Emeline DUDOGNON

Assistant professor

Bâtiment P5 - 213
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33 (0)3 20 43 69 90
Fax: +33 (0)3 20 43 40 84
Email : Send an email to Emeline DUDOGNON
ORCID Identifier : 0000-0003-4176-1925

Research team: Matériaux moléculaires et thérapeutiques

Research

* Crystalline/glassy state duality : phases transformations and low temperatures nucleation * Forced pharmaceutical materials: amorphisation, polymorphic transformations and obtaining by mecanosynthesis of out of equilibrium molecular alloys * Molecular mobility of glass forming liquids in the glass transition range

Teaching

Teaching at undergraduate level (fluids mecanic, electrokinetic,…)

Current PhD thesis

• Nina ZUPAN, Dispositifs pharmaceutiques à l'état solide contre l'aggravation du diabète . Thesis started in 2021.

Defended PhD thesis

• Simon SAMSOEN, Design et caractérisation physique de matrices polymères pour l’optimisation de la libération de principes actifs pharmaceutiques . Thesis defended in 2024. Other co-advisors: Frédéric AFFOUARD, Patrice WOISEL.
• Jeanne-Annick BAMA, Stabilité et mobilité des matériaux pharmaceutiques multi composants moléculaires . Thesis defended in 2021. Other co-advisor: Frédéric AFFOUARD.
• Aurélien Mahieu, New methods to determine polymer / drug solubility diagrams. Thesis defended in 2013. Other co-advisor: Jean-François WILLART. Position: CDI / Société ADOCIS "Rédacteur Technique Crédit Impôt Recherche (CIR)" à Angers.
• Nicolas Dujardin, Solid State Amorphization of Glucose and Control of the Mutarotation. Thesis defended in 2009. Other co-advisor: Jean-François WILLART.

Latest scientific contributions in LillOA (Lille Open Archive)

