Bernard MARTEL

Professor

Bâtiment C6, Bureau 119
Unité Matériaux et Transformations
Cité scientifique, Bât. C6
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: 03 20 43 46 35
Fax: +33 (0) 320 43 65 91
Email : Send an email to Bernard MARTEL
ORCID Identifier : 0000-0001-5329-3028

Research team: Ingénierie des systèmes polymères

Research

Functional polymeric systems applied to biomaterials for the release of therapeutic agents

Current PhD thesis

• Camille DUCHEMIN, Caractérisation physico-chimique, biomécanique et biologique d'un implant textile viscéral biorésorbable fonctionnalisé pour le renfort de la paroi abdominale en intention de traiter la hernie viscérale . Thesis started in 2023. Other co-advisor: BLANCHEMAIN Nicolas.
• Kim VANDEN BROECK, Conception et fonctionnalisation d'une endoprothèse fenêtrée pour apporter des propriétés antibactériennes et/ou antithrombotiques . Thesis started in 2023. Other co-advisor: BLANCHEMAIN Nicolas.
• HAMIDI Salim, Visco supplémentation antalgique intra articulaire pour la chirurgie maxillo faciale à base d'hydrogel de CHT et PcD . Thesis started in 2021. Other co-advisor: BLANCHEMAIN Nicolas.

Defended PhD thesis

• CHIJCHEAPAZA-FLORES Henry, Mise au point d'un hydrogel injectable pour le traitement des dysfonctionnements de l'articulation temporomandibulaire. Thesis defended in 2024. Other co-advisor: GARCIA FERNANDEZ Marie José.
• Marie Stella M BENGUE, Conception and evaluation of fenestred endoprothesis by 3D printig . Thesis defended in 2022.
• Dyhia KERSANI, Recouvrement de stent vasculaire par electrospinning pour la prévention de la restérose et de la thrombose . Thesis defended in 2019. Other co-advisor: Stéphanie DEGOUTIN. Position: Soutenance en décembre 2019.
• Syrine DIMASSI, Antithrombotic or osteoinductive bioactive membranes developed by electrospinning. Thesis defended in 2018. Other co-advisor: Nicolas TABARY.
• Safa Ouerghemmi, Electrospinning of antibacterial and anti-thrombotic chitosan based nanofibrous web. Thesis defended in 2016. Other co-advisors: Stéphanie DEGOUTIN, Nicolas TABARY. Position: Ingénieur R&D chez Cousin Biotech.
• Jatupol Junthip, Cyclodextrin polyelectrolytes multilayer coatings on textiles for the release of actives. Thesis defended in 2015. Other co-advisor: Nicolas TABARY. Position: Lecturer, Nakhon Ratchasima Rajabhat University, Thailand.
• Camille Saffre, Eco-design of ion-exchange textiles functionalized with bio-sourced polymers to decontaminate metals in dredged sediments. Thesis defended in 2015. Other co-advisors: Maryse BACQUET, Stéphanie DEGOUTIN. Position: Chargée de veille et intelligence économique chez Matikem  .
• Adeline Martin, Multilayered textile coating for drug delivery application. Thesis defended in 2013. Other co-advisor: Nicolas TABARY. Position: Chargée de Mission Santé Innovation - Croissance.
• Guillaume Vermet, Contribution of new antibacterial and analgesic properties on a implant for parietal refection. Thesis defended in 2012. Other co-advisor: Stéphanie DEGOUTIN. Position: Product Development Project Manager.
• Imen Kacem, Textiles with biological activity via the grafting by cold plasma and the immobilization of bioactive molecules. Thesis defended in 2012. Other co-advisors: Maude JIMENEZ, Roudesli Sadok . Position: Maître de conférences en Tunisie.
• Hélène Dhordain, Functionalization of nowoven structure by cyclodextrin for the working-out of a biocidal textile filter. Thesis defended in 2011. Position: Responsable R&D et Laboratoire chez Galloo Plastics SA.
• Tabary Nicolas, Functionalisation of biodegradable cellulose supports for the prolonged release of antibacterial agents for periodontological applications. Thesis defended in 2009. Other co-advisor: Blanchemain Nicolas.
• Laurent Thomas, Bloodproofing, antiseptic treatment and dyeing of a vascular prosthesis finished with cyclodextrin. Thesis defended in 2008. Other co-advisor: Hildebrand H.F..
• Lepretre Stéphane, Functionalisation of porous hydroxyapatite for the sustained delivery of antibiotics. Thesis defended in 2008. Other co-advisors: Blanchemain Nicolas, Hildebrand H.F..
• El Ghoul Yassine, Textile finishing with cyclodextrins of PP and PA supports- Application to dyeing and as antibiotic controlled release biomaterial. Thesis defended in 2007. Other co-advisor: Roudesli Sadok .
• Boschin François, Membrane functionalization for tissular controlled regeneration by controlled release of chlorhexidine in parodontology. Thesis defended in 2006. Other co-advisors: Hildebrand H.F., Delcourt-Debruyne E..
• Ducoroy Laurent, Modification of texilte fibers for the preparation of ion exchange texiles-Application to metallic decontamination of waste waters. Thesis defended in 2006. Other co-advisor: Maryse BACQUET.
• Nicolas Blanchemain, Study of the biocompatibility and of the grafting reaction of cyclodextrins onto PET vascular prostheses for the realization of a drug release device. Thesis defended in 2005. Position: Inserm U1008 "Médicaments et Biomatériaux à Libération Contrôlée", Faculté de Pharmacie, Université Lille 2.
• Ruffin Delphine , Polymerization and grafting of cyclodextrins onto textile fibers by crosslinking with polycarboxylic acids. Study of the process, and applications. Thesis defended in 2002. Other co-advisor: Michel Morcellet.
• Philippe Le Thuaut, Functionalisation of textile supports for the elaboration of filters for the adsorption of organic pollutants. Thesis defended in 2000. Other co-advisor: Michel Morcellet.

