Florence DANEDE

Engineer in material sciences and characterization

Bâtiment P5 - 227
Unité Matériaux et Transformations
Cité scientifique, Bât. P5
Université de Lille
59655 Villeneuve d'Ascq
France
Tel: +33 (0)3 20 43 47 08
Fax: +33 (0)3 20 43 40 84
Email : Send an email to Florence DANEDE
ORCID Identifier : 0000-0001-5139-9187

Research team: Matériaux moléculaires et thérapeutiques

Activity

Powder X-Ray diffraction Thermal analysis (DSC, modulated DSC, TGA) Samples preparation Competent person in radioprotection

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ATG Q500 (TA Instruments)

Research team: Matériaux moléculaires et thérapeutiques.

Contact: Florence DANEDE.

Characterization of solvent losses and degradations in molecular materials
Temperature range: from 30 ° C to 550 ° C

 

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X-ray diffractometer on powders, X'Pert Pro (Panalytical)

Research team: Matériaux moléculaires et thérapeutiques.

Platform: Plateau d’analyses par diffraction des Rayons X.

Contacts: Mathieu GUERAIN, Florence DANEDE.

Study of the structural organization of molecular materials: vitreous states and phase transformations induced by external stresses (temperature variations, grinding, aging, ...)
Technical characteristics

• Copper tube
• Transmission measurements on samples conditioned in capillaries with the possibility of varying the temperature from ambient to 300 ° C (Huber oven)
• Reflection measurements on platelets with the possibility of varying the temperature from -150 ° C to 400 ° C (room Anton Paar TTK 450)

 

Instruments in charge

Latest scientific contributions in LillOA (Lille Open Archive)

