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Unité Matériaux et Transformations
CNRS UMR 8207 - Université de Lille

AFFOUARD Frédéric
Frédéric AFFOUARD
Professor
Bâtiment P5 - 221
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33 (0)3 20 43 68 15
Fax: +33 (0)3 20 43 40 84
Email Send an email to  Frédéric AFFOUARD: Send an email to Frédéric AFFOUARD
ORCID Identifier 0000-0001-8429-6416: 0000-0001-8429-6416

Research

Physical states of molecular materials. Physical mechanisms of the glass transition of molecular materials composed of small organic molecules (glassy crystals, liquids). Optimization of the stability of biomolecules. Molecular dynamics simulation. Neutron scattering.

Teaching

Faculty of Sciences - Department of Physics : -  2nd and 3rd year: "Students Projects: Innovative Materials and Green chemistry" - Master1 (Physics of the XXIst century ): "Thermodynamics & Statistical Physics" - Master2: (Materials, Molecules and their Environnements) "Phase transformation", "Molecular modelling". Coordinator of the Erasmus Mundus BIOPHAM Master  "bio&Pharmaceutical Materials Science" https://www.master-biopham.eu

Current PhD thesis

Defended PhD thesis

Latest scientific contributions in LillOA (Lille Open Archive)

Publications

  1. A. Shagurin, F.-A. Miannay, M.G. Kiselev, P. Jedlovszky, F. Affouard, N. Idrissi, A. Idrissi, Widom Line in Supercritical Water in Terms of Changes in Local Structure: Theoretical Perspective, The Journal of Physical Chemistry Letters 15, 5831-5837 (2024), [doi: 10.1021/acs.jpclett.4c01142, LillOA]
  2. S. Samsoen, E. Dudognon, G. Le Fer, D. Fournier, P. Woisel, F. Affouard, Impact of the Polymer Dispersity on the Properties of Curcumin/Polyvinylpyrrolidone Amorphous Solid Dispersions, International Journal of Pharmaceutics 653, 123895 (2024), [doi: 10.1016/j.ijpharm.2024.123895, LillOA]
  3. M. Guerain, N. T. Correia, L.-V. Roca Paixao, H. Chevreau, F. Affouard, Using synchrotron high-resolution powder X-ray diffraction for the structure determination of a new cocrystal formed by two active principle ingredients, Acta Crystallographica Section C Structural Chemistry 80;2, 37-42 (2024), [doi: 10.1107/s2053229624000639, LillOA]
  4. A. Shagurin, M. Kiselev, P. Jedlovszky, F. Affouard, N. Idrissi, Analysis of the effect of the translational-rotational coupling on the pseudo-diffusion along the molecular axes of meta-cresol: A molecular dynamics analysis, Journal of Molecular Liquids 390, (2023), [doi: 10.1016/j.molliq.2023.123181, LillOA]
  5. T. Cordeiro, I. Matos, F. Danede, J.C. Sotomayor, I.M. Fonseca, M.C. Corvo, M. Dionísio, M.T. Viciosa, F. Affouard, N. T. Correia, Evidence of Strong Guest–Host Interactions in Simvastatin Loaded in Mesoporous Silica MCM-41, Pharmaceutics 15;5, 1320 (2023), [doi: 10.3390/pharmaceutics15051320, LillOA]
  6. L.-V. Roca Paixao, N. T. Correia, F. Danede, M. Guerain, F. Affouard, Carbamazepine/Tartaric Acid Cocrystalline Forms: When Stoichiometry and Synthesis Method Matter, Crystal Growth & Design 23;3, 1355-1369 (2023), [doi: 10.1021/acs.cgd.2c00859, LillOA]
  7. L.-V. Roca Paixao, N. T. Correia, F. Danede, M.T. Viciosa, A.L. Morritt, Y.Z. Khimyak, F. Affouard, Nature of the Structural and Dynamical Disorder in Organic Cocrystals with a True Nanometric Size Channel-Like Architecture, Crystal Growth & Design 23;1, 120-133 (2023), [doi: 10.1021/acs.cgd.2c00815, LillOA]
  8. K. Koperwas, F. Kaśkosz, A. Grzybowski, M. Paluch, F. Affouard, The role of the diffusion in the predictions of the classical nucleation theory for quasi-real systems differ in dipole moment value, Scientific Reports 12;1, (2022), [doi: 10.1038/s41598-022-13715-y, LillOA]