Latest scientific contributions in LillOA (Lille Open Archive)

Publications

21. M. Saab, C. Zobrist, N. Blanchemain, B. Martel, F. Chai, Systematic literature review of in vivo rat femoral defect models using biomaterials to improve the induced membrane technique: a comprehensive analysis, EFORT Open Reviews 9;2, 138-145 (2024), [doi: 10.1530/eor-23-0055, LillOA]
20. M. Maton, S. Gabut, C. Neut, P. Odou, C. Sacareau, A. Pinon, M. Vialette, G. Gerber, B. Martel, N. Blanchemain, Antiviral Functionalization of a Polypropylene Nonwoven as Self Decontaminating Layer for Respiratory Masks, Biomaterials Science (2023), [doi: 10.1039/d2bm01988d, LillOA]
19. H. Chijcheapaza-Flores, N. Tabary, F. Chai, M. Maton, J.-N. Staelens, F. Cazaux, C. Neut, B. Martel, N. Blanchemain, M.J. Garcia Fernandez, Injectable Chitosan-Based Hydrogels for Trans-Cinnamaldehyde Delivery in the Treatment of Diabetic Foot Ulcer Infections, Gels 9;3, 262 (2023), [doi: 10.3390/gels9030262, LillOA]
18. M.-S. M'bengue, T. Mesnard, F. Chai, M. Maton, V. Gaucher, N. Tabary, M.J. Garcia Fernandez, J. Sobocinski, B. Martel, N. Blanchemain, Evaluation of a Medical Grade Thermoplastic Polyurethane for the Manufacture of an Implantable Medical Device: The Impact of FDM 3D-Printing and Gamma Sterilization, Pharmaceutics 15;2, 456 (2023), [doi: 10.3390/pharmaceutics15020456, LillOA]
17. N.O. Muniz, S. Gabut, M. Maton, P. Odou, M. Vialette, A. Pinon, C. Neut, N. Tabary, N. Blanchemain, B. Martel, S. Gabut, Electrospun Filtering Membrane Designed as Component of Self-Decontaminating Protective Masks, Nanomaterials 13;1, 9 (2023), [doi: 10.3390/nano13010009, LillOA]
16. C. Mongioví, G. Crini, X. Gabrion, V. Placet, V. Blondeau-Patissier, A. Krystianiak, S. Durand, J. Beaugrand, A. Dorlando, C. Rivard, L. Gautier, A.R.L. Ribeiro, D. Lacalamita, B. Martel, J.-N. STAELENS, A. Ivanovska, M. Kostić, O. Heintz, C. Bradu, M. Raschetti, N. Morin-Crini, Revealing the adsorption mechanism of copper on hemp-based materials through EDX, nano-CT, XPS, FTIR, Raman, and XANES characterization techniques, Chemical Engineering Journal Advances 10, 100282 (2022), [doi: 10.1016/j.ceja.2022.100282, LillOA]
15. C. Mongioví, D. Lacalamita, N. Morin-Crini, X. Gabrion, V. Placet, A.R.L. Ribeiro, A. Ivanovska, M. Kostić, C. Bradu, J.-N. STAELENS, B. Martel, M. Raschetti, G. Crini, Use of chènevotte, a valuable co-product of industrial hemp fiber, as adsorbent for copper ions: Kinetic studies and modeling, Arabian Journal of Chemistry 15;4, 103742 (2022), [doi: 10.1016/j.arabjc.2022.103742, LillOA]
14. M. Diop, O. Thioune, C. Neut, M. Maton, C. Riviere, B. Martel, S. Mahieux, V. Roumy, N. Blanchemain, In vitro evaluation of antibacterial activity of a plant extract-loaded wound dressing, Journal of Drug Delivery Science and Technology 67, (2022), [doi: 10.1016/j.jddst.2021.102950, LillOA]
13. S. Ouerghemmi, S. Degoutin, M. Maton, N. Tabary, F. Cazaux, C. Neut, N. Blanchemain, B. Martel, Core-Sheath Electrospun Nanofibers Based on Chitosan and Cyclodextrin Polymer for the Prolonged Release of Triclosan., Polymers (Basel) 14;10, 1955 (2022), [doi: 10.3390/polym14101955, LillOA]
12. C. Godeau, N. Morin-Crini, J.-N. STAELENS, B. Martel, S. Rocchi, G. Chanet, M. Fourmentin, G. Crini, Adsorption of a triazole antifungal agent, difenoconazole, on soils from a cereal farm: Protective effect of hemp felt, Environmental Technology & Innovation 101394 (2021), [doi: 10.1016/j.eti.2021.101394, LillOA]
