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Unité Matériaux et Transformations
CNRS UMR 8207 - Université de Lille

 
Jean-François WILLART
CNRS researcher
Bâtiment P5 - 229
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33(0)3 20 43 68 34
Fax: +33 (0)3 20 43 40 84
Email Send an email to  Jean-François WILLART: Send an email to Jean-François WILLART
ORCID Identifier 0000-0002-7911-3918
: 0000-0002-7911-3918

Research

Main theme : Investigation of physical properties of molecular materials in non equilibrium conditions : glasses and glass transition, metastability, kinetics of phases transformations. Current specific theme : Solid state amorphization and polymorphic transformations induced by mechanical milling. Application to therapeutic materials and to the current issues of the pharmaceutical formulation.

Defended PhD thesis

Latest scientific contributions in LillOA (Lille Open Archive)

Publications

  1. F. Ramos, J.-F. Willart, C. Neut, K. Agossa, J. Siepmann, F. Siepmann, In-situ forming PLGA implants: Towards less toxic solvents., International Journal of Pharmaceutics: X 657, 124121 (2024), [doi: 10.1016/j.ijpharm.2024.124121, LillOA]
  2. L.-A. Lefol, P. Bawuah, J.A. Zeitler, J. Verin, F. Danede, J.-F. Willart, F. Siepmann, J. Siepmann, Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel., International Journal of Pharmaceutics: X 6, 100220 (2024), [doi: 10.1016/j.ijpx.2023.100220, LillOA]
  3. A. Krupa, F. Danede, D. Majda, A. Węgrzyn, D. Strojewski, I. Kondera, J.-F. willart, High energy ball milling vs. nano spray drying in the development of supersaturated systems loaded with bosentan, European Journal of Pharmaceutics and Biopharmaceutics 188, 137-146 (2023), [doi: 10.1016/j.ejpb.2023.05.014, LillOA]
  4. S. Wachowiak, F. Danede, J.-F. Willart, F. Siepmann, J. Siepmann, M. Hamoudi, PLGA implants for controlled dexamethasone delivery: Impact of the polymer chemistry, Journal of Drug Delivery Science and Technology 86, 104648 (2023), [doi: 10.1016/j.jddst.2023.104648, LillOA]
  5. M. Latreche, J.-F. willart, Analysis of the Dissolution Mechanism of Drugs into Polymers: The Case of the PVP/Sulindac System, Pharmaceutics 15;5, 1505 (2023), [doi: 10.3390/pharmaceutics15051505, LillOA]
  6. C. Henaff, J. Siepmann, F. Siepmann, F. Danede, M.-N. Avettand-Fènoël, J. Verin, A. Fadel, J.-F. Willart, Exploration of the physical states of riboflavin (free base) by mechanical milling, International journal of pharmaceutics 645, 123416 (2023), [doi: 10.1016/j.ijpharm.2023.123416, LillOA]
  7. T. Rongthong, A. Qnouch, M. Maue Gehrke, L. Paccou, P. Oliveira, F. Danede, J. Verin, C. Vincent, J.-F. Willart, F. Siepmann, J. Siepmann, Silicone matrices for controlled dexamethasone release: toward a better understanding of the underlying mass transport mechanisms., Regenerative Biomaterials 10, rbad008 (2023), [doi: 10.1093/rb/rbad008, LillOA]
  8. T. Rongthong, A. Qnouch, M.M. Gehrke, F. Danede, J.-F. Willart, P.F.M. De Oliveira, L. Paccou, G. Tourrel, P. Stahl, J. Verin, P. Toulemonde, C. Vincent, F. Siepmann, J. Siepmann, Long term behavior of dexamethasone-loaded cochlear implants: In vitro & in vivo, International Journal of Pharmaceutics: X 4, 100141 (2022), [doi: 10.1016/j.ijpx.2022.100141, LillOA]
  9. C. Bassand, L. Benabed, J. Verin, F. Danede, L. Lefol, J.-F. willart, F. Siepmann, J. Siepmann, L. Benabed, Hot melt extruded PLGA implants loaded with ibuprofen: How heat exposure alters the physical drug state, Journal of Drug Delivery Science and Technology 73, 103432 (2022), [doi: 10.1016/j.jddst.2022.103432, LillOA]
