Jean-François WILLART

CNRS researcher

Bâtiment P5 - 229
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33(0)3 20 43 68 34
Fax: +33 (0)3 20 43 40 84
Email : Send an email to Jean-François WILLART
ORCID Identifier : 0000-0002-7911-3918

Research team: Matériaux moléculaires et thérapeutiques

Research

Main theme : Investigation of physical properties of molecular materials in non equilibrium conditions : glasses and glass transition, metastability, kinetics of phases transformations. Current specific theme : Solid state amorphization and polymorphic transformations induced by mechanical milling. Application to therapeutic materials and to the current issues of the pharmaceutical formulation.

Current PhD thesis

• Hornela YEMENE TAGOUE, Conception d'alliages moléculaires amorphes agro sourcés pour améliorer l'efficacité des médicaments. Thesis started in 2024. Other co-advisor: Juergen SIEPMANN.

Defended PhD thesis

• Charline HENAFF, formulation in the amorphous state. Thesis defended in 2023. Position: Principal scientist at BePharmBel Manufacturing SA.
• Anthony DUPONT, Investigations cinétiques des transformations de phase des matériaux pharmaceutiques sous broyage. Thesis defended in 2022. Other co-advisor: Mathieu GUERAIN.
• Mansour LATRECHE, Maitrise de la stabilité physique des alliages moléculaires amorphes pour optimiser l'efficacité des médicaments . Thesis defended in 2019. Position: Cadre de Laboratoire Etats solides chez EVOTEC.
• Frédéric NGONO MEBENGA, Study of amorphous pharmaceutical materials by molecular dynamics simulation and neutron scattering. Thesis defended in 2017. Other co-advisor: Frédéric AFFOUARD. Position: Principal scientist at JANSSEN Pharmaceutica N.V.
• Ahmed Mourad Salah, Effect of mechanical milling on the physical state of glassy pharmaceutical materials. Thesis defended in 2015. Position: Développeur JAVA J2EE, Open.
• Aurélien Mahieu, New methods to determine polymer / drug solubility diagrams. Thesis defended in 2013. Other co-advisor: Emeline DUDOGNON. Position: CDI / Société ADOCIS "Rédacteur Technique Crédit Impôt Recherche (CIR)" à Angers.
• Nicolas Dujardin, Solid State Amorphization of Glucose and Control of the Mutarotation. Thesis defended in 2009. Other co-advisor: Emeline DUDOGNON.
• Vincent Caron, Mecanosynthesis of molecular alloys. Thesis defended in 2006. Other co-advisor: Marc DESCAMPS. Position: Post-doctorat à l'Université de Dublin.
• Armelle De Gusseme, Transformation athermique de matériaux pharmaceutiques. Thesis defended in 2003. Other co-advisor: Marc DESCAMPS. Position: Principal scientist, laboratoire GSK.
• Marlène Tétaert, Dynamical Study of Plastic Molecular Crystals. Thesis defended in 2001. Other co-advisor: Marc DESCAMPS.

Patents (old list, before 2018)

1. 2017 - B. Martel, N. Blanchemain, M. P. Flament, J. F. Willart, N. Tabary, M. J. Garcia-Fernandez: Utilisation de fractions solubles, insolubles d'un polymère de cyclodextrine ou de leurs mélanges comme excipient dans un comprimé.
   Brevet français FR3040883 déposé le 14/09/2015 Numéro de publication internationale : WO2017/046506 A1