Marc DESCAMPS

Professor

Bâtiment P5 - 221
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33 (0)3 20 43 49 79
Fax: +33 (0)3 20 43 40 84
Email : Send an email to Marc DESCAMPS
ORCID Identifier :

Research team: Matériaux moléculaires et thérapeutiques

Research

Disordered molecular crystals: Glassy crystals, Kinetics of phase transformations, molecular mobility. Glass and glass transition. Physics of pharmaceutical solids. Driven molecular solids(Milling induced transformations)

Editing

• Book Disordered Pharmaceutical Materials (522 pages) Edited by Marc Descamps, May 2016 WILEY - VCH
• Special issue of Advanced Drug Delivery Reviews: Amorphous Pharmaceutical Solids (Theme editor: Marc Descamps) Volume 100, May 2016

Defended PhD thesis

• Anne-Amandine Decroix, Stabilité physique et désordre orientationnel dans un cristal à usage thérapeutique : la cafeine. Thesis defended in 2009. Other co-advisor: Laurent CARPENTIER. Position: Maître de conférences à l'Université d'Artois.
• Angeline Aumelas, Broyage de composés pharmaceutiques: changement d’état physique et manipulation de la stabilité. Thesis defended in 2008. Position: Ingénieur de recherche SNPE Matériaux Energétiques.
• Vincent Caron, Mecanosynthesis of molecular alloys. Thesis defended in 2006. Other co-advisor: Jean-François WILLART. Position: Post-doctorat à l'Université de Dublin.
• Adrien Lerbret, Study of the biopreservative capabilities of sugars: investigation from molecular dynamics and Raman spectroscopy. Thesis defended in 2005. Other co-advisors: Frédéric AFFOUARD, Alain HEDOUX. Position: Ingénieur de Recherche - Université de Bourgogne-AgroSup Dijon.
• Sylvain Desprez, Matériaux moléculaires forcés : recherche des forces motrices de transformation. Thesis defended in 2004. Position: Chercheur Materia Nova, Mons, Belgique.
• Armelle De Gusseme, Transformation athermique de matériaux pharmaceutiques. Thesis defended in 2003. Other co-advisor: Jean-François WILLART. Position: Principal scientist, laboratoire GSK.
• Thomas Denicourt, Etude spectroscopique de systèmes désordonnés profondément sous-refroidis . Thesis defended in 2002. Other co-advisor: Alain HEDOUX. Position: Responsable informatique.
• Marlène Tétaert, Dynamical Study of Plastic Molecular Crystals. Thesis defended in 2001. Other co-advisor: Jean-François WILLART.
• Olivier Bustin, Relaxation Structurale des matériaux vitrifiables par calorimétrie à balayage modulé. Thesis defended in 1999. Position: Responsable dans la banque.
• Valérie Legrand, Contribution à l'étude de la vitrification de liquides moléculaires fragiles. Thesis defended in 1996. Position: Ingénieur Recherche Société agro-alimentaire.
• Olivier Delcourt, Effet de taille et bistabilité thermodynamique dans le cyanoadamantane. Thesis defended in 1993. Position:  Responsable informatique laboratoire recherche Decathlon.
• Najib Benzakour, Phases stables et métastables d'un cristal vitreux. Thesis defended in 1992.
• Jean-François WILLART, Transformation de phase et brisure d'ergodicité dans un verre d'orientation. Thesis defended in 1991. Position: Chargé de recherches CNRS.
• Mohamed El Adib, Cinétique de transformation d'un cristal vitreux. Thesis defended in 1989.
• Claude Caucheteux, Etude par diffusion des rayons X de la cinétique d'évolution d'un verre d'orientation : le 1-cyanoadamantane, mécanisme de la transition vitreuse. Thesis defended in 1987. Position: Ingenieur Enraf Nonius.
• Patrick DEROLLEZ, Le succinonitrile: un cas de molécule déformable dans l'étude d'un cristal à désordre orientationnel. Thesis defended in 1984. Position: Maître de conférences au laboratoire.

Latest scientific contributions in LillOA (Lille Open Archive)