11. G. Crini, C. Bradu, C. Cosentino, J.-N. STAELENS, B. Martel, S. Loiacono, G. Chanet, G. Torri, N. Morin-Crini, Simultaneous Removal of Inorganic and Organic Pollutants from Polycontaminated Wastewaters on Modified Hemp-Based Felts, Revista de Chimie 72;1, 25-43 (2021), [doi: 10.37358/rc.21.1.8401, LillOA]
10. K. Sy, K. Agossa, M. Maton, H. Chijcheapaza-Flores, B. Martel, F. Siepmann, E. Deveaux, N. Blanchemain, C. Neut, How Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium Hydroxide Paste as an Intracanal Medication: An In Vitro Study., Antibiotics (Basel) 10;11, 1352 (2021), [doi: 10.3390/antibiotics10111352, LillOA]
9. B. Martel, C. Campagne, N. Massika Behary, When textiles help your recovery, Médecine/Sciences 33, 73-80 (2019), [doi: 10.1051/medsci/20173301012, LillOA]
8. N. Morin‐Crini, J.-N. STAELENS, S. Loiacono, B. Martel, G. Chanet, G. Crini, Simultaneous removal of Cd, Co, Cu, Mn, Ni, and Zn from synthetic solutions on a hemp‐based felt. III. Real discharge waters, Journal of Applied Polymer Science 137;24, 48823 (2019), [doi: 10.1002/app.48823, LillOA]
7. Y. El Ghoul, N. Blanchemain, T. Laurent, C. Campagne, A. El Achari, S. Roudesli, M. Morcellet, B. Martel, F. Chai, Chemical, biological and microbiological evaluation of cyclodextrin finished polyamide inguinal meshes, Acta Biomaterialia 4, 1392-1400 (2015), [doi: 10.1016/j.actbio.2008.02.019, LillOA]
6. E. Jean-Baptiste, N. Blanchemain, B. Martel, C. Neut, H.F. Hildebrand, S. Haulon, Safety, Healing, and Efficacy of Vascular Prostheses Coated with Hydroxypropyl-beta-cyclodextrin Polymer: Experimental In Vitro and Animal Studies, Eur. J. Vasc. Endovasc. Surg. 43, 188-197 (2015), [doi: 10.1016/j.ejvs.2011.10.017, LillOA]
5. I. Kacem, T. Laurent, N. Blanchemain, C. Neut, F. Chai, S. Haulon, H.F. Hildebrand, B. Martel, Dyeing and antibacterial activation with methylene blue of a cyclodextrin modified polyester vascular graft, J. Biomed. Mater. Res. Part A 102, 2942-2951 (2015), [doi: 10.1002/jbm.a.34965, LillOA]
4. E. Jean-Baptiste, N. Blanchemain, C. Neut, F. Chai, M. Maton, B. Martel, H. Hildebrand, S. Haulon, Evaluation of the anti-infectious properties of polyester vascular prostheses functionalised with cyclodextrin, J. Infect. 68, 116-124 (2015), [doi: 10.1016/j.jinf.2013.10.002, LillOA]
3. J. Sobocinski, W. Laure, M. Taha, E. Courcot, F. Chai, N. Simon, A. Addad, B. Martel, S. Haulon, P. Woisel, N. Blanchemain, J. Lyskawa, Mussel Inspired Coating of a Biocompatible Cyclodextrin Based Polymer onto CoCr Vascular Stents, ACS Appl. Mater. Interfaces 6, 3575-3586 (2015), [doi: 10.1021/am405774v, LillOA]
2. M. Taha, F. Chai, N. Blanchemain, C. Neut, M. Goube, M. Maton, B. Martel, H.F. Hildebrand, Evaluation of sorption capacity of antibiotics and antibacterial properties of a cyclodextrin-polymer functionalized hydroxyapatite-coated titanium hip prosthesis, Int. J. Pharm. 477, 380-389 (2015), [doi: 10.1016/j.ijpharm.2014.10.026, LillOA]
1. N. Scoutaris, F. Chai, B. Maurel, J. Sobocinski, M. Zhao, J.G. Moffat, D.Q. Craig, B. Martel, N. Blanchemain, D. Douroumis, Development and Biological Evaluation of Inkjet Printed Drug Coatings on Intravascular Stent, Mol. Pharm. 13, 125-133 (2015), [LillOA]