Publications

21. T. Rongthong, A. Qnouch, M. Maue Gehrke, L. Paccou, P. Oliveira, F. Danede, J. VERIN, C. Vincent, J.-F. willart, F. Siepmann, J. Siepmann, Silicone matrices for controlled dexamethasone release: toward a better understanding of the underlying mass transport mechanisms., Regenerative Biomaterials 10, rbad008 (2023), [doi: 10.1093/rb/rbad008, LillOA]
20. L.-V. Roca Paixao, N. T. Correia, F. Danede, M.T. Viciosa, A.L. Morritt, Y.Z. Khimyak, F. Affouard, Nature of the Structural and Dynamical Disorder in Organic Cocrystals with a True Nanometric Size Channel-Like Architecture, Crystal Growth & Design 23;1, 120-133 (2023), [doi: 10.1021/acs.cgd.2c00815, LillOA]
19. T. Rongthong, A. Qnouch, M.M. Gehrke, F. Danede, J.-F. willart, P.F.M. De Oliveira, L. Paccou, G. Tourrel, P. Stahl, J. VERIN, P. Toulemonde, C. Vincent, F. Siepmann, J. Siepmann, Long term behavior of dexamethasone-loaded cochlear implants: In vitro & in vivo, International Journal of Pharmaceutics: X 4, 100141 (2022), [doi: 10.1016/j.ijpx.2022.100141, LillOA]
18. Y. Guinet, L. Paccou, F. Danede, P. Derollez, A. Hedoux, Identification of incommensurability in L-leucine: can lattice instabilities be considered as general phenomena in hydrophobic amino acids?, Physical Chemistry Chemical Physics 24, 27023-27030 (2022), [doi: 10.1039/d2cp00989g, LillOA]
17. C. Bassand, L. Benabed, J. Verin, F. Danede, L. Lefol, J.-F. willart, F. Siepmann, J. Siepmann, Hot melt extruded PLGA implants loaded with ibuprofen: How heat exposure alters the physical drug state, JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 73, 103432 (2022), [doi: 10.1016/j.jddst.2022.103432, LillOA]
16. C. Bassand, L. Benabed, J. Verin, F. Danede, L. Lefol, J.-F. willart, F. Siepmann, J. Siepmann, Hot melt extruded PLGA implants loaded with ibuprofen: How heat exposure alters the physical drug state, JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 73, 103432 (2022), [doi: 10.1016/j.jddst.2022.103432, LillOA]
15. C. Bassand, L. Benabed, J. Verin, F. Danede, L. Lefol, J.-F. willart, F. Siepmann, J. Siepmann, L. Benabed, Hot melt extruded PLGA implants loaded with ibuprofen: How heat exposure alters the physical drug state, Journal of Drug Delivery Science and Technology 73, 103432 (2022), [doi: 10.1016/j.jddst.2022.103432, LillOA]
14. J.-F. willart, S. Ouerghemmi, N. Descamps, P. Heijboer, L. Paccou, F. Danede, M. Descamps, The melting of glucose, International Journal of Pharmaceutics 626, 122185 (2022), [doi: 10.1016/j.ijpharm.2022.122185, LillOA]
13. A. Krupa, F. Danede, A. Węgrzyn, D. Majda, J.-F. willart, Thinking of bosentan repurposing – A study on dehydration and amorphization, International Journal of Pharmaceutics 622, 121846 (2022), [doi: 10.1016/j.ijpharm.2022.121846, LillOA]
12. A. Dupont, M. Guerain, F. Danede, J.-F. willart, Evidence of transient amorphization during the polymorphic transformation of sorbitol induced by milling, International Journal of Pharmaceutics 121929 (2022), [doi: 10.1016/j.ijpharm.2022.121929, LillOA]
11. Y. Guinet, L. Paccou, F. Danede, A. Hedoux, Revisiting the phase transition sequence in L-methionine: Description of the disordering mechanism in an essential amino acid, Journal of Chemical Physics 156;3, 034501 (2022), [doi: 10.1063/5.0077743, LillOA]
10. E. Dudognon, F. Danede, M. Guerain, Milling-induced Phase Transformations, Underlying Mechanisms and Resulting Physical States in an Enantiotropic System: the Case of Bezafibrate, Crystal Growth & Design 22;1, 363-378 (2022), [doi: 10.1021/acs.cgd.1c00997, LillOA]
9. Y. Benzine, F. Siepmann, C. Neut, F. Danede, J.-F. willart, J. Siepmann, y. karrout, Injection-molded capsule bodies and caps based on polymer blends for controlled drug delivery, European Journal of Pharmaceutics and Biopharmaceutics 168, 1-14 (2021), [doi: 10.1016/j.ejpb.2021.08.007, LillOA]
8. Y. Guinet, L. Paccou, F. Danede, A. Hedoux, Confinement of molecular materials using a solid-state loading method: a route for exploring new physical states and their subsequent transformation highlighted by caffeine confined to SBA-15 pores, RSC Advances 11;55, 34564-34571 (2021), [doi: 10.1039/D1RA05757J, LillOA]
7. M. Guerain, F. Affouard, C. Henaff, C. Dejoie, F. Danede, J. Siepmann, F. Siepmann, J.-F. willart, Structure determination of riboflavin by synchrotron high-resolution powder X-ray diffraction, Acta Crystallographica Section C Structural Chemistry 77;12, 800-806 (2021), [doi: 10.1107/s2053229621012171, LillOA]
6. A. Qnouch, V. Solarczyk, J. Verin, G. Tourrel, P. Stahl, F. Danede, J.-F. willart, P.-E. Lemesre, C. Vincent, J. Siepmann, F. Siepmann, Dexamethasone-loaded cochlear implants: How to provide a desired “burst release”, International Journal of Pharmaceutics: X 100088 (2021), [doi: 10.1016/j.ijpx.2021.100088, LillOA]
5. M. Guerain, Y. Guinet, N. T. Correia, L. Paccou, F. Danede, A. Hedoux, Polymorphism and stability of ibuprofen/nicotinamide cocrystal: The effect of the crystalline synthesis method, International Journal of Pharmaceutics 584, 119454 (2020), [doi: 10.1016/j.ijpharm.2020.119454, LillOA]
4. O. Cantin, F. Siepmann, J.-F. willart, F. Danede, J. Siepmann, y. karrout, PEO hot melt extrudates for controlled drug delivery: Importance of the type of drug and loading, Journal of Drug Delivery Science and Technology 102238 (2020), [doi: 10.1016/j.jddst.2020.102238, LillOA]
3. S. Inocencio, T. Cordeiro, I. Matos, F. Danede, J.C. Sotomayor, I.M. Fonseca, N. T. Correia, M.C. Corvo, M. Dionísio, Ibuprofen incorporated into unmodified and modified mesoporous silica: From matrix synthesis to drug release, Microporous and Mesoporous Materials 310, 110541 (15 p.) (2020), [doi: 10.1016/j.micromeso.2020.110541, LillOA]
2. M. Latreche, J.-F. willart, L. Paccou, Y. Guinet, F. Danede, A. Hedoux, Contribution of low-frequency Raman spectroscopy to determine the solubility curves of drugs in polymers: The case of paracetamol/PVP, European Journal of Pharmaceutics and Biopharmaceutics 154, 222-227 (2020), [doi: 10.1016/j.ejpb.2020.07.012, LillOA]
1. A. Dupont, M. Guerain, F. Danede, L. Paccou, Y. Guinet, A. Hedoux, J.-F. willart, Kinetics and mechanism of polymorphic transformation of sorbitol under mechanical milling, International Journal of Pharmaceutics 590, 119902 (2020), [doi: 10.1016/j.ijpharm.2020.119902, LillOA]

