal of Pharmaceutics and Biopharmaceutics 168, 1-14 (2021), [doi: 10.1016/j.ejpb.2021.08.007, LillOA]
  13. M. Guerain, F. Affouard, C. Henaff, C. Dejoie, F. Danede, J. Siepmann, F. Siepmann, J.-F. willart, Structure determination of riboflavin by synchrotron high-resolution powder X-ray diffraction, Acta Crystallographica Section C Structural Chemistry 77;12, 800-806 (2021), [doi: 10.1107/s2053229621012171, LillOA]
  14. A. Qnouch, V. Solarczyk, J. Verin, G. Tourrel, P. Stahl, F. Danede, J.-F. willart, P.-E. Lemesre, C. Vincent, J. Siepmann, F. Siepmann, Dexamethasone-loaded cochlear implants: How to provide a desired “burst release”, International Journal of Pharmaceutics: X 100088 (2021), [doi: 10.1016/j.ijpx.2021.100088, LillOA]
  15. O. Cantin, F. Siepmann, J.-F. willart, F. Danede, J. Siepmann, y. karrout, PEO hot melt extrudates for controlled drug delivery: Importance of the type of drug and loading, Journal of Drug Delivery Science and Technology 102238 (2020), [doi: 10.1016/j.jddst.2020.102238, LillOA]
  16. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, F. Danede, A. Hedoux, Contribution of low-frequency Raman spectroscopy to determine the solubility curves of drugs in polymers: The case of paracetamol/PVP, European Journal of Pharmaceutics and Biopharmaceutics 154, 222-227 (2020), [doi: 10.1016/j.ejpb.2020.07.012, LillOA]
  17. A. Dupont, M. Guerain, F. Danede, L. Paccou, Y. Guinet, A. Hedoux, J.-F. willart, Kinetics and mechanism of polymorphic transformation of sorbitol under mechanical milling, International Journal of Pharmaceutics 590, 119902 (2020), [doi: 10.1016/j.ijpharm.2020.119902, LillOA]
  18. F. Ngono, G.J. Cuello, M. Jimenez-Ruiz, J.-F. willart, M. Guerain, A.R. Wildes, A. Stunault, M. Hamoudi, F. Affouard, Morphological and structural properties of amorphous lactulose studied by scanning electron microscopy, polarised neutron scattering, and molecular dynamics simulations, Molecular Pharmaceutics 17, 10-20 (2020), [doi: 10.1021/acs.molpharmaceut.9b00767, LillOA]
  19. M. Latreche, J.-F. willart, M. Guerain, A. Hedoux, F. Danede, Using Milling to Explore Physical States: The Amorphous and Polymorphic Forms of Sulindac, Journal of Pharmaceutical Sciences 108;8, 2635-2642 (2019), [doi: 10.1016/j.xphs.2019.03.017, LillOA]
  20. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, A. Hedoux, Polymorphism versus devitrification mechanism: Low-wavenumber Raman investigations in sulindac, International Journal of Pharmaceutics 567, 118476 (2019), [doi: 10.1016/j.ijpharm.2019.118476, LillOA]
  21. M. Latreche, J.-F. willart, M. Guerain, F. Danede, A. Hedoux, Interest of molecular/crystalline dispersions for the determination of solubility curves of drugs into polymers, International Journal of Pharmaceutics 118626 (2019), [doi: 10.1016/j.ijpharm.2019.118626, LillOA]

Liste complète (Le lien peut être lent)

Communications

  1. L.-V. Roca Paixao, F. Ngono Mebenga, J.-F. willart, G.J. Cuello, M. Jimenez-Ruiz, N. T. Correia, F. Affouard, Manipulation of the crystalline and amorphous physical states of pharmaceutical materials: possibilities, limits and challenges, Conférence invitée, 32nd European Crystallographic Meeting (ECM32), Vienna, Autriche, Aou 2019 [LillOA]
  2. F. Tamani, C. Bassand, M.H.-B. Yelles, J.-F. willart, F. Danede, F. Siepmann, J. Siepmann, How single PLGA microparticles behave, Poster, 3rd European Conference on Pharmaceutics, Bologne, Italie, Mar 2018 [LillOA]
  3. M.-J. Garcia Fernandez, N. Tabary, F. Chai, J.-F. willart, N. Blanchemain, M.-P. Leterme Flament, B. Martel, Cyclodextrin polymer as a multifunctional excipient in tablet formulations, Poster, 19th International Cyclodextrin Symposium (ICS 2018)., Tokyo, Japon, Avr 2018 [LillOA]
  4. T. Rongthong, M. Gehrke, P. Oliveira, F. Danede, J.-F. willart, C. Vincent, F. Siepmann, J. Siepmann, Silicone matrices for controlled drug delivery to the inner ear: Effects of the drug form and agglomerates, Poster, 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical technology, Granada, Espagne, Mar 2018 [LillOA]
  5. M.-J. Garcia Fernandez, N. Tabary, J.-F. willart, F. Chai, N. Blanchemain, M.-P. Leterme Flament, B. Martel, 2.Multifunctional pharmaceutical excipient in tablet formulation based on citric acid-cyclodextrin polymer, Poster, 5th European Cyclodextrin Conference (EUROCD 2017), Lisbonne, Portugal, Oct 2017 [LillOA]
  6. M. Gehrke, T. Rongthong, G. Tourrel, D. Gnansia, P. Oliveira, J.-F. willart, L. Paccou, Y. Guinet, A. Hedoux, C. Vincent, F. Siepmann, J. Siepmann, Homogeneity, drug release and swelling of dexamethasone loaded cochlear implants, Poster, 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical technology, Granada, Espagne, Mar 2018 [LillOA]
  7. M.-J. Garcia Fernandez, N. Tabary, J.-F. willart, F. Chai, N. Blanchemain, M.-P. Leterme Flament, B. Martel, New pharmaceutical excipient based on polymers of cyclodextrins, Poster, 18ème Journées de la société française des cyclodextrines, Lens, France, Nov 2017 [LillOA]
  8. M. Latreche, J.-F. willart, A. Hedoux, Efficient solid state transformation protocol to determine the solubility of drugs into polymers, Communication dans un congrès sans actes, The 1st International Conference on Contemporary Pharmacy Challenges, Wisla, Pologne, Sep 2018 [LillOA]
  9. A. Krupa, M. Descamps, J.-F. willart, F. Danede, E. Wyska, R. Jachowicz, The technological solutions to enhance the bioavailability of tadalafil, Communication dans un congrès sans actes, The 1st International Conference on Contemporary Pharmacy Challenges, Wisla, Pologne, Sep 2018 [LillOA]
  10. F. Ngono Mebenga, F. Affouard, J.-F. willart, G. Cuello, M. Jimenez-Ruiz, Impact of the amorphisation routes on physical properties of amorphous materials, Communication dans un congrès sans actes, Journées de la Matière Condensée (JMC 2018), Grenoble, France, Aou 2018 [LillOA]

Liste complète (Le lien peut être lent)

 
 
UMET - Unité Matériaux et Transformations
CNRS UMR 8207
Université de Lille
Bâtiment C6
59655 Villeneuve d'Ascq
France
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