Marc DESCAMPS

Professor

Bâtiment P5 - 221
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33 (0)3 20 43 49 79
Fax: +33 (0)3 20 43 40 84
Email : Send an email to Marc DESCAMPS
ORCID Identifier :

Research team: Matériaux moléculaires et thérapeutiques

Research

Disordered molecular crystals: Glassy crystals, Kinetics of phase transformations, molecular mobility. Glass and glass transition. Physics of pharmaceutical solids. Driven molecular solids(Milling induced transformations)

Editing

• Book Disordered Pharmaceutical Materials (522 pages) Edited by Marc Descamps, May 2016 WILEY - VCH
• Special issue of Advanced Drug Delivery Reviews: Amorphous Pharmaceutical Solids (Theme editor: Marc Descamps) Volume 100, May 2016

Defended PhD thesis

• Anne-Amandine Decroix, Stabilité physique et désordre orientationnel dans un cristal à usage thérapeutique : la cafeine. Thesis defended in 2009. Other co-advisor: Laurent CARPENTIER. Position: Maître de conférences à l'Université d'Artois.
• Angeline Aumelas, Broyage de composés pharmaceutiques: changement d’état physique et manipulation de la stabilité. Thesis defended in 2008. Position: Ingénieur de recherche SNPE Matériaux Energétiques.
• Vincent Caron, Mecanosynthesis of molecular alloys. Thesis defended in 2006. Other co-advisor: Jean-François WILLART. Position: Post-doctorat à l'Université de Dublin.
• Adrien Lerbret, Study of the biopreservative capabilities of sugars: investigation from molecular dynamics and Raman spectroscopy. Thesis defended in 2005. Other co-advisors: Frédéric AFFOUARD, Alain HEDOUX. Position: Ingénieur de Recherche - Université de Bourgogne-AgroSup Dijon.
• Sylvain Desprez, Matériaux moléculaires forcés : recherche des forces motrices de transformation. Thesis defended in 2004. Position: Chercheur Materia Nova, Mons, Belgique.
• Armelle De Gusseme, Transformation athermique de matériaux pharmaceutiques. Thesis defended in 2003. Other co-advisor: Jean-François WILLART. Position: Principal scientist, laboratoire GSK.
• Thomas Denicourt, Etude spectroscopique de systèmes désordonnés profondément sous-refroidis . Thesis defended in 2002. Other co-advisor: Alain HEDOUX. Position: Responsable informatique.
• Marlène Tétaert, Dynamical Study of Plastic Molecular Crystals. Thesis defended in 2001. Other co-advisor: Jean-François WILLART.
• Olivier Bustin, Relaxation Structurale des matériaux vitrifiables par calorimétrie à balayage modulé. Thesis defended in 1999. Position: Responsable dans la banque.
• Valérie Legrand, Contribution à l'étude de la vitrification de liquides moléculaires fragiles. Thesis defended in 1996. Position: Ingénieur Recherche Société agro-alimentaire.
• Olivier Delcourt, Effet de taille et bistabilité thermodynamique dans le cyanoadamantane. Thesis defended in 1993. Position:  Responsable informatique laboratoire recherche Decathlon.
• Najib Benzakour, Phases stables et métastables d'un cristal vitreux. Thesis defended in 1992.
• Jean-François WILLART, Transformation de phase et brisure d'ergodicité dans un verre d'orientation. Thesis defended in 1991. Position: Chargé de recherches CNRS.
• Mohamed El Adib, Cinétique de transformation d'un cristal vitreux. Thesis defended in 1989.
• Claude Caucheteux, Etude par diffusion des rayons X de la cinétique d'évolution d'un verre d'orientation : le 1-cyanoadamantane, mécanisme de la transition vitreuse. Thesis defended in 1987. Position: Ingenieur Enraf Nonius.
• Patrick DEROLLEZ, Le succinonitrile: un cas de molécule déformable dans l'étude d'un cristal à désordre orientationnel. Thesis defended in 1984. Position: Retraite en 2023.

Latest scientific contributions in LillOA (Lille Open Archive)