Full list (The link could be slow)

Conference presentations

10. D. Kersani, J. Mougin, M. Lopez, S. Degoutin, N. Tabary, F. Cazaux, B. Hue, L. Janus, M. Maton, F. Chai, J. Sobocinski, N. Blanchemain, B. Martel, Stent vasculaire recouvert de nanofibres fonctionnelles pour la prévention de la thrombose et de la resténose : élaboration, caractérisation et évaluation préclinique, Communication dans un congrès sans actes, GDR Réparer l'Humain, Strasbourg (100% virtuel), France, Sep 2020 [LillOA]
9. D. Kersani, J. Mougin, M. Lopez, S. Degoutin, N. Tabary, F. Cazaux, B. Hue, L. Janus, M. Maton, F. Chai, J. Sobocinski, N. Blanchemain, B. Martel, Nanofiber-coated vascular stent for the prevention of thrombosis and restenosis: conception, characterization and preclinical evaluation, Communication dans un congrès sans actes, MEDFIT, Lille, France, Dec 2020 [LillOA]
8. S. Ouerghemmi, S. Degoutin, N. Tabary, F. Cazaux, L. Janus, F. Chai, N. Blanchemain, B. Martel, Electrospinning of a disulfonated chitosan as an artificial GAG for tissue engineering, Communication dans un congrès sans actes, 10th World Biomaterials Congress, Montréal, Canada, May 2016 [LillOA]
7. D. Kersani, M. Lopez, J. Mougin, S. Degoutin, N. Tabary, F. Cazaux, B. Hue, M. Maton, F. Chai, J. Sobocinski, N. Blanchemain, B. Martel, Drug-eluting stents coated by simvastatin-loaded poly-cyclodextrin nanofibers: in vitro release study and in vivo preliminary evaluation, Communication dans un congrès sans actes, 19th International Cyclodextrin Symposium (ICS 19), Tokyo (Japan), Japon, Apr 2018 [LillOA]
6. C. Zobrist, F. Chai, S. Hamidi, M. Daoudi, S. Degoutin, N. Blanchemain, B. Martel, Enhanced osteointegration of the ligament through a tailored local osteoinductive product delivery, Poster, ESB2022 - the 32nd Annual Conference of the European Society for Biomaterials, Bordeaux, France, Sep 2022 [LillOA]
5. C. Zobrist, S. Hamidi, M. Dufay, M. Daoudi, F. Chai, S. Noël, N. Blanchemain, B. Martel, Amélioration de l’ostéointégration des ligaments artificiels par la libération localisée de composés ostéoinducteurs, Communication dans un congrès sans actes, Matériaux 2022, Lille, France, Oct 2022 [LillOA]
4. K. Belkhir, J. Potier, G. Le Fer, P. Woisel, B. Martel, N. Tabary, S. Degoutin, F. Cazaux, M. Maton, C. Palomino Durand, N. Blanchemain, Polymères Fonctionnels et Stimuli-Répondants pour la Délivrance de Médicaments et la Régénération Tissulaire, Communication dans un congrès avec actes, Groupe de Recherche National "Réparer l'Humain". 1ʳᵉ rencontre annuelle du GDR Réparer l'Humain « Matériaux et Procédés pour Applications Médicales », Paris, France, Dec 2023 [LillOA]