Publications

21. J.-F. willart, S. Ouerghemmi, N. Descamps, P. Heijboer, L. Paccou, F. Danede, M. Descamps, The melting of glucose, International Journal of Pharmaceutics 626, 122185 (2022), [doi: 10.1016/j.ijpharm.2022.122185, LillOA]
20. P.F.M. Oliveira, J.-F. willart, J. Siepmann, F. Siepmann, M. Descamps, Using Milling To Explore Physical States: The Amorphous and Polymorphic Forms of Dexamethasone, Crystal Growth & Design 18, 1748-1757 (2018), [doi: 10.1021/acs.cgd.7b01664, LillOA]
19. M. Descamps, J.-F. willart, Scaling laws and size effects for amorphous crystallization kinetics: Constraints imposed by nucleation and growth specificities, International journal of pharmaceutics 542, 186-195 (2018), [doi: 10.1016/j.ijpharm.2018.03.001, LillOA]
18. A. Mahieu, J.-F. willart, M. Guerain, P. Derollez, F. Danede, M. Descamps, Structure determination of phase II of the antifungal drug griseofulvin by powder X-ray diffraction, Acta Crystallographica Section C Structural Chemistry 74, 321-324 (2018), [doi: 10.1107/S2053229618001845, LillOA]
17. E. Elisei, J.-F. willart, F. Danede, J. Siepmann, F. Siepmann, M. Descamps, Crystalline Polymorphism Emerging From a Milling-Induced Amorphous Form: The Case of Chlorhexidine Dihydrochloride, Journal of Pharmaceutical Sciences 107, 121-126 (2018), [doi: 10.1016/j.xphs.2017.07.003, LillOA]
16. J.-F. willart, E. Dudognon, A. Mahieu, M.D. Eddleston, W. Jones, M. Descamps, The role of cracks in the crystal nucleation process of amorphous griseofulvin, The European Physical Journal Special Topics 226, 837-847 (2017), [doi: 10.1140/epjst/e2016-60358-y, LillOA]
15. P. Martinetto, P. Bordet, M. Descamps, E. Dudognon, W. Pagnoux, J.-F. willart, Structural Transformations of d -Mannitol Induced by in Situ Milling Using Real Time Powder Synchrotron Radiation Diffraction, Crystal Growth & Design 17, 6111-6122 (2017), [doi: 10.1021/acs.cgd.7b01283, LillOA]
14. A. Benazzouz, E. Dudognon, N. T. Correia, V. Molinier, J.-M. Aubry, M. Descamps, Interactions underpinning the plasticization of a polymer matrix: a dynamic and structural analysis of DMP-plasticized cellulose acetate, Cellulose 24, 487-503 (2017), [doi: 10.1007/s10570-016-1148-y, LillOA]
13. P. Bordet, A. Bytchkov, M. Descamps, E. Dudognon, E. Elkaïm, P. Martinetto, W. Pagnoux, A. Poulain, J.-F. willart, Solid State Amorphization of β-Trehalose: A Structural Investigation Using Synchrotron Powder Diffraction and PDF Analysis, Crystal Growth & Design 16, 4547-4558 (2016), [doi: 10.1021/acs.cgd.6b00660, LillOA]
12. M. Descamps, A. Aumelas, S. Desprez, J.-F. willart, The amorphous state of pharmaceuticals obtained or transformed by milling: Sub-Tg features and rejuvenation, Journal of Non-Crystalline Solids 407, 72-80 (2015), [doi: 10.1016/j.jnoncrysol.2014.08.055, LillOA]
11. E. Gué, S. FLORIN MUSCHERT, J.-F. willart, F. Danede, M. Descamps, E. Delcourt-Debruyne, J. Siepmann, Accelerated fenofibrate release from spray-dried microparticles based on polymer blends, Journal of Drug Delivery Science and Technology 24, 185-190 (2015), [doi: 10.1016/S1773-2247(14)50030-5, LillOA]
10. M. Descamps, E. Dudognon, Crystallization from the Amorphous State: Nucleation-Growth Decoupling, Polymorphism Interplay, and the Role of Interfaces, Journal of Pharmaceutical Sciences 103, 2615-2628 (2014), [doi: 10.1002/jps.24016, LillOA]
9. N. Dujardin, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, Mechanism of Solid State Amorphization of Glucose upon Milling, The Journal of Physical Chemistry B 117, 1437-1443 (2013), [doi: 10.1021/jp3069267, LillOA]
8. E. Dudognon, N. T. Correia, F. Danede, M. Descamps, Solid-Solid Transformation in Racemic Ibuprofen, Pharmaceutical Research 30, 81-89 (2013), [doi: 10.1007/s11095-012-0851-0, LillOA]
7. A. Mahieu, J.-F. willart, E. Dudognon, M.D. Eddleston, W. Jones, F. Danede, M. Descamps, On the polymorphism of griseofulvin: Identification of two additional polymorphs, Journal of Pharmaceutical Sciences 102, 462-468 (2013), [doi: 10.1002/jps.23349, LillOA]
6. A. Mahieu, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, A new protocol to determine the solubility of drugs into polymer matrixes, Molecular Pharmaceutics 10, 560-566 (2013), [doi: 10.1021/mp3002254, LillOA]
5. E. Gué, J.-F. willart, S. MUSCHERT, F. Danede, E. Delcourt, M. Descamps, J. Siepmann, Accelerated ketoprofen release from polymeric matrices: Importance of the homogeneity/heterogeneity of excipient distribution, International journal of pharmaceutics 457, 298-307 (2013), [doi: 10.1016/j.ijpharm.2013.09.023, LillOA]
4. N. Dujardin, E. Dudognon, J.-F. willart, A. Hedoux, Y. Guinet, L. Paccou, M. Descamps, Solid state mutarotation of glucose, J. Phys. Chem. B 115, 1698-1705 (2011), [doi: 10.1021/jp109382j, LillOA]
3. N. Tabary, A. Mahieu, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, m. Bacquet, B. Martel, Characterization of the hidden glass transition of amorphous cyclomaltoheptaose, Carbohydrate research 346, 2193-2199 (2011), [doi: 10.1016/j.carres.2011.07.010, LillOA]
2. P. Derollez, E. Dudognon, F. Affouard, F. Danede, N. T. Correia, M. Descamps, Ab initio structure determination of phase II of racemic ibuprofen by X-ray powder diffraction, Acta Crystallographica Section B 66, 76-80 (2010), [doi: 10.1107/S0108768109047363, LillOA]
1. N. Dujardin, J.-F. willart, E. Dudognon, F. Danede, M. Descamps, First obtaining of glass solutions and phase diagram of glucose with fully tunable anomeric concentration, Journal of Pharmaceutical Sciences 99, 1476 - 1483 (2010), [doi: 10.1002/jps.21900, LillOA]