Publications

20. N. Zupan, I. Yous, F. Danede, J. Verin, M. Kouach, C. Foulon, E. Dudognon, S. Florin Muschert, Impact of Hot-Melt Extrusion on Glibenclamide's Physical and Chemical States and Dissolution Behavior: Case Studies with Three Polymer Blend Matrices., Pharmaceutics 16;8, 1071 (2024), [doi: 10.3390/pharmaceutics16081071, LillOA]
19. S. Samsoen, E. Dudognon, G. Le Fer, D. Fournier, P. Woisel, F. Affouard, Impact of the Polymer Dispersity on the Properties of Curcumin/Polyvinylpyrrolidone Amorphous Solid Dispersions, International Journal of Pharmaceutics 653, 123895 (2024), [doi: 10.1016/j.ijpharm.2024.123895, LillOA]
18. E. Dudognon, F. Danede, M. Guerain, Milling-induced Phase Transformations, Underlying Mechanisms and Resulting Physical States in an Enantiotropic System: the Case of Bezafibrate, Crystal Growth & Design 22;1, 363-378 (2022), [doi: 10.1021/acs.cgd.1c00997, LillOA]
17. J.A. Bama, E. Dudognon, F. Affouard, Impact of Low Concentration of Strongly Hydrogen-Bonded Water Molecules on the Dynamics of Amorphous Terfenadine: Insights from Molecular Dynamics Simulations and Dielectric Relaxation Spectroscopy, The Journal of Physical Chemistry B 125;40, p. 11292-11307 (2021), [doi: 10.1021/acs.jpcb.1c06087, LillOA]
16. E. Dudognon, F. Affouard, J.A. Bama, Molecular Mobility of Terfenadine: Investigation by Dielectric Relaxation Spectroscopy and Molecular Dynamics Simulation, Molecular Pharmaceutics 16;11, 4711-4724 (2019), [doi: 10.1021/acs.molpharmaceut.9b00877, LillOA]
15. J.-F. willart, E. Dudognon, A. Mahieu, M.D. Eddleston, W. Jones, M. Descamps, The role of cracks in the crystal nucleation process of amorphous griseofulvin, The European Physical Journal Special Topics 226, 837-847 (2017), [doi: 10.1140/epjst/e2016-60358-y, LillOA]
14. P. Martinetto, P. Bordet, M. Descamps, E. Dudognon, W. Pagnoux, J.-F. Willart, Structural Transformations of d -Mannitol Induced by in Situ Milling Using Real Time Powder Synchrotron Radiation Diffraction, Crystal Growth & Design 17, 6111-6122 (2017), [doi: 10.1021/acs.cgd.7b01283, LillOA]
13. A. Benazzouz, E. Dudognon, N. T. Correia, V. Molinier, J.-M. Aubry, M. Descamps, Interactions underpinning the plasticization of a polymer matrix: a dynamic and structural analysis of DMP-plasticized cellulose acetate, Cellulose 24, 487-503 (2017), [doi: 10.1007/s10570-016-1148-y, LillOA]
12. B. Schammé, N. Couvrat, P. Malpeli, E. Dudognon, L. Delbreilh, V. Dupray, E. Dargent, G. Coquerel, Transformation of an active pharmaceutical ingredient upon high-energy milling: A process-induced disorder in Biclotymol, International Journal of Pharmaceutics 499, 67-73 (2016), [doi: 10.1016/j.ijpharm.2015.12.032, LillOA]
11. P. Bordet, A. Bytchkov, M. Descamps, E. Dudognon, E. Elkaïm, P. Martinetto, W. Pagnoux, A. Poulain, J.-F. willart, Solid State Amorphization of β-Trehalose: A Structural Investigation Using Synchrotron Powder Diffraction and PDF Analysis, Crystal Growth & Design 16, 4547-4558 (2016), [doi: 10.1021/acs.cgd.6b00660, LillOA]
10. M. Descamps, E. Dudognon, Crystallization from the Amorphous State: Nucleation-Growth Decoupling, Polymorphism Interplay, and the Role of Interfaces, Journal of Pharmaceutical Sciences 103, 2615-2628 (2014), [doi: 10.1002/jps.24016, LillOA]
9. A. Mahieu, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, A new protocol to determine the solubility of drugs into polymer matrixes, Molecular Pharmaceutics 10, 560-566 (2013), [doi: 10.1021/mp3002254, LillOA]
8. A. Mahieu, J.-F. willart, E. Dudognon, M.D. Eddleston, W. Jones, F. Danede, M. Descamps, On the polymorphism of griseofulvin: Identification of two additional polymorphs, Journal of Pharmaceutical Sciences 102, 462-468 (2013), [doi: 10.1002/jps.23349, LillOA]
7. N. Dujardin, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, Mechanism of Solid State Amorphization of Glucose upon Milling, The Journal of Physical Chemistry B 117, 1437-1443 (2013), [doi: 10.1021/jp3069267, LillOA]
6. E. Dudognon, N. T. Correia, F. Danede, M. Descamps, Solid-Solid Transformation in Racemic Ibuprofen, Pharmaceutical Research 30, 81-89 (2013), [doi: 10.1007/s11095-012-0851-0, LillOA]
5. A. Hedoux, Y. Guinet, P. Derollez, E. Dudognon, N. T. Correia, Raman spectroscopy of racemic ibuprofen: Evidence of molecular disorder in phase II, International Journal of Pharmaceutics 421, 45-52 (2011), [doi: 10.1016/j.ijpharm.2011.09.015, LillOA]
4. N. Tabary, A. Mahieu, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, m. Bacquet, B. Martel, Characterization of the hidden glass transition of amorphous cyclomaltoheptaose, Carbohydrate research 346, 2193-2199 (2011), [doi: 10.1016/j.carres.2011.07.010, LillOA]
3. N. Dujardin, E. Dudognon, J.-F. willart, A. Hedoux, Y. Guinet, L. Paccou, M. Descamps, Solid state mutarotation of glucose, J. Phys. Chem. B 115, 1698-1705 (2011), [doi: 10.1021/jp109382j, LillOA]
2. N. Dujardin, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, First obtaining of glass solutions and phase diagram of glucose with fully tunable anomeric concentration, Journal of Pharmaceutical Sciences 99, 1476 - 1483 (2010), [doi: 10.1002/jps.21900, LillOA]
1. J.-F. willart, N. Dujardin, E. Dudognon, F. Danede, M. Descamps, Amorphization of sugar hydrates upon milling, Carbohydrate research 345, 1613 (2010), [doi: 10.1016/j.carres.2010.04.014, LillOA]

