Alain HEDOUX

Professeur Université de Lille, IUT

Bâtiment P5 - 253
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33 (0)3 20 43 46 77
Fax: +33 (0)3 20 43 40 84
Courriel : Envoyer un mel à Alain HEDOUX
Identifiant ORCID : 0000-0002-8244-3512

Equipe: Matériaux moléculaires et thérapeutiques

Recherche

Analyse de l’organisation structurale et de la dynamique des matériaux moléculaires formateurs de verre dans leurs états amorphes et cristallins, des mécanismes de transformation de phases, et de stabilisation d’états amorphes de matériaux d’intérêt thérapeutique (petites molécules, protéines) par des excipients. Analyses par spectroscopie Raman, diffusion des neutrons, RX, calorimétrie.

Enseignement

IUT A – département Mesures Physique : Mécanique du point, du solide indéformable, déformable (élasticité) Master : Organisation structurale des états condensés de la matière.

Thèses en cours

• Basma MOUTAMENNI, . Thèse débutée en 2020. Co-direction: Nicolas TABARY.

Thèses soutenues

• Benjamin MALFAIT, Amélioration de la stabilité et de la biodisponibilité de matériaux pharmaceutiques et de biopharmaceutiques par confinement dans des systèmes à libération controlée . Thèse soutenue en 2019. Co-direction: Natalia CORREIA TEIXERA. Devenir post-thèse: Material Scientist | Solid-state expertise on small organic molecules.
• Tatiana STARCIUC, Stabilisation de matériaux biomoléculaires pour applications pharmaceutiques. Thèse soutenue en 2017. Devenir post-thèse: Docorante puis ATER à l'UMETCDI chez Astrazeneca.
• Sarah Nasser, Évolution des propriétés structurales et fonctionnelles des poudres de PhosPho Caséinate Native (PPCN) en lien avec l’état initial et les conditions de vieillissement. Thèse soutenue en 2017. Co-direction: Guillaume DELAPLACE. Devenir post-thèse: Specialiste de recherche chez Ingredia Dairy Experts.
• Samira Achir, Etude des mécanismes de stabilisation des protéines par spectroscopie Raman et dynamique moléculaire . Thèse soutenue en 2014. Co-direction: Frédéric AFFOUARD. Devenir post-thèse: Enseignante/Formatrice chez Université européenne des métiers de la finition CFA Gestes Formation.
• Adrien Lerbret, Étude de l'action bioprotectrice des sucres : une investigation par dynamique moléculaire et spectroscopie Raman. Thèse soutenue en 2005. Co-direction: Frédéric AFFOUARD, Marc DESCAMPS. Devenir post-thèse: Ingénieur de Recherche - Université de Bourgogne-AgroSup Dijon.
• Thomas Denicourt, Etude spectroscopique de systèmes désordonnés profondément sous-refroidis . Thèse soutenue en 2002. Co-direction: Marc DESCAMPS. Devenir post-thèse: Responsable informatique.

Derniers dépôts dans dans LillOA (Lille Open Archive)