3. S. Fadlallah, B. Leger, S. Noel, F. Cazaux, N. Tabary, E. Monflier, B. Martel, Composite nanofibers containing ruthenium nanoparticles stabilized by cyclodextrin polymers: synthesis, characterization and their application in heterogeneous catalysis, Communication dans un congrès avec actes, 19èmes Journées Cyclodextrines, Besançon, France, Nov 2024 [LillOA]
2. D. Kersani, J. Mougin, M. Lopez, S. Degoutin, N. Tabary, F. Cazaux, L. Janus, B. Hue, M. Maton, F. Chai, J. Sobocinski, N. Blanchemain, B. Martel, Coating of vascular stents with simvastatin loaded nanofibers by electrospinning for the prevention of restenosis and thrombosis, Communication dans un congrès sans actes, ESB 2018, Maastricht, Pays-Bas, Sep 2018 [LillOA]
1. M. Lopez, D. Kersani, J. Mougin, N. Tabary, F. Cazaux, S. Degoutin, B. Hue, L. Janus, M. Maton, F. Chai, J. Sobocinski, N. Blanchemain, B. Martel, Electrospun polyvinyl alcohol – cyclodextrin nanofibers for biomedical applications, Communication dans un congrès sans actes, ESB 2018, Maastricht, Pays-Bas, Sep 2018 [LillOA]

Full list (The link could be slow)

Patents

4. 2024 N. Blanchemain, B. Martel, N. Tabary, M.J. Garcia Fernandez, M.-S. M'bengue, T. Mesnard, J. Sobocinski, F. Chai, Manufacture of an endoprosthesis by 3D printing, WO2024213841 (A1), FR2303720, publication 17 Oct 2024, enregistrement 13 Apr 2023 [LillOA]
3. 2018 N. Blanchemain, B. Martel, C. FLORES, F. Cazaux, F. Chai, N. Tabary, M. LOPEZ HEREDIA, PROCÉDÉ DE FABRICATION D'HYDROGEL À BASE DE CHITOSAN ET DE POLYÉLECTROLYTES CHARGÉS NÉGATIVEMENT ET MATÉRIAU POREUX ALVÉOLAIRE ISSU DUDIT HYDROGEL, FR3038318 (2017), O2017001808 (2017), CA2991000 (2017), CN107949598 (2018), JP2018519120 (2018), EP3317326 (2018), ES2854712 (2021), US11168183B2 (2021), FR1556283, publication 09 May 2018, enregistrement 01 Jul 2016 [LillOA]
2. 2024 N. Blanchemain, F. Chai, B. Martel, R. Nicot, M.J. Garcia Fernandez, N. Tabary, H. Chijcheapaza-Flores, Hydrogel composition for use in the treatment of articular disorders, WO 2024/023350A1, 22306135.9, publication 01 Feb 2024, enregistrement 28 Jul 2023 [LillOA]
1. 2019 B. Martel, N. Blanchemain, S. Degoutin, G. Vermet, Dispositif implantable comprenant une pièce textile comprenant des fils multifilamentaires et/ou des fils filés de fibres revetu(e)s en tout ou partie d’un polymère de cyclodextrine, FR3080539 (2019); WO2019207227 (2019); EP3784304 (2022); US2021052772 (2021), FR1853737, publication 31 Oct 2019, enregistrement 05 Apr 2019 [LillOA]

