Matériaux Moléculaires et Thérapeutiques - Scientific instruments

ATG Q500 (TA Instruments)

Research team: Matériaux moléculaires et thérapeutiques.

Contact: Florence DANEDE.

Characterization of solvent losses and degradations in molecular materials
Temperature range: from 30 ° C to 550 ° C

microcalorimeter MicroDSC7 evo (Setaram)

Research team: Matériaux moléculaires et thérapeutiques.

Contacts: Alain HEDOUX, Laurent PACCOU.

the μDSC7 evo can meet the requirements of a wide range of applications, especially in the following areas:
- Life sciences - pharmaceutical: protein denaturation / aggregation in solution, powder or gel, solid state polymorphism, amorphism,
- Food: protein denaturation / aggregation, polysaccharide fusion / gelation, gelatin, starch, emulsion stability,
- Polymers: influence of pressure on glass transitions to supercritical conditions,
technical characteristics

• temperature range -45 ° C to 120 ° C
• programming speed from 0.001 to 2 ° C per min,
• Hastelloy cell volume up to 1 mL
• Use in isothermal mode (calorimeter) or temperature programming (DSC).
• Ability to study samples in all forms: liquid, gel, powder, solid.

Raman µspectrometer Renishaw InVia , suitable for medium-frequency studies (150-1800 cm-1)

Research team: Matériaux moléculaires et thérapeutiques.

Contacts: Yannick GUINET, Alain HEDOUX, Laurent PACCOU.

Analysis of the dynamics of glass-forming molecular materials in their amorphous and crystalline states, mechanisms of phase transformation, and stabilization of amorphous states of materials of therapeutic interest (small molecules, proteins) by excipients

• lasers lmbda = 514 nm and 785 nm

Sample environment

• Platinum LinKam Scientific Instrument see part Heat treatment
• XYZ Platinum for cartography
• Anvil cell diamond Chervin type pressure generator 40 GPa
• CryoDAC-ST (Alamax Easy lab) cryoDAC-ST anvils cell pressure 15 GPa max and cryostat ST500b (Janis) temperature control from 3.5K to 475K.
• Humidity Controlled Platinum GenRH (Surface Measurement Systems)
• HR from 1 to 98% accuracy 0.8%

Raman Spectrometer XY Dilor, suitable for Low Frequency Macro Studies (5-500 cm-1)

Research team: Matériaux moléculaires et thérapeutiques.

Contacts: Alain HEDOUX, Yannick GUINET, Laurent PACCOU.

X-ray diffractometer on powders, X'Pert Pro (Panalytical)

Research team: Matériaux moléculaires et thérapeutiques.

Platform: Plateau d’analyses par diffraction des Rayons X.

Contacts: Mathieu GUERAIN, Florence DANEDE.