Publications

21. Y. Guinet, L. Paccou, A. Hedoux, Analysis of Co-Crystallization Mechanism of Theophylline and Citric Acid from Raman Investigations in Pseudo Polymorphic Forms Obtained by Different Synthesis Methods, Molecules 28;4, 1605 (2023), [doi: 10.3390/molecules28041605, LillOA]
20. Y. Guinet, L. Paccou, A. Hedoux, Mechanism for Stabilizing an Amorphous Drug Using Amino Acids within Co-Amorphous Blends, Pharmaceutics 15;2, 337 (2023), [doi: 10.3390/pharmaceutics15020337, LillOA]
19. B. Moutamenni, N. Tabary, A. Mussi, J. Dhainaut, C. Ciotonea, A. Fadel, L. Paccou, Y. Guinet, A. Hedoux, Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery, Pharmaceutics 15;2, 390 (2023), [doi: 10.3390/pharmaceutics15020390, LillOA]
18. Y. Guinet, L. Paccou, F. Danede, P. Derollez, A. Hedoux, Identification of incommensurability in L-leucine: can lattice instabilities be considered as general phenomena in hydrophobic amino acids?, Physical Chemistry Chemical Physics 24, 27023-27030 (2022), [doi: 10.1039/d2cp00989g, LillOA]
17. K. Wu, S. Feng, A. Hedoux, E. Shalaev, Water structure in glycerol: Spectroscopic and computer simulation investigation of hydrogen bonding and water clustering, Journal of Molecular Liquids 355, 118916 (2022), [doi: 10.1016/j.molliq.2022.118916, LillOA]
16. Y. Guinet, L. Paccou, F. Danede, A. Hedoux, Revisiting the phase transition sequence in L-methionine: Description of the disordering mechanism in an essential amino acid, Journal of Chemical Physics 156;3, 034501 (2022), [doi: 10.1063/5.0077743, LillOA]
15. B. Moutamenni, N. Tabary, L. Paccou, Y. Guinet, A. Hedoux, MAL: High performance method for loading hydrophobic molecular materials into MCM-41 mesoporous silica – Analysis of confined L-tryptophan by Raman spectroscopy, Journal of Molecular Structure 1254, 132383 (2022), [doi: 10.1016/j.molstruc.2022.132383, LillOA]
14. T. Starciuc, Y. Guinet, A. Hedoux, E. Shalaev, Water content thresholds in glycerol/water system: Low- and high-wavenumber Raman spectroscopy study, Journal of Molecular Liquids 321, 114678 (2021), [doi: 10.1016/j.molliq.2020.114678, LillOA]
13. N. Schaeffer, D.O. Abranches, L.P. Silva, M.A. Martins, P.J. Carvalho, O. Russina, A. Triolo, L. Paccou, Y. Guinet, A. Hedoux, J.A. Coutinho, Non-Ideality in Thymol + Menthol Type V Deep Eutectic Solvents, ACS Sustainable Chemistry & Engineering 9;5, 2203-2211 (2021), [doi: 10.1021/acssuschemeng.0c07874, LillOA]
12. Y. Guinet, L. Paccou, F. Danede, A. Hedoux, Confinement of molecular materials using a solid-state loading method: a route for exploring new physical states and their subsequent transformation highlighted by caffeine confined to SBA-15 pores, RSC Advances 11;55, 34564-34571 (2021), [doi: 10.1039/D1RA05757J, LillOA]
11. B. Malfait, L. Paccou, N. T. Correia, Y. Guinet, A. Hedoux, Identification of an amorphous-amorphous two-step transformation in indomethacin embedded within mesoporous silica, Microporous and Mesoporous Materials 328, 111502 (2021), [doi: 10.1016/j.micromeso.2021.111502, LillOA]
10. M. Guerain, Y. Guinet, N. T. Correia, L. Paccou, F. Danede, A. Hedoux, Polymorphism and stability of ibuprofen/nicotinamide cocrystal: The effect of the crystalline synthesis method, International Journal of Pharmaceutics 584, 119454 (2020), [doi: 10.1016/j.ijpharm.2020.119454, LillOA]
9. Y. Guinet, L. Paccou, A. Hedoux, A detailed description of the devitrification mechanism of D-mannitol, Physical Chemistry Chemical Physics 22, 5011-5017 (2020), [doi: 10.1039/c9cp05287a, LillOA]
8. Y. Guinet, L. Paccou, A. Hedoux, Analysis of xylitol – citric acid system forming deep eutectic solvent: Application for dissolving poorly water-soluble drugs. A combination of calorimetric and Raman investigations, Journal of Molecular Liquids 318, 114317 (2020), [doi: 10.1016/j.molliq.2020.114317, LillOA]
7. B. Malfait, N. T. Correia, C. Ciotonea, J. Dhainaut, J.-P. Dacquin, s. royer, N. Tabary, Y. Guinet, A. Hedoux, Manipulating the physical states of confined ibuprofen in SBA-15 based drug delivery systems obtained by solid-state loading: Impact of the loading degree, The Journal of Chemical Physics 153;15, 154506 (2020), [doi: 10.1063/5.0020992, LillOA]
6. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, F. Danede, A. Hedoux, Contribution of low-frequency Raman spectroscopy to determine the solubility curves of drugs in polymers: The case of paracetamol/PVP, European Journal of Pharmaceutics and Biopharmaceutics 154, 222-227 (2020), [doi: 10.1016/j.ejpb.2020.07.012, LillOA]
5. A. Dupont, M. Guerain, F. Danede, L. Paccou, Y. Guinet, A. Hedoux, J.-F. willart, Kinetics and mechanism of polymorphic transformation of sorbitol under mechanical milling, International Journal of Pharmaceutics 590, 119902 (2020), [doi: 10.1016/j.ijpharm.2020.119902, LillOA]
4. J.F. Willart, A. Hedoux, Y. Guinet, F. Danede, L. Paccou, F. Capet, M. Descamps, Metastability release of the form alpha of trehalose by isothermal solid state vitrification, J. Phys. Chem. B 110, 11040-11043 (2019), [doi: 10.1021/jp061784r, LillOA]
3. T. Starciuc, B. Malfait, F. Danede, L. Paccou, Y. Guinet, N. T. Correia, A. Hedoux, Trehalose or sucrose; which of the two should be used for stabilizing proteins in the solid state? A dilemma investigated by in-situ micro-Raman and dielectric relaxation spectroscopies during and after freeze-drying, Journal of Pharmaceutical Sciences 109;1, 496-504 (2019), [doi: 10.1016/j.xphs.2019.10.055, LillOA]
2. M. Latreche, J.-F. willart, M. Guerain, A. Hedoux, F. Danede, Using Milling to Explore Physical States: The Amorphous and Polymorphic Forms of Sulindac, Journal of Pharmaceutical Sciences 108;8, 2635-2642 (2019), [doi: 10.1016/j.xphs.2019.03.017, LillOA]
1. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, A. Hedoux, Polymorphism versus devitrification mechanism: Low-wavenumber Raman investigations in sulindac, International Journal of Pharmaceutics 567, 118476 (2019), [doi: 10.1016/j.ijpharm.2019.118476, LillOA]

