Jean-François WILLART

CNRS researcher

Bâtiment P5 - 229
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33(0)3 20 43 68 34
Fax: +33 (0)3 20 43 40 84
Email : Send an email to Jean-François WILLART
ORCID Identifier : 0000-0002-7911-3918

Research team: Matériaux moléculaires et thérapeutiques

Research

Main theme : Investigation of physical properties of molecular materials in non equilibrium conditions : glasses and glass transition, metastability, kinetics of phases transformations. Current specific theme : Solid state amorphization and polymorphic transformations induced by mechanical milling. Application to therapeutic materials and to the current issues of the pharmaceutical formulation.

Defended PhD thesis

• Charline HENAFF, formulation in the amorphous state. Thesis defended in 2023.
• Anthony DUPONT, Investigations cinétiques des transformations de phase des matériaux pharmaceutiques sous broyage. Thesis defended in 2022. Other co-advisor: Mathieu GUERAIN.
• Mansour LATRECHE, Maitrise de la stabilité physique des alliages moléculaires amorphes pour optimiser l'efficacité des médicaments . Thesis defended in 2019. Position: EVOTEC.
• Frédéric NGONO MEBENGA, Study of amorphous pharmaceutical materials by molecular dynamics simulation and neutron scattering. Thesis defended in 2017. Other co-advisor: Frédéric AFFOUARD.
• Ahmed Mourad Salah, Effect of mechanical milling on the physical state of glassy pharmaceutical materials. Thesis defended in 2015. Position: Développeur JAVA J2EE, Open.
• Aurélien Mahieu, New methods to determine polymer / drug solubility diagrams. Thesis defended in 2013. Other co-advisor: Emeline DUDOGNON. Position: CDI / Société ADOCIS "Rédacteur Technique Crédit Impôt Recherche (CIR)" à Angers.
• Nicolas Dujardin, Solid State Amorphization of Glucose and Control of the Mutarotation. Thesis defended in 2009. Other co-advisor: Emeline DUDOGNON.
• Vincent Caron, Mecanosynthesis of molecular alloys. Thesis defended in 2006. Other co-advisor: Marc DESCAMPS. Position: Post-doctorat à l'Université de Dublin.
• Armelle De Gusseme, Transformation athermique de matériaux pharmaceutiques. Thesis defended in 2003. Other co-advisor: Marc DESCAMPS. Position: Principal scientist, laboratoire GSK.
• Marlène Tétaert, Dynamical Study of Plastic Molecular Crystals. Thesis defended in 2001. Other co-advisor: Marc DESCAMPS.

Latest scientific contributions in LillOA (Lille Open Archive)