Patents (old list, before 2018)

10. 2017 - B. Martel, N. Blanchemain, M. P. Flament, J. F. Willart, N. Tabary, M. J. Garcia-Fernandez: Utilisation de fractions solubles, insolubles d'un polymère de cyclodextrine ou de leurs mélanges comme excipient dans un comprimé.
    Brevet français FR3040883 déposé le 14/09/2015 Numéro de publication internationale : WO2017/046506 A1
9. 2017 - N. Blanchemain, B. Martel, C. Flores, F. Cazaux, F. Chai, N. Tabary, M. Lopez: Procédé de fabrication d'hydrogel à base de chitosan et de polyélectrolytes chargés négativement et matériau poreux alvéolaire issu dudit hydrogel.
   Brevet français FR3038318 déposé le 02/07/2015 Numéro de publication internationale : WO2017/001808 A1
8. 2012 - B. Martel, Et Al: Dispositif implantable de réparation et de reconstruction osseuse apte à adsorber des agents bio-actifs et procédés de fabrication d’un tel dispositif.
   brevet français FR-12 52690 déposé le 26/03/2012
7. 2011 - B. Martel, Et Al: Dispositif de filtration d’un flux d’air a activite anti-bacterienne et/ou anti-virale et/ou anti-fongique et procede de preparation d’un tel dispositif.
   brevet français n° 11/61887 déposé le 19/12/2011
6. 2010 - B. Martel, N. Tabary, Et Al: Dispositif resorbable permettant la libération prolongée de chlorhexidine dans la poche parodontale.
   brevet n° 1058433 déposé le 15/10/2010
5. 2008 - T. Laurent, B. Martel, M. Morcellet, N. Blanchemain, H. F. Hildebrand: Prothèse vasculaire imperméable et procédé de préparation de ladite prothèse.
   WO 2009/095594
4. 2006 - S. Haulon, J. Mondot, H. F. Hildebrand, N. Blanchemain, B. Martel: Method for preparing an implantable prosthesis from a porous base body and associated prosthesis and use thereof .
   EP2086603 (A2), WO2007FR01822 ; FR20060009678 ; FR20070058629 JP2010508109 (A)
3. 2006 - B. Martel, N. Blanchemain, M. Morcellet, H. F. Hildebrand, S. Haulon, F. Boschin, E. Delcourt-Debruyne: Biomatériaux porteurs de cyclodextrines aux propriétés d’absorption améliorées et de libération progressive et retardée de molécules thérapeutiques.
   FR2 877 846 B1 PCT/FR2005/002829 WO 2006/051227 CN101080247A EP05817573.8 JPN : 2007-540685
2. 2006 - M. Weltrowski, M. Morcellet, B. Martel: Procédé de traitement d’une fibre ou d’un matériau à base de fibres en vue d’améliorer ses propriétés adsorbantes et fibre ou matériau à base de fibres présentant des propriétés adsorbantes améliorées..
   FR 9901967 (2000) DE 600 10 055 T2 (2005) EP 1,157,156 B1 (2004) US 7,048,769B1 (2006) CA 2,362,534 WO 0047811
1. 2003 - B. Martel, M. Morcellet, M. Weltrowski: Procédé de fabrication de polymères solubles et insolubles à base de cyclodextrine(s) et /ou de dérivés de cyclodextrine(s) et polymères solubles à base de cyclodextrine(s) et/ou de dérivés de cyclodextrine(s).
   FR 2 789 685 (2001) EP 1 165 621 B1 (2002) US 6,660,804 B1 (2003) WO 00/047630 (2000)