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Communications

10. M. Guerain, P. Derollez, C. Dejoie, N. T. Correia, F. Danede, F. Affouard, L. Paccou, Y. Guinet, A. Hedoux, C. Dejoie, Analyse structurale de matériaux moléculaires thérapeutiques cocristallisés par diffraction des rayons X, Communication dans un congrès sans actes, Rayons X et Matière 2019, Nancy, France, Nov 2019 [LillOA]
9. M. Gehrke, T. Rongthong, G. Tourrel, D. Gnansia, P. Oliveira, J.-F. willart, L. Paccou, Y. Guinet, A. Hedoux, C. Vincent, F. Siepmann, J. Siepmann, Homogeneity, drug release and swelling of dexamethasone loaded cochlear implants, Poster, 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical technology, Granada, Espagne, Mar 2018 [LillOA]
8. M. Latreche, J.-F. willart, A. Hedoux, Efficient solid state transformation protocol to determine the solubility of drugs into polymers, Communication dans un congrès sans actes, The 1st International Conference on Contemporary Pharmacy Challenges, Wisla, Pologne, Sep 2018 [LillOA]
7. S. Nasser, A. Giuliani, I. Dewaele, A. Hedoux, G. Delaplace, Evolution of secondary structure of milk powder during storage : Multivariate analysis FTIR and Circular Dichroism, International, Communication dans un congrès avec actes, Conference on Food Chemistry and Hydrocolloids, Canada, Sep 2016 [LillOA]
6. B. Malfait, N. T. Correia, A. Mussi, L. Paccou, Y. Guinet, A. Hedoux, Solid-state loading of pharmaceutical materials within mesoporous silica matrices, Communication dans un congrès sans actes, 1st International Conference on Contemporary Pharmacy Challenges: 1st International Conference on Contemporary Pharmacy Challenges:, Wisla, Pologne, Sep 2018 [LillOA]
5. T. Starciuc, L. Paccou, Y. Guinet, A. Hedoux, Mechanism of protein stabilization analyzed from in-situ Raman investigations during freeze-drying procedures, Conférence invitée, Freeze-drying of pharmaceuticals & biologicals, Garmisch-Partenkirchen, Allemagne, Sep 2018 [LillOA]
4. T. Starciuc, A. Hedoux, Y. Guinet, L. Paccou, Mechanisms of protein denaturation and stabilization analyzed in-situ during the freeze-drying process by micro-Raman spectroscopy, Conférence invitée, 8th International Discussion Meeting on Relaxations in Complex Systems (8IDMRCS), Wisla, Pologne, Juil 2017 [LillOA]
3. B. Malfait, N. T. Correia, A. Mussi, Y. Guinet, A. Hedoux, Confinement of APIs inside porous silicate matrices by milling: analysis of the physical state and stability of confined APIs, Poster, 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical technology, Grenade, Espagne, Mar 2018 [LillOA]
2. J. Junthip, N. Tabary, B. Martel, N. Blanchemain, F. Chai, M. Maton, C. Neut, A. Hedoux, D. Landy, Multilayer assembly of oppositely charged cyclodextrin polymers on textile for controlled drug delivery, Communication dans un congrès sans actes, Pure and Applied Chemistry International Conference (PACCON), Bangkok, Thaïlande, Fév 2016 [LillOA]
1. J. Junthip, N. Tabary, B. Martel, N. Blanchemain, F. Chai, A. Hedoux, D. Landy, L. Leclercq, Dual cyclodextrin polyelectrolyte multilayer coatings on textile for controlled drug delivery, Communication dans un congrès sans actes, EuroCD2015, Lille, France, Oct 2015 [LillOA]

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