Full list (The link could be slow)

Conference presentations

10. L.-V. Roca Paixao, F. Danede, N. T. Correia, F. Affouard, WHEN RESIDUAL WATER INFLUENCES THE COCRYSTALLIZATION OUTPUT: THE CARBAMAZEPINE AND TARTARIC ACID CASE, Communication dans un congrès sans actes, Journées SolvATE 2021, Lille, France, Dec 2021 [LillOA]
9. N. T. Correia, T. Cordeiro, F. Affouard, I. Matos, F. Danede, J. Sotomayor, M. Corvo, I. Fonseca, M. Dionísio, M.T. Viciosa, Simvastatine confinée dans MCM-41 : désordre dynamique, organisations/interactions moléculaires et leurs implications sur la vitesse de dissolution et le profil de libération, Poster, Conference Internationale "Matériaux 2022", Lille, France, Oct 2022 [LillOA]
8. N. T. Correia, L.-V. Roca Paixao, F. Danede, M.T. Viciosa, A.L. Morritt, Y.Z. Khimyak, F. Affouard, Dynamic Disorder in a Nano-Sized Channel-Shaped Pharmaceutical Cocrystal Architecture, Conférence invitée, 11th Conference on Broadband Dielectric Spectroscopy and its applications, San Sebastian, Espagne, Sep 2022 [LillOA]
7. L.-V. Roca Paixao, F. Danede, M. Guerain, N. T. Correia, F. Affouard, Affinity Prediction And Synthesis Of Carbamazepine-based Cocrystals, Poster, 17th European Conference on Solid State Chemistry (ECSSC17), Villeneuve d'Ascq, France, Sep 2019 [LillOA]
6. M. Guerain, P. Derollez, C. Dejoie, N. T. Correia, F. Danede, F. Affouard, L. Paccou, Y. Guinet, A. Hedoux, C. Dejoie, Analyse structurale de matériaux moléculaires thérapeutiques cocristallisés par diffraction des rayons X, Communication dans un congrès sans actes, Rayons X et Matière 2019, Nancy, France, Nov 2019 [LillOA]
5. F. Tamani, C. Bassand, M.H.-B. Yelles, J.-F. willart, F. Danede, F. Siepmann, J. Siepmann, How single PLGA microparticles behave, Poster, 3rd European Conference on Pharmaceutics, Bologne, Italie, Mar 2018 [LillOA]
4. T. Rongthong, M. Gehrke, P. Oliveira, F. Danede, J.-F. willart, C. Vincent, F. Siepmann, J. Siepmann, Silicone matrices for controlled drug delivery to the inner ear: Effects of the drug form and agglomerates, Poster, 11th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical technology, Granada, Espagne, Mar 2018 [LillOA]
3. A. Krupa, M. Descamps, J.-F. willart, F. Danede, E. Wyska, R. Jachowicz, The technological solutions to enhance the bioavailability of tadalafil, Communication dans un congrès sans actes, The 1st International Conference on Contemporary Pharmacy Challenges, Wisla, Pologne, Sep 2018 [LillOA]
2. M. Dionísio, T. Cordeiro, S. Inocêncio, M.C. Corvo, I. Matos, J. Sotomayor, I. Fonseca, M.M. Cardoso, M.T. Viciosa, F. Danede, F. Affouard, N. T. Correia, Stabilizing high internal energetic states of pharmaceutical drugs by nanoconfinement, Communication dans un congrès sans actes, 0th Conference on BROADBAND DIELECTRIC SPECTROSCOPY AND ITS APPLICATIONS, Brussels, Belgique, Aug 2018 [LillOA]
1. L.-V. Roca Paixao, F. Danede, M. Guerain, N. T. Correia, F. Affouard, Coformers predictions, synthesis and characterization of pharmaceutical cocrystals, Communication dans un congrès sans actes, 13th International Workshop of the Crystal Growth of Organic Material (CGOM13), Seoul, Corée du Sud, Aug 2018 [LillOA]

Full list (The link could be slow)