Full list (The link could be slow)

Conference presentations

10. E. Dudognon, A. Benazzouz, V. Molinier, J.-M. Aubry, M. Descamps, N. T. Correia, Dynamic and structural investigation of interactions at the origin of the plasticization of a polymer matrix: the case of DMP-plasticized Cellulose Acetate, Communication dans un congrès sans actes, 8th International Discussion Meeting on Relaxations in Complex Systems (8IDMRCS), Wisla, Pologne, Jul 2017 [LillOA]
9. A. Krupa, M. Descamps, J.-F. willart, F. Danede, E. Wyska, R. Jachowicz, The technological solutions to enhance the bioavailability of tadalafil, Communication dans un congrès sans actes, The 1st International Conference on Contemporary Pharmacy Challenges, Wisla, Pologne, Sep 2018 [LillOA]
8. M. Descamps, INTRODUCTION TO AMORPHOUS SYSTEMS Glass-forming ability and Stability, Conférence invitée, APV ASD Master Class - Abbvie, Ludwigshafen, Allemagne, Nov 2017 [LillOA]
7. P. Oliveira, J.-F. willart, J. Siepmann, F. Siepmann, M. Descamps, Transformations of dexamethasone drug induced by mechanical milling, Communication dans un congrès sans actes, INCOME 2017 (9th International Conference on Mechanochemistry and Mechanical Alloying), Kosice, Slovaquie, Sep 2017 [LillOA]
6. M. Descamps, The Amorphous State: to get there, to stay there, to identify and use it., Conférence invitée, Pfizer Stability Workshop, Sandwich, Royaume-Uni, Nov 2016 [LillOA]
5. E. Gue, S. MUSCHERT, J.-F. willart, F. Danede, E. Delcourt Debruyne, M. Descamps, J. Siepmann, Accelerated Ketoprofen Release from Spray-Dried Polymeric Particles, Poster, 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbonne, Portugal, Mar 2014 [LillOA]
4. E. Gue, J.-F. willart, S. MUSCHERT, F. Danede, M. Descamps, E. Delcourt Debruyne, J. Siepmann, Eudragit® E-Based Matrices for Accelerated Ketoprofen Release in Acidic Media, Poster, AMPTECH 2014 (Advanced Materials and Pharmaceutical TEChnologies), Villeneuve d'Ascq, France, Jul 2014 [LillOA]
3. E. Gue, S. MUSCHERT, J.-F. willart, F. Danede, E. Delcourt Debruyne, M. Descamps, J. Siepmann, Accelerated Fenofibrate Release from Spray-Dried Microparticles Based on Polymer Blends, Poster, 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbonne, Portugal, Mar 2014 [LillOA]
2. P. Oliveira, J.-F. willart, J. Siepmann, F. Siepmann, M. Descamps, Solid state transformations of dexamethasone induced by milling, Communication dans un congrès sans actes, 2nd European Conference on Pharmaceutics, Kraków, Pologne, Apr 2017 [LillOA]
1. A. Krupa, M. Descamps, J.-F. willart, F. Danede, R. Jachowich, Vitrification of tadalafil by co-milling with soluplus, Communication dans un congrès sans actes, JCAT 46 - Journées de Calorimétrie et d'Analyse Thermique, Montpellier, France, May 2015 [LillOA]

Full list (The link could be slow)