  9. M. Guerain, F. Affouard, C. Henaff, C. Dejoie, F. Danede, J. Siepmann, F. Siepmann, J.-F. Willart, Structure determination of riboflavin by synchrotron high-resolution powder X-ray diffraction, Acta Crystallographica Section C Structural Chemistry 77;12, 800-806 (2021), [doi: 10.1107/s2053229621012171, LillOA]
  10. B. Atawa, N. Couvrat, F. Affouard, N. T. Correia, G. Coquerel, A. Saiter-Fourcin, Impact of chirality on the amorphous state of conglomerate forming systems: a case study of N-acetyl-α-methylbenzylamine, Physical Chemistry Chemical Physics 23;42, 24282-24293 (2021), [doi: 10.1039/d1cp03843e, LillOA]
  11. K. Koperwas, W. Tu, F. Affouard, K. Adrjanowicz, F. Kaskosz, M. Paluch, Pressure Dependence of the Crystallization Rate for the S-Enantiomer and a Racemic Mixture of Ibuprofen, Crystal Growth & Design (2021), [doi: 10.1021/acs.cgd.1c00980, LillOA]
  12. Z. Li, J. Wang, S. Pan, F. Affouard, S. Zhang, S. Feng, Y. Liu, L.-m. Wang, A new criterion for glass-forming ability based on both devitrification and solidification processes, Intermetallics 136, 107264 (2021), [doi: 10.1016/j.intermet.2021.107264, LillOA]
  13. J.A. Bama, E. Dudognon, F. Affouard, Impact of Low Concentration of Strongly Hydrogen-Bonded Water Molecules on the Dynamics of Amorphous Terfenadine: Insights from Molecular Dynamics Simulations and Dielectric Relaxation Spectroscopy, The Journal of Physical Chemistry B 125;40, p. 11292-11307 (2021), [doi: 10.1021/acs.jpcb.1c06087, LillOA]
  14. M.G. Kiselev, N. Idrissi, F. Affouard, The problems of solvation, complex formation and crystallization challenging the development of smart materials Preface, Journal of Molecular Liquids 300, (2020), [doi: 10.1016/j.molliq.2019.112197, LillOA]
  15. M. Guerain, P. Derollez, L.-V. Roca Paixao, C. Dejoie, N. T. Correia, F. Affouard, Structure determination of Carbamazepine/DL-TA co-crystal by synchrotron powder X-ray diffraction, Acta Crystallographica Section C Structural Chemistry 76, (2020), [LillOA]
  16. F. Ngono, G.J. Cuello, M. Jimenez-Ruiz, J.-F. Willart, M. Guerain, A.R. Wildes, A. Stunault, M. Hamoudi, F. Affouard, Morphological and structural properties of amorphous lactulose studied by scanning electron microscopy, polarised neutron scattering, and molecular dynamics simulations, Molecular Pharmaceutics 17, 10-20 (2020), [doi: 10.1021/acs.molpharmaceut.9b00767, LillOA]
  17. F. Ngono, J.-F. Willart, G.J. Cuello, M. Jimenez-Ruiz, M. Hamoudi, F. Affouard, Impact of amorphisation methods on the physico-chemical properties of amorphous lactulose, Molecular Pharmaceutics 17, 1-9 (2020), [doi: 10.1021/acs.molpharmaceut.9b00740, LillOA]
  18. J. Gerges, F. Affouard, Insight from molecular dynamics simulations on the crystallization tendency of indomethacin polymorphs in the undercooled liquid state, Journal of Pharmaceutical Sciences 109, 1086-1095 (2020), [doi: 10.1016/j.xphs.2019.10.054, LillOA]
  19. E. Dudognon, F. Affouard, J.A. Bama, Molecular Mobility of Terfenadine: Investigation by Dielectric Relaxation Spectroscopy and Molecular Dynamics Simulation, Molecular Pharmaceutics 16;11, 4711-4724 (2019), [doi: 10.1021/acs.molpharmaceut.9b00877, LillOA]
  20. L.-V. Roca Paixao, N. T. Correia, F. Affouard, Affinity prediction computations and mechanosynthesis of carbamazepine based cocrystals, Crystengcomm 21;45, 6991-7001 (2019), [doi: 10.1039/c9ce01160a, LillOA]
  21. F. Ngono Mebenga, J.-F. willart, G.J. Cuello, M. Jimenez-Ruiz, F. Affouard, Lactulose: a model system to investigate solid state amorphization induced by milling, Journal of Pharmaceutical Sciences 108, 880-887 (2019), [doi: 10.1016/j.xphs.2018.09.013, LillOA]