Full list (The link could be slow)

Conference presentations

10. E. Dudognon, J.A. Bama, F. Affouard, Amorphous solid dispersions of Terfenadine into PVP: insights from the molecular mobility characterisation, Conférence invitée, 12th Conference on Broadband Dielectric Spectroscopy and its applications BDS 2024, Lisbon (Portugal), Portugal, Sep 2024 [LillOA]
9. p. Bordet, P. Martinetto, J.-F. Willart, M. Descamps, E. Dudognon, In-situ powder diffraction study of molecular compounds under high energy milling: from amorphization to solid state transformation, Communication dans un congrès sans actes, EPDIC 16 (16th European Powder Diffraction Conference), Edinburgh, Scotland, Royaume-Uni, Nov 2024 [LillOA]
8. J.-F. Willart, p. Bordet, M. Descamps, E. Dudognon, P. Martinetto, W. Pagnoux, Kinetics of polymorphic transformations of pharmaceuticals induced by mechanical milling, Communication dans un congrès sans actes, ISMANAM 2018 (25th international Symposium on Metastable, Amorphous and Nanostructured Materials), Rome, Italie, Nov 2024 [LillOA]
7. p. Bordet, P. Martinetto, W. Pagnoux, J.-F. Willart, M. Descamps, E. Dudognon, Etude in-situ de composés moléculaires sous broyage à haute énergie: de l'amorphisation à la transformation à l'état solide, Communication dans un congrès sans actes, AFC 2018 (16th European Powder Diffraction Conference), Lyon, France, Nov 2024 [LillOA]
6. J.-F. Willart, p. Bordet, P. Martinetto, E. Dudognon, J. Siepmann, F. Siepmann, Solid state transformations of pharmaceuticals induced by milling: Experimental and numerical kinetics investigations, Communication dans un congrès sans actes, INCOME 2020 (9th International Conference on Mechanochemistry and Mechanical Alloying, Cagliari, Italie, Nov 2024 [LillOA]
5. M. Descamps, J.-F. Willart, E. Dudognon, Milling As a Tool to Manipulate and Screen Amorphism and Polymorphism, Conférence invitée, 9th IDMRCS (9th International discussion meeting on relaxations in complex systems), Tsukuba, Japon, Nov 2024 [LillOA]
4. J.A. Bama, E. Dudognon, F. Affouard, Impact of very low concentration of water on the dynamics of amorphous pharmaceuticals, Conférence invitée, International Conference on Science and Technology of Pharmaceutical Glass, Tsukuba, Japon, Aug 2023 [LillOA]
3. N. Zupan, S. Van de Steene, T. De Beer, A. Mullertz, E. Dudognon, S. Florin Muschert, Polymeric matrices for controlled release of Glibenclamide: Miscibility and dissolution properties, Communication dans un congrès sans actes, 17th PSSRC Annual Symposium, Cambridge, Royaume-Uni, Aug 2023 [LillOA]
2. N. Zupan, S. Van de Steene, T. De Beer, E. Dudognon, S. Florin Muschert, Challenges in assessing polymer miscibility in pharmaceutical hot-melt extrudates, Poster, 4th European Conference on Pharmaceutics, Marseille, France, Mar 2023 [LillOA]
1. E. Dudognon, Apport de la spectroscopie de relaxation diélectrique pour la détection d'hétérogénéités structurales dans des matériaux d'intérêt pharmaceutique, Communication dans un congrès sans actes, Colloque Relations structures/propriétés Electriques dans les Polymères & Composites (GDR REEPOS 2023) & 3eme colloque Français sur la Spectroscopie Diélectrique appliquée aux Matériaux SDM 3, Toulouse, France, Jun 2023 [LillOA]

Full list (The link could be slow)