  10. J.-F. willart, S. Ouerghemmi, N. Descamps, P. Heijboer, L. Paccou, F. Danede, M. Descamps, The melting of glucose, International Journal of Pharmaceutics 626, 122185 (2022), [doi: 10.1016/j.ijpharm.2022.122185, LillOA]
  11. A. Krupa, F. Danede, A. Węgrzyn, D. Majda, J.-F. willart, Thinking of bosentan repurposing – A study on dehydration and amorphization, International Journal of Pharmaceutics 622, 121846 (2022), [doi: 10.1016/j.ijpharm.2022.121846, LillOA]
  12. A. Dupont, M. Guerain, F. Danede, J.-F. willart, Evidence of transient amorphization during the polymorphic transformation of sorbitol induced by milling, International Journal of Pharmaceutics 121929 (2022), [doi: 10.1016/j.ijpharm.2022.121929, LillOA]
  13. Y. Benzine, F. Siepmann, C. Neut, F. Danede, J.-F. willart, J. Siepmann, y. karrout, Injection-molded capsule bodies and caps based on polymer blends for controlled drug delivery, European Journal of Pharmaceutics and Biopharmaceutics 168, 1-14 (2021), [doi: 10.1016/j.ejpb.2021.08.007, LillOA]
  14. M. Guerain, F. Affouard, C. Henaff, C. Dejoie, F. Danede, J. Siepmann, F. Siepmann, J.-F. Willart, Structure determination of riboflavin by synchrotron high-resolution powder X-ray diffraction, Acta Crystallographica Section C Structural Chemistry 77;12, 800-806 (2021), [doi: 10.1107/s2053229621012171, LillOA]
  15. A. Qnouch, V. Solarczyk, J. Verin, G. Tourrel, P. Stahl, F. Danede, J.-F. Willart, P.-E. Lemesre, C. Vincent, J. Siepmann, F. Siepmann, Dexamethasone-loaded cochlear implants: How to provide a desired “burst release”, International Journal of Pharmaceutics: X 100088 (2021), [doi: 10.1016/j.ijpx.2021.100088, LillOA]
  16. O. Cantin, F. Siepmann, J.-F. Willart, F. Danede, J. Siepmann, Y. Karrout, PEO hot melt extrudates for controlled drug delivery: Importance of the type of drug and loading, Journal of Drug Delivery Science and Technology 102238 (2020), [doi: 10.1016/j.jddst.2020.102238, LillOA]
  17. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, F. Danede, A. Hedoux, Contribution of low-frequency Raman spectroscopy to determine the solubility curves of drugs in polymers: The case of paracetamol/PVP, European Journal of Pharmaceutics and Biopharmaceutics 154, 222-227 (2020), [doi: 10.1016/j.ejpb.2020.07.012, LillOA]
  18. A. Dupont, M. Guerain, F. Danede, L. Paccou, Y. Guinet, A. Hedoux, J.-F. willart, Kinetics and mechanism of polymorphic transformation of sorbitol under mechanical milling, International Journal of Pharmaceutics 590, 119902 (2020), [doi: 10.1016/j.ijpharm.2020.119902, LillOA]
  19. M. Latreche, J.-F. willart, M. Guerain, A. Hedoux, F. Danede, Using Milling to Explore Physical States: The Amorphous and Polymorphic Forms of Sulindac, Journal of Pharmaceutical Sciences 108;8, 2635-2642 (2019), [doi: 10.1016/j.xphs.2019.03.017, LillOA]
  20. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, A. Hedoux, Polymorphism versus devitrification mechanism: Low-wavenumber Raman investigations in sulindac, International Journal of Pharmaceutics 567, 118476 (2019), [doi: 10.1016/j.ijpharm.2019.118476, LillOA]
  21. M. Latreche, J.-F. willart, M. Guerain, F. Danede, A. Hedoux, Interest of molecular/crystalline dispersions for the determination of solubility curves of drugs into polymers, International Journal of Pharmaceutics 118626 (2019), [doi: 10.1016/j.ijpharm.2019.118626, LillOA]