Publications

21. J.-F. willart, S. Ouerghemmi, N. Descamps, P. Heijboer, L. Paccou, F. Danede, M. Descamps, The melting of glucose, International Journal of Pharmaceutics 626, 122185 (2022), [doi: 10.1016/j.ijpharm.2022.122185, LillOA]
20. P.F.M. Oliveira, J.-F. willart, J. Siepmann, F. Siepmann, M. Descamps, Using Milling To Explore Physical States: The Amorphous and Polymorphic Forms of Dexamethasone, Crystal Growth & Design 18, 1748-1757 (2018), [doi: 10.1021/acs.cgd.7b01664, LillOA]
19. M. Descamps, J.-F. willart, Scaling laws and size effects for amorphous crystallization kinetics: Constraints imposed by nucleation and growth specificities, International journal of pharmaceutics 542, 186-195 (2018), [doi: 10.1016/j.ijpharm.2018.03.001, LillOA]
18. A. Mahieu, J.-F. willart, M. Guerain, P. Derollez, F. Danede, M. Descamps, Structure determination of phase II of the antifungal drug griseofulvin by powder X-ray diffraction, Acta Crystallographica Section C Structural Chemistry 74, 321-324 (2018), [doi: 10.1107/S2053229618001845, LillOA]
17. E. Elisei, J.-F. willart, F. Danede, J. Siepmann, F. Siepmann, M. Descamps, Crystalline Polymorphism Emerging From a Milling-Induced Amorphous Form: The Case of Chlorhexidine Dihydrochloride, Journal of Pharmaceutical Sciences 107, 121-126 (2018), [doi: 10.1016/j.xphs.2017.07.003, LillOA]
16. J.-F. willart, E. Dudognon, A. Mahieu, M.D. Eddleston, W. Jones, M. Descamps, The role of cracks in the crystal nucleation process of amorphous griseofulvin, The European Physical Journal Special Topics 226, 837-847 (2017), [doi: 10.1140/epjst/e2016-60358-y, LillOA]
15. P. Martinetto, P. Bordet, M. Descamps, E. Dudognon, W. Pagnoux, J.-F. Willart, Structural Transformations of d -Mannitol Induced by in Situ Milling Using Real Time Powder Synchrotron Radiation Diffraction, Crystal Growth & Design 17, 6111-6122 (2017), [doi: 10.1021/acs.cgd.7b01283, LillOA]
14. A. Benazzouz, E. Dudognon, N. T. Correia, V. Molinier, J.-M. Aubry, M. Descamps, Interactions underpinning the plasticization of a polymer matrix: a dynamic and structural analysis of DMP-plasticized cellulose acetate, Cellulose 24, 487-503 (2017), [doi: 10.1007/s10570-016-1148-y, LillOA]
13. P. Bordet, A. Bytchkov, M. Descamps, E. Dudognon, E. Elkaïm, P. Martinetto, W. Pagnoux, A. Poulain, J.-F. willart, Solid State Amorphization of β-Trehalose: A Structural Investigation Using Synchrotron Powder Diffraction and PDF Analysis, Crystal Growth & Design 16, 4547-4558 (2016), [doi: 10.1021/acs.cgd.6b00660, LillOA]
12. M. Descamps, A. Aumelas, S. Desprez, J.-F. willart, The amorphous state of pharmaceuticals obtained or transformed by milling: Sub-Tg features and rejuvenation, Journal of Non-Crystalline Solids 407, 72-80 (2015), [doi: 10.1016/j.jnoncrysol.2014.08.055, LillOA]
11. E. Gué, S. Florin Muschert, J.-F. Willart, F. Danede, M. Descamps, E. Delcourt-Debruyne, J. Siepmann, Accelerated fenofibrate release from spray-dried microparticles based on polymer blends, Journal of Drug Delivery Science and Technology 24, 185-190 (2015), [doi: 10.1016/S1773-2247(14)50030-5, LillOA]
10. M. Descamps, E. Dudognon, Crystallization from the Amorphous State: Nucleation-Growth Decoupling, Polymorphism Interplay, and the Role of Interfaces, Journal of Pharmaceutical Sciences 103, 2615-2628 (2014), [doi: 10.1002/jps.24016, LillOA]
9. A. Mahieu, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, A new protocol to determine the solubility of drugs into polymer matrixes, Molecular Pharmaceutics 10, 560-566 (2013), [doi: 10.1021/mp3002254, LillOA]
8. A. Mahieu, J.-F. willart, E. Dudognon, M.D. Eddleston, W. Jones, F. Danede, M. Descamps, On the polymorphism of griseofulvin: Identification of two additional polymorphs, Journal of Pharmaceutical Sciences 102, 462-468 (2013), [doi: 10.1002/jps.23349, LillOA]
7. N. Dujardin, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, Mechanism of Solid State Amorphization of Glucose upon Milling, The Journal of Physical Chemistry B 117, 1437-1443 (2013), [doi: 10.1021/jp3069267, LillOA]
6. E. Dudognon, N. T. Correia, F. Danede, M. Descamps, Solid-Solid Transformation in Racemic Ibuprofen, Pharmaceutical Research 30, 81-89 (2013), [doi: 10.1007/s11095-012-0851-0, LillOA]
5. E. Gué, J.-F. Willart, S. Florin Muschert, F. Danede, E. Delcourt, M. Descamps, J. Siepmann, Accelerated ketoprofen release from polymeric matrices: Importance of the homogeneity/heterogeneity of excipient distribution, International journal of pharmaceutics 457, 298-307 (2013), [doi: 10.1016/j.ijpharm.2013.09.023, LillOA]
4. N. Tabary, A. Mahieu, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, m. Bacquet, B. Martel, Characterization of the hidden glass transition of amorphous cyclomaltoheptaose, Carbohydrate research 346, 2193-2199 (2011), [doi: 10.1016/j.carres.2011.07.010, LillOA]
3. N. Dujardin, E. Dudognon, J.-F. willart, A. Hedoux, Y. Guinet, L. Paccou, M. Descamps, Solid state mutarotation of glucose, J. Phys. Chem. B 115, 1698-1705 (2011), [doi: 10.1021/jp109382j, LillOA]
2. N. Dujardin, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, First obtaining of glass solutions and phase diagram of glucose with fully tunable anomeric concentration, Journal of Pharmaceutical Sciences 99, 1476 - 1483 (2010), [doi: 10.1002/jps.21900, LillOA]
1. J.-F. willart, N. Dujardin, E. Dudognon, F. Danede, M. Descamps, Amorphization of sugar hydrates upon milling, Carbohydrate research 345, 1613 (2010), [doi: 10.1016/j.carres.2010.04.014, LillOA]