Full list (The link could be slow)

Conference presentations

  1. S. Laurette, A. Treizebre, B. Hatirnaz, L. Duponchel, F. Affouard, B. Bocquet, Laboratoire sur puce pour la métrologie des liquides : l'exemple de l'hydratation des alcools, Communication dans un congrès sans actes, Journées Franco-Libanaises Physique et Interfaces, JFLPI, Villeneuve d'Ascq, France, Jun 2024 [LillOA]
  2. F. Affouard, Applications de la modélisation moléculaire pour l'étude des matériaux pharmaceutiques, Séminaire de recherche, ORIL – SERVIER, Bolbec, France, Oct 2022 [LillOA]
  3. J.A. Bama, E. Dudognon, F. Affouard, Impact of very low concentration of water on the dynamics of amorphous pharmaceuticals, Conférence invitée, International Conference on Science and Technology of Pharmaceutical Glass, Tsukuba, Japon, Aug 2023 [LillOA]
  4. L.-V. Roca Paixao, N. T. Correia, F. Danede, M.T. Viciosa, A. Morritt, Y.Z. Khimyak, F. Affouard, Nature of the disorder in organic cocrystals of pharmaceutical interest with a channel-like architecture, Conférence invitée, 9th International Discussion Meeting on Relaxations in Complex Systems (9 IDMRCS), Chiba, Japon, Aug 2023 [LillOA]
  5. F. Affouard, Dynamical disorder in pharmaceutical co-crystalline systems, Communication dans un congrès sans actes, VISCOUS LIQUIDS AND THE GLASS TRANSITION (XIX), Holbæk, Danemark, Jun 2023 [LillOA]
  6. S. Samsoen, E. Dudognon, D. Fournier, G. Le Fer, P. Woisel, F. Affouard, Characterization of Curcumin/PVP amorphous solid dispersions, Poster, 4th European Conference on Pharmaceutics, Marseille, France, Mar 2023 [LillOA]
  7. E. Dudognon, J.A. Bama, F. Affouard, Probing dynamics of an amorphous drug by Dielectric Relaxation Spectroscopy and MD simulations: effect of low concentration strongly hydrogen-bonded water, Communication dans un congrès sans actes, 11th Conference on Broadband Dielectric Spectroscopy and its Applications (BDS2022), San Sebastian, Espagne, Sep 2022 [LillOA]
  8. S. Samsoen, E. Dudognon, G. Le Fer, D. Fournier, P. Woisel, F. Affouard, Solubility and stability of Curcumin inside well defined synthesised PVP matrices, Poster, 52èmes Journées de Calorimétrie et d’Analyse Thermique, Colmar, France, Jun 2022 [LillOA]
  9. S. Samsoen, E. Dudognon, G. Le Fer, D. Fournier, F. Affouard, P. Woisel, Well-defined polymeric matrices for the understanding of amorphous solid dispersions, Poster, 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Rotterdam, Pays-Bas, Mar 2022 [LillOA]
  10. Y.Z. Khimyak, L. Fabian, A. Morritt, M. Nowak, N. T. Correia, F. Affouard, M. T. Ruggiero, K.P. Nartowski, Understanding phase transitions and nature of disorder in pharmaceutical materials: polymorphs, co-crystals and nano-confined systems, Communication dans un congrès sans actes, Taming Disorder in Solid Materials, Durham, Royaume-Uni, Dec 2023 [LillOA]

Full list (The link could be slow)

 
 
UMET - Unité Matériaux et Transformations
CNRS UMR 8207
Université de Lille
Bâtiment C6
59655 Villeneuve d'Ascq
France
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