Publications

21. Y. Bedulho das Lages, N. Milanino, J. Verin, J.-F. Willart, F. Danede, C. Vincent, P. Bawuah, J. Zeitler, F. Siepmann, J. Siepmann, EVA implants for controlled drug delivery to the inner ear, International Journal of Pharmaceutics: X 8, 100271 (2024), [doi: 10.1016/j.ijpx.2024.100271, LillOA]
20. D. Strojewski, S. Lalik, F. Danede, N. Górska, A. Deptuch, M. Marzec, J.-F. Willart, A. Krupa, Bosentan monohydrate and sildenafil base as two companions in enabling formulations, International journal of pharmaceutics 661, 124312 (2024), [doi: 10.1016/j.ijpharm.2024.124312, LillOA]
19. F. Ramos, J.-F. Willart, C. Neut, K. Agossa, J. Siepmann, F. Siepmann, In-situ forming PLGA implants: Towards less toxic solvents., International Journal of Pharmaceutics: X 657, 124121 (2024), [doi: 10.1016/j.ijpharm.2024.124121, LillOA]
18. L.-A. Lefol, P. Bawuah, J.A. Zeitler, J. Verin, F. Danede, J.-F. Willart, F. Siepmann, J. Siepmann, Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel., International Journal of Pharmaceutics: X 6, 100220 (2024), [doi: 10.1016/j.ijpx.2023.100220, LillOA]
17. A. Krupa, F. Danede, D. Majda, A. Węgrzyn, D. Strojewski, I. Kondera, J.-F. willart, High energy ball milling vs. nano spray drying in the development of supersaturated systems loaded with bosentan, European Journal of Pharmaceutics and Biopharmaceutics 188, 137-146 (2023), [doi: 10.1016/j.ejpb.2023.05.014, LillOA]
16. S. Wachowiak, F. Danede, J.-F. Willart, F. Siepmann, J. Siepmann, M. Hamoudi, PLGA implants for controlled dexamethasone delivery: Impact of the polymer chemistry, Journal of Drug Delivery Science and Technology 86, 104648 (2023), [doi: 10.1016/j.jddst.2023.104648, LillOA]
15. M. Latreche, J.-F. willart, Analysis of the Dissolution Mechanism of Drugs into Polymers: The Case of the PVP/Sulindac System, Pharmaceutics 15;5, 1505 (2023), [doi: 10.3390/pharmaceutics15051505, LillOA]
14. C. Henaff, J. Siepmann, F. Siepmann, F. Danede, M.-N. Avettand-Fènoël, J. Verin, A. Fadel, J.-F. Willart, Exploration of the physical states of riboflavin (free base) by mechanical milling, International journal of pharmaceutics 645, 123416 (2023), [doi: 10.1016/j.ijpharm.2023.123416, LillOA]
13. T. Rongthong, A. Qnouch, M. Maue Gehrke, L. Paccou, P. Oliveira, F. Danede, J. Verin, C. Vincent, J.-F. Willart, F. Siepmann, J. Siepmann, Silicone matrices for controlled dexamethasone release: toward a better understanding of the underlying mass transport mechanisms., Regenerative Biomaterials 10, rbad008 (2023), [doi: 10.1093/rb/rbad008, LillOA]
12. T. Rongthong, A. Qnouch, M.M. Gehrke, F. Danede, J.-F. Willart, P.F.M. De Oliveira, L. Paccou, G. Tourrel, P. Stahl, J. Verin, P. Toulemonde, C. Vincent, F. Siepmann, J. Siepmann, Long term behavior of dexamethasone-loaded cochlear implants: In vitro & in vivo, International Journal of Pharmaceutics: X 4, 100141 (2022), [doi: 10.1016/j.ijpx.2022.100141, LillOA]
11. C. Bassand, L. Benabed, J. Verin, F. Danede, L. Lefol, J.-F. willart, F. Siepmann, J. Siepmann, L. Benabed, Hot melt extruded PLGA implants loaded with ibuprofen: How heat exposure alters the physical drug state, Journal of Drug Delivery Science and Technology 73, 103432 (2022), [doi: 10.1016/j.jddst.2022.103432, LillOA]
10. J.-F. willart, S. Ouerghemmi, N. Descamps, P. Heijboer, L. Paccou, F. Danede, M. Descamps, The melting of glucose, International Journal of Pharmaceutics 626, 122185 (2022), [doi: 10.1016/j.ijpharm.2022.122185, LillOA]
9. A. Krupa, F. Danede, A. Węgrzyn, D. Majda, J.-F. willart, Thinking of bosentan repurposing – A study on dehydration and amorphization, International Journal of Pharmaceutics 622, 121846 (2022), [doi: 10.1016/j.ijpharm.2022.121846, LillOA]
8. A. Dupont, M. Guerain, F. Danede, J.-F. willart, Evidence of transient amorphization during the polymorphic transformation of sorbitol induced by milling, International Journal of Pharmaceutics 121929 (2022), [doi: 10.1016/j.ijpharm.2022.121929, LillOA]
7. Y. Benzine, F. Siepmann, C. Neut, F. Danede, J.-F. willart, J. Siepmann, y. karrout, Injection-molded capsule bodies and caps based on polymer blends for controlled drug delivery, European Journal of Pharmaceutics and Biopharmaceutics 168, 1-14 (2021), [doi: 10.1016/j.ejpb.2021.08.007, LillOA]
6. M. Guerain, F. Affouard, C. Henaff, C. Dejoie, F. Danede, J. Siepmann, F. Siepmann, J.-F. Willart, Structure determination of riboflavin by synchrotron high-resolution powder X-ray diffraction, Acta Crystallographica Section C Structural Chemistry 77;12, 800-806 (2021), [doi: 10.1107/s2053229621012171, LillOA]
5. A. Qnouch, V. Solarczyk, J. Verin, G. Tourrel, P. Stahl, F. Danede, J.-F. Willart, P.-E. Lemesre, C. Vincent, J. Siepmann, F. Siepmann, Dexamethasone-loaded cochlear implants: How to provide a desired “burst release”, International Journal of Pharmaceutics: X 100088 (2021), [doi: 10.1016/j.ijpx.2021.100088, LillOA]
4. O. Cantin, F. Siepmann, J.-F. Willart, F. Danede, J. Siepmann, Y. Karrout, PEO hot melt extrudates for controlled drug delivery: Importance of the type of drug and loading, Journal of Drug Delivery Science and Technology 102238 (2020), [doi: 10.1016/j.jddst.2020.102238, LillOA]
3. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, F. Danede, A. Hedoux, Contribution of low-frequency Raman spectroscopy to determine the solubility curves of drugs in polymers: The case of paracetamol/PVP, European Journal of Pharmaceutics and Biopharmaceutics 154, 222-227 (2020), [doi: 10.1016/j.ejpb.2020.07.012, LillOA]
2. A. Dupont, M. Guerain, F. Danede, L. Paccou, Y. Guinet, A. Hedoux, J.-F. willart, Kinetics and mechanism of polymorphic transformation of sorbitol under mechanical milling, International Journal of Pharmaceutics 590, 119902 (2020), [doi: 10.1016/j.ijpharm.2020.119902, LillOA]
1. M. Latreche, J.-F. willart, M. Guerain, A. Hedoux, F. Danede, Using Milling to Explore Physical States: The Amorphous and Polymorphic Forms of Sulindac, Journal of Pharmaceutical Sciences 108;8, 2635-2642 (2019), [doi: 10.1016/j.xphs.2019.03.017, LillOA]