Full list (The link could be slow)

Conference presentations

10. J.-F. Willart, S. Ouerghemmi, N. Descamps, P. Heijboer, M. Descamps, Mécanisme de liquéfaction du glucose, Poster, Conférence International Matériaux 2022, Lille, France, Nov 2024 [LillOA]
9. p. Bordet, P. Martinetto, J.-F. Willart, M. Descamps, E. Dudognon, In-situ powder diffraction study of molecular compounds under high energy milling: from amorphization to solid state transformation, Communication dans un congrès sans actes, EPDIC 16 (16th European Powder Diffraction Conference), Edinburgh, Scotland, Royaume-Uni, Nov 2024 [LillOA]
8. J.-F. Willart, p. Bordet, M. Descamps, E. Dudognon, P. Martinetto, W. Pagnoux, Kinetics of polymorphic transformations of pharmaceuticals induced by mechanical milling, Communication dans un congrès sans actes, ISMANAM 2018 (25th international Symposium on Metastable, Amorphous and Nanostructured Materials), Rome, Italie, Nov 2024 [LillOA]
7. p. Bordet, P. Martinetto, W. Pagnoux, J.-F. Willart, M. Descamps, E. Dudognon, Etude in-situ de composés moléculaires sous broyage à haute énergie: de l'amorphisation à la transformation à l'état solide, Communication dans un congrès sans actes, AFC 2018 (16th European Powder Diffraction Conference), Lyon, France, Nov 2024 [LillOA]
6. M. Descamps, J.-F. Willart, Size effects on amorphous crystallization kinetics: Constraints imposed by nucleation and growth specificities, Communication dans un congrès sans actes, JMC 2018, Jjournées de la Matière Condensée, Grenoble (27-31 août 2018), Grenoble, France, Nov 2024 [LillOA]
5. M. Descamps, J.-F. Willart, E. Dudognon, Milling As a Tool to Manipulate and Screen Amorphism and Polymorphism, Conférence invitée, 9th IDMRCS (9th International discussion meeting on relaxations in complex systems), Tsukuba, Japon, Nov 2024 [LillOA]
4. M. Descamps, J.-F. Willart, The Glass Transition of Glassy crystals: Structural Nature of Critical Slowdown & Aging, Conférence invitée, The Glass Transition of Glassy crystals: Structural Nature of Critical Slowdown & Aging, Chiba, Japon, Nov 2024 [LillOA]
3. E. Dudognon, A. Benazzouz, V. Molinier, J.-M. Aubry, M. Descamps, N. T. Correia, Dynamic and structural investigation of interactions at the origin of the plasticization of a polymer matrix: the case of DMP-plasticized Cellulose Acetate, Communication dans un congrès sans actes, 8th International Discussion Meeting on Relaxations in Complex Systems (8IDMRCS), Wisla, Pologne, Jul 2017 [LillOA]
2. A. Krupa, M. Descamps, J.-F. willart, F. Danede, E. Wyska, R. Jachowicz, The technological solutions to enhance the bioavailability of tadalafil, Communication dans un congrès sans actes, The 1st International Conference on Contemporary Pharmacy Challenges, Wisla, Pologne, Sep 2018 [LillOA]
1. M. Descamps, INTRODUCTION TO AMORPHOUS SYSTEMS Glass-forming ability and Stability, Conférence invitée, APV ASD Master Class - Abbvie, Ludwigshafen, Allemagne, Nov 2017 [LillOA]

Full list (The link could be slow)