Full list (The link could be slow)

Conference presentations

  1. A. Krupa, F. Danede, A. Węgrzyn, J.-F. Willart, How to enhance the solubility of bosentan?, Poster, 13th Central European Symposium on Pharmaceutical Technology, Gdansk, Pologne, Jun 2024 [LillOA]
  2. A. Krupa, F. Danede, I. Kondera, A. Węgrzyn, J.-F. Willart, The co-milled molecular alloys bosnetan / copovidone as a green way to create supersaturation in the git, Poster, AAPS PharmSci 360, Philadelphia, Etats-Unis d'Amérique, Jun 2024 [LillOA]
  3. C. Henaff, J. Siepmann, F. Siepmann, J.-F. Willart, Solid state amorphization of riboflavin upon milling, Poster, 15th PSSRC: Pharmaceutical Solid State Research Cluster, Online, France, Jun 2024 [LillOA]
  4. C. Henaff, J. Siepmann, F. Siepmann, J.-F. Willart, Solid state amorphization of Chlorhexidine chlorhexidine upon milling, Poster, 16th PSSRC: Pharmaceutical Solid State Research Cluster, Helsinki, Finlande, Jun 2024 [LillOA]
  5. J.-F. Willart, S. Ouerghemmi, N. Descamps, P. Heijboer, M. Descamps, Mécanisme de liquéfaction du glucose, Poster, Conférence International Matériaux 2022, Lille, France, Jun 2024 [LillOA]
  6. A. Dupont, M. Guerain, J.-F. Willart, Cinétique de transformation de phase de produits pharmaceutiques sous broyage, Poster, Conférence International Matériaux 2022, Lille, France, Jun 2024 [LillOA]
  7. A. Dupont, M. Guerain, J.-F. Willart, Effet de la température sur les cinétiques d'amorphisation des matériaux moléculaires par broyage mécanique, Poster, Conférence International Matériaux 2022, Lille, France, Jun 2024 [LillOA]
  8. D. Strojewski, S. Lalik, F. Danede, M. Marzec, J.-F. Willart, A. Krupa, Design of co-amorphous fixed-dose combinations of bosentan and sildenafil base, Poster, 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Vienne (Austria), Autriche, Jun 2024 [LillOA]
  9. C. Henaff, J. Siepmann, F. Siepmann, J.-F. Willart, Amorphous chlorhexidine (free base) dissolves less rapidly compared to crystalline, Poster, 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Vienne (Austria), Autriche, Jun 2024 [LillOA]
  10. Y. Bedulho Das Lages, N. Milanino, J. Verin, J.-F. Willart, F. Danede, C. Vincent, P. Bawuah, J. Zeitler, F. Siepmann, J. Siepmann, EVA implants for controlled drug delivery to the inner ear, Poster, 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Vienne (Austria), Autriche, Jun 2024 [LillOA]

Full list (The link could be slow)

 

Patents (old list, before 2018)

  1. 2017 - B. Martel, N. Blanchemain, M. P. Flament, J. F. Willart, N. Tabary, M. J. Garcia-Fernandez: Utilisation de fractions solubles, insolubles d'un polymère de cyclodextrine ou de leurs mélanges comme excipient dans un comprimé.
    Brevet français FR3040883 déposé le 14/09/2015 Numéro de publication internationale : WO2017/046506 A1
 
UMET - Unité Matériaux et Transformations
CNRS UMR 8207
Université de Lille
Bâtiment C6
59655 Villeneuve d'Ascq
France
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