Full list (The link could be slow)

Conference presentations

10. A. Krupa, F. Danede, A. Węgrzyn, J.-F. Willart, How to enhance the solubility of bosentan?, Poster, 13th Central European Symposium on Pharmaceutical Technology, Gdansk, Pologne, Nov 2024 [LillOA]
9. A. Krupa, F. Danede, I. Kondera, A. Węgrzyn, J.-F. Willart, The co-milled molecular alloys bosnetan / copovidone as a green way to create supersaturation in the git, Poster, AAPS PharmSci 360, Philadelphia, Etats-Unis d'Amérique, Nov 2024 [LillOA]
8. C. Henaff, J. Siepmann, F. Siepmann, J.-F. Willart, Solid state amorphization of riboflavin upon milling, Poster, 15th PSSRC: Pharmaceutical Solid State Research Cluster, Online, France, Nov 2024 [LillOA]
7. C. Henaff, J. Siepmann, F. Siepmann, J.-F. Willart, Solid state amorphization of Chlorhexidine chlorhexidine upon milling, Poster, 16th PSSRC: Pharmaceutical Solid State Research Cluster, Helsinki, Finlande, Nov 2024 [LillOA]
6. J.-F. Willart, S. Ouerghemmi, N. Descamps, P. Heijboer, M. Descamps, Mécanisme de liquéfaction du glucose, Poster, Conférence International Matériaux 2022, Lille, France, Nov 2024 [LillOA]
5. A. Dupont, M. Guerain, J.-F. Willart, Cinétique de transformation de phase de produits pharmaceutiques sous broyage, Poster, Conférence International Matériaux 2022, Lille, France, Nov 2024 [LillOA]
4. A. Dupont, M. Guerain, J.-F. Willart, Effet de la température sur les cinétiques d'amorphisation des matériaux moléculaires par broyage mécanique, Poster, Conférence International Matériaux 2022, Lille, France, Nov 2024 [LillOA]
3. D. Strojewski, S. Lalik, F. Danede, M. Marzec, J.-F. Willart, A. Krupa, Design of co-amorphous fixed-dose combinations of bosentan and sildenafil base, Poster, 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Vienne (Austria), Autriche, Nov 2024 [LillOA]
2. C. Henaff, J. Siepmann, F. Siepmann, J.-F. Willart, Amorphous chlorhexidine (free base) dissolves less rapidly compared to crystalline, Poster, 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Vienne (Austria), Autriche, Nov 2024 [LillOA]
1. Y. Bedulho Das Lages, N. Milanino, J. Verin, J.-F. Willart, F. Danede, C. Vincent, P. Bawuah, J. Zeitler, F. Siepmann, J. Siepmann, EVA implants for controlled drug delivery to the inner ear, Poster, 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Vienne (Austria), Autriche, Nov 2024 [LillOA]

Full list (The link could be slow)

Patents (old list, before 2018)

1. 2017 - B. Martel, N. Blanchemain, M. P. Flament, J. F. Willart, N. Tabary, M. J. Garcia-Fernandez: Utilisation de fractions solubles, insolubles d'un polymère de cyclodextrine ou de leurs mélanges comme excipient dans un comprimé.
   Brevet français FR3040883 déposé le 14/09/2015 Numéro de publication internationale : WO2017/046506 A1